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Steven Yeh
Steven Yeh is an American ophthalmologist specializing in uveitis and vitreoretinal surgery, professor and chair of ophthalmology at the University of Nebraska Medical Center and director of the retina and uveitis service at Nebraska Medicine.
Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum
Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum (SJS-TEN, epidermal necrolysis): a rare, mainly drug-induced mucocutaneous reaction with skin and mucosal detachment, subforms SJS (<10% BSA), overlap (10-29%), TEN (≥30%), mortality 20-25% in extensive forms.
Stevens–Johnson syndrome
Stevens–Johnson syndrome (SJS), with toxic epidermal necrolysis (Lyell syndrome) at the severe end, is a rare drug-triggered blistering skin-mucosa reaction; mortality about 10% in SJS, up to 50% in TEN; SCORTEN predicts death.
Stewart–Treves syndrome
Stewart–Treves syndrome is angiosarcoma arising in chronically lymphedematous tissue, classically the arm after mastectomy; first described 1948, it appears about 15 years after lymphedema with poor survival.
Stibogluconic acid
Stibogluconic acid is the gluconic acid complex of pentavalent antimony underlying sodium stibogluconate (SSG, Pentostam), the 1945 antileishmanial injection drug; its structure remains oligomeric and incompletely defined.
STICH trial
STICH (Surgical Treatment for Ischemic Heart Failure), NHLBI-sponsored randomized trial of 2,112 patients testing CABG plus medical therapy versus medical therapy alone in ischemic left ventricular dysfunction; null at 5 years, survival benefit at 10 years (STICHES).
Stickler syndrome
Stickler syndrome (hereditary progressive arthro-ophthalmopathy), a collagen connective tissue disorder causing high myopia, retinal detachment, cleft palate, hearing loss, and early arthritis; mostly autosomal dominant COL2A1.
Stiff skin syndrome
Stiff skin syndrome (SSS), also called congenital fascial dystrophy, is a rare autosomal dominant FBN1-related fibrosing skin disorder with rock-hard skin, joint contractures, and hypertrichosis from infancy, distinct from stiff-person syndrome.
Stiff-person syndrome
Stiff-person syndrome (SPS), also called stiff-man syndrome or stiff person spectrum disorder (SPSD), is a rare autoimmune neurological disorder causing trunk and limb rigidity, stimulus-triggered spasms, and falls, linked to GAD65 antibodies and often misdiagnosed.
Stiffness of joint
Joint stiffness (stiff joints) is the sensation of limited or difficult joint motion after inactivity, a major symptom of arthritis. Inflammatory causes produce prolonged morning stiffness over 30-60 minutes; mechanical causes such as osteoarthritis produce brief stiffness under 30 minutes.
Stillbirth
Stillbirth, also called fetal demise, is the death of a baby before or during birth, at or beyond 22 weeks of pregnancy according to the World Health Organization.
Stimulant
Stimulants, also known as psychostimulants, are drugs that boost brain chemicals to increase alertness, attention, and energy, ranging from caffeine to prescription drugs that treat ADHD and narcolepsy.
Stimulant psychosis
Stimulant psychosis: drug-induced delusions and hallucinations from amphetamine, methamphetamine, cocaine, or prescription stimulants; affects 36.5% of methamphetamine users versus 0.2% of therapeutic users; usually transient, 19–33% transition to primary psychosis.
Stimulated Raman scattering histology
Stimulated Raman scattering histology (SRH) is a label-free optical imaging method producing histology-like images of unprocessed surgical tissue, developed for brain tumor diagnosis in the operating room.
Stimuli-responsive nanoparticles
Stimuli-responsive nanoparticles are drug-delivery particles that release cargo in response to triggers like pH, redox state, enzymes, light, ultrasound, or heat, aiming to boost efficacy and cut toxicity.
Stimulus (physiology)
Stimulus (physiology): a detectable environmental or internal change (light, sound, chemical, temperature, pressure) that activates sensory receptors. Key facts: transduction into graded receptor potentials, coding of modality, location, intensity, duration, and receptor adaptation.
Stimulus control
Stimulus control is a behavioral technique in which environmental cues are arranged so a desired behavior occurs reliably, central to behavior therapy, applied behavior analysis, and insomnia treatment.
STING-associated vasculopathy with onset in infancy
STING-associated vasculopathy with onset in infancy (SAVI) is a rare genetic autoinflammatory disease, first described in 2014, causing severe skin lesions and progressive lung disease in infants.
Stinging of skin
Stinging of skin (ICD-11 ME65.3) is an unpleasant nettle-like cutaneous sensation triggered by topical preparations or stimuli most people tolerate, the hallmark of sensitive skin syndrome, tested with the lactic acid sting test and linked to small-fiber neuropathy and TRPV1.
Stiripentol
Stiripentol (Diacomit) is a third-generation antiseizure medication, a GABAergic and CYP-inhibiting dioxolane approved from 2007 (EU) and 2018 (FDA) as add-on to clobazam and valproate for refractory tonic-clonic seizures in Dravet syndrome.
Stolen Focus
Stolen Focus: Why You Can't Pay Attention (2022) is Johann Hari's nonfiction book arguing attention loss stems from twelve external causes, from app design to pollution, not personal willpower; a NYT bestseller and 2022 Porchlight Business Book of the Year.
Stoma (medicine)
A stoma, also known as an ostomy, is a surgically created opening that connects a hollow organ such as the bowel or urinary tract to the abdominal surface.
Stomach
Stomach: hollow muscular digestive organ mixing food with acid and enzymes and releasing chyme into the duodenum; also an endocrine and defensive organ. Varies from simple acid sac in humans to fermenting chambers in ruminants; H. pylori causes most gastric cancer.
Stomach cancer
Stomach cancer (gastric cancer), mostly adenocarcinoma of the stomach lining; sixth most common cancer, fifth leading cause of cancer death; mainly caused by Helicobacter pylori; treated by gastrectomy, chemotherapy, and immunotherapy.
Stomach disease
Stomach disease covers gastritis, peptic ulcer, GERD, gastroparesis, and gastric cancer. Key facts: Helicobacter pylori causes ulcers and cancer; Warren and Marshall won the 2005 Nobel Prize; eradication prevents ulcer recurrence.
Stomach rumble
Stomach rumble, or borborygmi (borborygmus), the gurgling noise of gas and fluid moving through the gut during peristalsis; normal in hunger via the migrating motor complex, clinically significant when absent or obstructed.
Stomatitis
Stomatitis, or oral mucositis, is inflammation of the mouth's mucous membranes. Common types are canker sores and cold sores; causes include herpes, Candida, trauma, allergy, and chemotherapy, treated with topical agents.
STONE score
The STONE score is a clinical prediction rule that estimates the probability of a ureteral stone in emergency department patients with suspected renal colic, using five bedside variables.
Stony Brook University Hospital
Stony Brook University Hospital (SBUH), also called Stony Brook Medicine's flagship, is a 628-bed academic medical center in Stony Brook, NY, opened February 18, 1980; Long Island's only tertiary care center and Level 1 Trauma Center, ranked No. 10 in New York State.
Stool culture
Stool culture is a microbiological test that grows bacteria from fecal specimens to identify the pathogens causing bacterial gastroenteritis, including Salmonella, Shigella, Campylobacter, and E. coli O157:H7.