25,729 articles
Silent treatment
Silent treatment: deliberate withholding of communication to punish, control, or avoid conflict; a dyadic form of ostracism studied by Kipling Williams, linked to pain, stonewalling, and relationship dissolution.
Silica–gold nanoshell therapy
Silica–gold nanoshell therapy, known as AuroLase therapy using AuroShell particles, is an investigational cancer treatment in which infused gold-coated silica nanoparticles destroy tumor cells when heated by near-infrared laser light.
SILICOFCM trial
SILICOFCM (NCT03832660) was a phase II randomized open-label trial of sacubitril/valsartan versus lifestyle intervention in nonobstructive hypertrophic cardiomyopathy; 115 patients randomized, 16-week treatment did not improve peak VO2, structure, or function.
Silicosis
Silicosis, also called silica-induced pneumoconiosis, is an incurable progressive occupational lung fibrosis caused by inhaling respirable crystalline silica dust from mining, construction, and engineered stone work; named by Visconti in 1870, with no cure and rising engineered-stone outbreaks.
Silodosin
Silodosin (Urief, Rapaflo, Silodyx) is a selective alpha-1A adrenergic receptor antagonist approved for BPH/LUTS, launched in Japan 2006 and FDA-approved 2008; main side effect is abnormal ejaculation, and it outperforms tamsulosin for ureteral stone expulsion.
Siltartoxatug
Siltartoxatug (TNM002, Sintetol, 新替妥) is the first recombinant human IgG1 monoclonal antibody against tetanus toxin, approved in China in February 2025 for emergency tetanus prophylaxis in adults, outperforming HTIG in phase 3 trials.
Siltuximab
Siltuximab (SYLVANT, CNTO 328) is a chimeric anti-IL-6 monoclonal antibody approved in 2014 for HIV-negative, HHV-8-negative multicentric Castleman disease, dosed 11 mg/kg IV every 3 weeks.
Silver sulfadiazine
Silver sulfadiazine (SSD), also called Flammazine, is a 1% topical cream combining silver and the sulfonamide sulfadiazine, introduced by Charles Fox Jr. in 1968 for preventing and treating infection in burn wounds.
Silver-Russell syndrome
Silver-Russell syndrome, also called Russell-Silver syndrome, is a genomic imprinting disorder causing restricted growth before and after birth, with macrocephaly, body asymmetry, and feeding problems.
SILVHIA trial
SILVHIA (Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol), NCT00389168: Swedish double-blind trial in 115 hypertensive patients with LVH; irbesartan reduced left ventricular mass more than atenolol (-26 vs -14 g/m2) despite equal blood pressure control.
SIM0278 (IL-2 mutein Fc fusion)
SIM0278 (ALM223) is Simcere's Treg-preferential IL-2 mutein Fc fusion protein for autoimmune disease, licensed to Almirall outside Greater China, now in Phase II trials for atopic dermatitis, alopecia areata, and lupus.
SIM0500, GPRC5D/BCMA/CD3 trispecific antibody
SIM0500 is a humanized GPRC5D-BCMA-CD3 trispecific T-cell engager antibody by Simcere Zaiming for relapsed/refractory multiple myeloma, in Phase 1 trials (NCT06375044) in China and the U.S., with an AbbVie option-to-license deal worth up to $1.055 billion.
SIM0660
SIM0660 is a preclinical CD79a/CD19/CD3 tri-specific T-cell engager from Simcere Zaiming (2096.HK), licensed globally to Roche on 1 September 2026 for $75 million upfront and up to $1.53 billion total, targeting B-cell-mediated diseases.
SIM0709
SIM0709 is a preclinical, half-life-extended TL1A/IL-23p19 bispecific antibody from Simcere (先聲藥業) for inflammatory bowel disease; Boehringer Ingelheim licensed global rights outside Greater China in January 2026 for up to €1.058 billion.
Simcere CDH6 antibody-drug conjugate
SIM0505 (SCR-9359), Simcere Zaiming's CDH6-targeting antibody-drug conjugate with CPT116 topoisomerase 1 inhibitor payload; Phase 1 (NCT06792552) in advanced solid tumors, licensed ex-Greater China to NextCure for up to $745M, FDA Fast Track for platinum-resistant ovarian cancer.
Simeprevir
Simeprevir (TMC435, Olysio) is a second-wave macrocyclic HCV NS3/4A protease inhibitor approved by the FDA in November 2013 for genotype 1 chronic hepatitis C with peginterferon/ribavirin, limited by the Q80K polymorphism; EU marketing withdrawn in 2018.
Simeticone
Simeticone (simethicone), a polydimethylsiloxane plus silica antifoaming agent, relieves gas-related bloating and improves colonoscopy bowel preparation; not absorbed, ineffective for infant colic, and a reprocessing biofilm concern.
Simhanada Guggulu
Simhanada Guggulu, a classical Ayurvedic pill of guggulu resin, Triphala, purified sulphur, and castor oil, first in Chakradatta, pharmacopoeial, used mainly for Amavata (rheumatoid arthritis), dose up to 3 g daily.
Simnotrelvir/ritonavir
Simnotrelvir/ritonavir (Xiannuoxin, 先诺欣) is Simcere's oral 3CL protease inhibitor combination for mild-to-moderate COVID-19 in adults, conditionally approved in China January 2023, regular approval July 2024, shortening symptom resolution by about 36 hours.
Simoctocog alfa
Simoctocog alfa (Nuwiq, Vihuma) is a fourth-generation B-domain-deleted recombinant human coagulation factor VIII made in HEK 293F cells, approved in 2014 for treating and preventing bleeding in haemophilia A.
Simone Sandier
Simone Sandier is a French health economist who spent her career at CREDES, studying physician payment, health spending, and rationing under French national health insurance.
Simple chronic bronchitis
Simple chronic bronchitis (ICD-11 CA20.10, ICD-10 J41.0) is chronic mucus hypersecretion with productive cough but no airflow obstruction; also called chronic catarrhal or smokers bronchitis.
Simple columnar epithelium
Simple columnar epithelium (Epithelium simplex columnare) is a single layer of tall cells with basal oval nuclei, ciliated in the female genital tract and nonciliated with microvilli in the gastrointestinal and biliary tracts, serving secretion and absorption.
Simple cryoglobulinemia
Simple cryoglobulinemia, also called type I or monoclonal cryoglobulinemia, is a serum disorder in which one monoclonal immunoglobulin (usually IgG or IgM) precipitates below 37°C, almost always linked to B-cell disorders like myeloma or Waldenström macroglobulinemia.
Simple febrile seizures
Simple febrile seizures are brief (<15 min), generalized, non-recurrent seizures with fever in children 6-60 months, also called typical febrile convulsions. They affect 2-5% of children, need no EEG or imaging, and carry an excellent prognosis with about one-third recurrence risk.
Simple interrupted stitch
The simple interrupted stitch is a basic surgical suturing technique in which each stitch is a single loop tied off individually, so one failed stitch leaves the others intact.
Simple living
Simple living (voluntary simplicity): a voluntarily chosen, less consumption-focused lifestyle coined as a term by Richard Gregg in 1936 and popularized by Duane Elgin; linked to modestly higher well-being (g = .28) and a 23% smaller ecological footprint.
Simple renal cyst
Simple renal cyst (simple kidney cyst): benign, thin-walled, fluid-filled sac in the kidney, found in about 1 in 10 people and nearly 1 in 5 over age 50, more common in men; usually symptomless, treated only if symptomatic with sclerotherapy or laparoscopic surgery.
Simplified Acute Physiology Score
The Simplified Acute Physiology Score (SAPS) is an ICU severity scoring system; its standard version, SAPS II, uses 17 variables from the first 24 hours to predict hospital death.
Simpson-Golabi-Behmel syndrome
Simpson-Golabi-Behmel syndrome is a rare X-linked congenital disorder, seen mainly in males, causing overgrowth before and after birth, distinctive facial features, birth defects, and a raised tumor risk.