25,729 articles
PPoma
PPoma, or pancreatic polypeptidoma, is a rare non-functioning pancreatic endocrine tumor hypersecreting pancreatic polypeptide; it causes only non-specific symptoms, is diagnosed late, often metastasizes to the liver, and can occur with MEN-1.
PPV-CVP-FLUID study
PPV-CVP-FLUID is a randomized trial comparing pulse pressure variation versus central venous pressure guidance for intraoperative fluid management in intracranial tumor surgery; 60 patients, PPV group had better hemodynamic stability and less postoperative fluid.
Prabhakara rasa
Prabhakara rasa (Prabhākara rasa), a classical Ayurvedic herbo-mineral formulation (AFI000357) of purified mercury, sulphur, five animal biles, and Plumbago zeylanica and Aconitum ferox roots, dosed 125 mg; distinct from Prabhakara Vati.
Prabhakara vati
Prabhakara vati (प्रभाकर वटी) is a classical Ayurvedic herbo-mineral pill combining calcined mica, iron, chalcopyrite, shilajatu, and bamboo manna with arjuna bark decoction, prescribed mainly for heart disease.
Prabhanjana vimardana taila
Prabhanjana Vimardana Taila (Prabhanjana Vimardana Thailam) is a classical Ayurvedic medicated sesame oil from Sahasrayoga, cooked with milk, curd, kanjika, and about 31 herbs, used mainly externally for vata disorders such as facial palsy, hernia, backache, and knee osteoarthritis.
Pracinostat
Pracinostat (SB939), an oral pan-HDAC inhibitor cancer drug candidate with FDA orphan drug status for AML; phase 3 PRIMULA showed no survival benefit over azacitidine alone.
Practical Nursing
Practical nursing (LPN/LVN) is licensed, non-registered nursing practice providing routine bedside care under RN or physician supervision. Entry requires a 12-18 month program, the NCLEX-PN, and state-defined scope; US median pay was $64,400 in May 2025.
Practice Management
Practice management: the business administration of medical, dental, and veterinary practices, covering billing, staffing, compliance, and payer contracting; also the software category and the MGMA-credentialed profession supporting independent clinical practices.
Pradarantaka Lauha
Pradarantaka Lauha (Pradarantak Lauh), an Ayurvedic herbo-mineral iron formulation from Bhaishajya Ratnavali for menorrhagia, leucorrhea, and anemia; AFI-listed, 250 mg dose, least effective of six iron preparations in one trial.
Pradarantaka Rasa
Pradarantaka Rasa (Pradarāntaka rasa), an Ayurvedic herbo-mineral formulation with mercury, zinc ore, tin, silver, cowrie shell, sulphur, aloe, and iron; AFI dose 125 mg, used for pradara (menstrual bleeding disorders).
Pradarari lauha
Pradarari lauha (Pradarāri lauha), a classical Ayurvedic Lauha Kalpa from Bhaishajya Ratnavali 66/74-78 and AFI000151, combines calcined iron, calcined mica, and astringent herbs; dosed 1-2 g for pradara (abnormal vaginal discharge).
Pradefovir
Pradefovir (pradefovir mesylate, MB-06866, remofovir) is a HepDirect liver-targeted prodrug of adefovir for chronic hepatitis B, activated by hepatic CYP3A4; approved in China in 2024, noninferior to tenofovir disoproxil fumarate in phase 2/3 trials.
Prademagene zamikeracel
Prademagene zamikeracel (Zevaskyn, formerly EB-101) is an autologous COL7A1 gene-modified keratinocyte sheet gene therapy for recessive dystrophic epidermolysis bullosa wounds, FDA-approved April 28, 2025 after the VIITAL phase 3 trial.
Pradigastat
Pradigastat (LCQ-908, ANJ908) is Novartis's oral DGAT1 inhibitor that cut fasting triglycerides up to 70% in familial chylomicronemia but was abandoned in 2017 over gastrointestinal side effects; later repurposed for constipation.
Pragmatic clinical trial
A pragmatic clinical trial is a randomized trial testing whether an intervention works in routine care settings with broad eligibility, measuring real-world effectiveness rather than efficacy under ideal conditions.
PRAGUE-17 trial
PRAGUE-17 (NCT02426944), a Czech randomized noninferiority trial, was the first to compare left atrial appendage closure (Amulet, Watchman) with DOACs, mostly apixaban, in 402 high-risk atrial fibrillation patients, meeting noninferiority for its composite endpoint.
Prajmalium
Prajmalium (prajmaline, N-propylajmaline) is a class IA antiarrhythmic, ATC C01BA08, derived from the ajmaline rauwolfia alkaloid; used as bitartrate in German-speaking countries for ventricular arrhythmias, half-life 7.3 h, may cause liver damage.
Pralatrexate
Pralatrexate (Folotyn, PDX) is a folate analog DHFR inhibitor, first FDA-approved drug (2009, accelerated) for relapsed/refractory peripheral T-cell lymphoma; 30 mg/m2 weekly with B12/folic acid; FDA-approved but not EMA-approved.
Pralidoxime
Pralidoxime (2-PAM, contrathione, protopam), a pyridinium aldoxime discovered in 1955, reactivates organophosphate-inhibited acetylcholinesterase; the only FDA-approved oxime for OP poisoning, given with atropine, though trial evidence of benefit is contested.
Pralsetinib
Pralsetinib (Gavreto, BLU-667) is an oral selective RET kinase inhibitor approved by the FDA in September 2020 for RET fusion-positive NSCLC; EU authorization was withdrawn in 2024.
PRAM-in-HYPO study
PRAM-in-HYPO (NCT05960604) is a recruiting Turkish observational trial of 660 hypertensive surgical patients testing Pressure Recording Analytical Method (MostCare) hemodynamic parameters, including cardiac reserve and efficiency, against hypotension using passive leg raising.
Pramehamihira Taila
Pramehamihira Taila (Prameha mihira taila) is a classical Ayurvedic medicated sesame-oil formulation from Bhaishajya Ratnavali, AFI 8:31, with over 40 ingredients, dosed 6-12 g orally or as abhyanga, for prameha and urinary disorders.
Pramipexole
Pramipexole (Mirapex, Mirapexin, Sifrol) is a non-ergot dopamine agonist, D3-preferring, FDA-approved in 1997 for Parkinson disease and 2006 for restless legs syndrome; dosed up to 4.5 mg/day ER, with sleep attacks, impulse control disorders, and augmentation as key risks.
Pramoxine
Pramoxine (pramocaine), a morpholine-ether topical anesthetic and antipruritic sold as pramoxine hydrochloride, blocks sodium channels to relieve itching and pain from hemorrhoids, insect bites, and minor skin irritation.
Pranada Gutika
Pranada Gutika (प्राणदागुटिका), also spelled Pranda Gutika, is a classical Ayurvedic jaggery-bound herbal tablet from Bhaishajya Ratnavali, indicated mainly for Arsha (hemorrhoids) and studied in CCRAS clinical trials.
Pranlukast
Pranlukast (Onon, ONO-1078, SB 205312) is an oral leukotriene receptor antagonist blocking CysLT1; the first LTRA marketed (Japan, 1995), used mainly in Japan for asthma and allergic rhinitis, dose 225 mg twice daily.
Prasarni Taila
Prasarni Taila (प्रसारिणी तैलम्, Prasarini Taila/Thailam) is a classical Ayurvedic medicated sesame-oil preparation built on Paederia foetida, used for Vata disorders such as sciatica, stiffness, and facial palsy, standardized in the Ayurvedic Formulary of India.
Prasterone
Prasterone (dehydroepiandrosterone, DHEA) is an endogenous steroid given as a 6.5 mg once-daily vaginal insert (Intrarosa) for moderate to severe dyspareunia from menopausal vulvovaginal atrophy; FDA approved 2016, distinct from oral DHEA products.
Prasugrel
Prasugrel, sold as Effient and Efient, is an oral antiplatelet drug used with aspirin to prevent blood clots in acute coronary syndrome patients undergoing stent procedures.
Pratapalankesvara Rasa
Pratapalamkesvara Rasa (Pratāpalaṅkeśvara Rasa, प्रतापलङ्केश्वररस) is a herbo-mineral Ayurvedic Rasashastra formulation, mainly for postpartum (sutika/prasuta vata) disorders, with about 20 classical variants including Yoga Ratnakara's mercury, mica, iron, conch, and aconite recipe, dosed 125–375 mg.