Human health and medicine

RESTORE trial (NCT06300268)

RESTORE trial (NCT06300268): prospective multicentre pilot study of the AdvaPro sirolimus-eluting coronary stent in Indian and European populations; 120 patients, not yet recruiting, MACE at 9 months.

Restriction spectrum imaging

Restriction spectrum imaging (RSI) is a magnetic resonance imaging technique that separates restricted, hindered, and free water diffusion, quantifying tissue microstructure for brain tumor and prostate cancer diagnosis.

Restrictive cardiomyopathy

Restrictive cardiomyopathy is a rare heart muscle disease, about 5% of cardiomyopathies, in which stiff ventricles resist filling, raising filling pressures and enlarging the atria; causes include amyloidosis.

Restrictive dermopathy

Restrictive dermopathy, also called lethal tight skin contracture syndrome, is a rare genetic disease in which very tight skin restricts fetal movement, usually killing newborns within days.

Restrictive lung disease

Restrictive lung disease: disorders with reduced total lung capacity from stiff lungs, chest wall, pleural, or neuromuscular causes; normal or high FEV1/FVC ratio; includes pulmonary fibrosis, sarcoidosis, scoliosis.

Restrictive ophthalmopathy

Restrictive ophthalmopathy (拘束性眼症), ICD-11 9C82.3, is mechanical restriction of eye movement from stiff or fibrotic extraocular muscles, chiefly in thyroid eye disease (Graves' ophthalmopathy), causing diplopia and limited elevation.

Resurfacing arthroplasty

Resurfacing arthroplasty is a hip operation in which only the damaged joint surfaces are replaced, preserving the femoral neck; it suits younger patients with arthritis.

Resuscitative endovascular balloon occlusion of the aorta

REBOA (resuscitative endovascular balloon occlusion of the aorta) is a temporary hemorrhage-control procedure using a balloon catheter inflated in aortic Zone 1 or 3 for non-compressible torso hemorrhage; first used by Hughes in 1954, limited by ischemia time, with conflicting trial evidence including UK-REBOA.

Resuscitative thoracotomy

Resuscitative thoracotomy is an emergency surgical procedure that opens the chest in traumatic cardiac arrest or profound shock, relieving tamponade, repairing cardiac wounds, clamping the aorta, and salvaging mainly penetrating trauma.

RET rearrangement analysis

RET rearrangement analysis is a molecular diagnostic test that detects RET gene fusions in tumors, most often papillary thyroid carcinoma and non-small-cell lung cancer, guiding treatment with selective RET inhibitors.

Retagliptin and metformin tablets

Retagliptin and metformin tablets (瑞格列汀二甲双胍片, Ruilintang) is a Hengrui Category 1 fixed-dose combination of the DPP-4 inhibitor retagliptin 50 mg and metformin 850 mg, approved in China in May 2025 for type 2 diabetes adults.

Retagliptin phosphate

Retagliptin phosphate (瑞泽唐) is a DPP-4 inhibitor by Jiangsu Hengrui, approved by China's NMPA in June 2023 as a Category 1 drug for adult type 2 diabetes; China's first domestically developed gliptin.

Retagliptin, henagliflozin, and metformin tablets

Henagliflozin/retagliptin/metformin extended-release tablets (恒格列净瑞格列汀二甲双胍缓释片), a Hengrui once-daily triple fixed-dose combination for type 2 diabetes, NMPA-approved 21 October 2025; phase 3 showed HbA1c reductions of 1.51–1.54% at 24 weeks.

Retained dental root

Retained dental root (dental root retention), ICD-11 DA0A.3 and ICD-10 K08.3: a root or root fragment left in the jaw after extraction fracture, caries, or trauma; found in about 13% of Finnish adults, most often in the third molar region.

Retained medullary cord

Retained medullary cord (RMC, ORPHA:645334) is a rare closed spinal dysraphism in which a non-functional vestigial cord persists below the conus from failed secondary neurulation regression; MRI cannot distinguish it, so intraoperative neurophysiological monitoring is mandatory.

Retapamulin

Retapamulin, sold as Altabax and Altargo, is a topical pleuromutilin antibiotic developed by GlaxoSmithKline for superficial skin infections like impetigo, the first of its class approved for humans in 2007.

Retaspimycin

Retaspimycin (IPI-504) is a water-soluble hydroquinone hydrochloride salt of 17-AAG, an HSP90 inhibitor developed by Infinity Pharmaceuticals for cancer; it reached phase III GIST and phase II NSCLC trials before development was discontinued in 2013.

Retavibart (TNM001)

Retavibart (TNM001, 芮特韦拜单抗, brand Xinduotuo) is Trinomab's long-acting fully human anti-RSV monoclonal antibody targeting the pre-F protein; NMPA approved it in September 2026 for preventing RSV lower respiratory tract infection in infants entering their first RSV season.

Retention in Care

Retention in care (HIV): continued routine engagement in HIV medical care after linkage, a key care-continuum step. Measured by missed-visit, kept-visit, and WHO ART.5 cohort indicators; US 2024 retention 56%.

Reteplase

Reteplase (r-PA, Rapilysin) is a nonglycosylated recombinant tPA deletion mutant thrombolytic with kringle-2 and protease domains, given as two 10-unit boluses 30 minutes apart; FDA-approved 1996 for myocardial infarction, EU authorization withdrawn 2024.

Rethink Food

Rethink Food: chiefly Rethink Food NYC, Inc., a 501(c)(3) founded 2017 by Matt Jozwiak that pays minority- and women-owned restaurants to prepare rescued meals; also a UK school food nonprofit running the National School Pantry Network.

Reticular dysgenesis

Reticular dysgenesis, also called AK2 deficiency or De Vaal disease, is the most severe form of severe combined immunodeficiency: autosomal recessive AK2 mutations cause agranulocytosis, T and NK lymphocytopenia, and sensorineural deafness, fatal without stem cell transplantation.

Reticular dystrophy of the retinal pigment epithelium

Reticular dystrophy of the retinal pigment epithelium (dystrophia reticularis laminae pigmentosae retinae, Sjögren 1950) is a rare inherited pattern macular dystrophy with a bilateral fishnet RPE pigment pattern, adult onset, good visual prognosis, PRPH2 linkage.

Reticular erythematous mucinosis

Reticular erythematous mucinosis (REM syndrome, midline mucinosis) is a rare chronic skin mucinosis causing reticulated red papules and plaques on the midline chest and upper back of middle-aged women, treated with antimalarials.

Reticular formation

Reticular formation (formatio reticularis): brainstem neuron network from midbrain to medulla regulating arousal, consciousness, sleep-wake cycles, and autonomic functions; source of the ascending reticular activating system (RAS) identified by Moruzzi and Magoun in 1949.

Reticular pseudodrusen

Reticular pseudodrusen, or subretinal drusenoid deposits, are yellowish subretinal lesions above the retinal pigment epithelium in age-related macular degeneration, strongly predicting progression to geographic atrophy and detectable only with multimodal imaging.

Reticulate acropigmentation of Kitamura

Reticulate acropigmentation of Kitamura (RAK, RAPK) is a rare autosomal dominant skin hyperpigmentation disorder caused by ADAM10 loss-of-function mutations, producing reticulate, depressed brown macules on the hands and feet without hypopigmentation.