72,234 articles
Claudin
Claudins (CLDNs), tight junction tetraspan membrane proteins named from Latin claudere, form paracellular barriers and ion pores; 27 mammalian members, CLDN18.2 antibody clinically approved as a cancer target.
Claudin-1
Claudin-1 (CLDN1, O95832) is a human 211-aa four-pass tight junction protein sealing the epidermal paracellular barrier and serving with CD81 as hepatitis C virus co-receptor; knockout rats die of skin water loss.
Claudin-11
Claudin-11 (OSP, CLDN11) is a tight junction protein of CNS myelin, inner ear, and testis; 7% of myelin protein; its loss causes deafness, male sterility in mice, and HLD22 leukodystrophy in humans.
Claudin-16
Claudin-16 (paracellin-1), encoded by CLDN16 on 3q28, is a renal tight junction protein of the thick ascending limb that forms a cation-selective paracellular channel with claudin-19 for magnesium and calcium reabsorption; biallelic mutations cause FHHNC.
Claudin-2
Claudin-2 (CLDN2, gene at Xq22.3) is a tight junction protein forming cation- and water-permeable paracellular pores in kidney proximal tubule and small intestine; upregulated in IBD diarrhea and linked to kidney stones and cancer.
Claudin-3
Claudin-3 (CLDN3, 7q11.23; aliases RVP1, CPETR2) is a sealing tight-junction protein prominent in lung, skin, and brain barriers, frequently overexpressed in ovarian, neuroendocrine, and small cell lung cancers, and targeted by antibody ABN501.
Claudin-4
Claudin-4 (CLDN4), a tight junction protein and barrier claudin at 7q11.23, is a CPE receptor, kidney collecting-duct chloride channel partner, and overexpressed diagnostic and therapeutic target in epithelial cancers.
Claudin-5
Claudin-5 (CLDN-5), encoded by the CLDN5 gene, is a tight junction protein that seals the blood–brain barrier, limiting passage of water-soluble molecules under 400 Da.
Claudin-7
Claudin-7 (CLDN7, gene ID 1366, chromosome 17p13.1) is a four-transmembrane tight junction protein of epithelia, essential for intestinal barrier integrity, renal NaCl reabsorption, and dysregulated bidirectionally in cancers.
Claudio A.P. Joazeiro
Claudio A.P. Joazeiro is a molecular biologist and professor at Scripps Research in Florida, known for discovering the Listerin ligase that clears faulty proteins from stalled ribosomes.
Claudio Anasetti
Claudio Anasetti is a transplant physician and hematology researcher who chairs the Blood & Marrow Transplant department at Moffitt Cancer Center, known for trials defining unrelated-donor stem-cell graft selection.
Claudio Basilico
Claudio Basilico is an Italian-born molecular biologist and Professor Emeritus of Microbiology at New York University, known for research on cell proliferation, tumor viruses, and FGF signaling.
Claudio Fiocchi
Claudio Fiocchi is a Brazilian-trained physician and researcher at the Cleveland Clinic known for showing that angiogenesis contributes to inflammatory bowel disease and for his 2011 New England Journal review of ulcerative colitis.
Claudio Hetz
Claudio Andrés Hetz Flores, born 1976 in Chile, is a Chilean neuroscientist and full professor at the University of Chile who studies ER stress in neurodegenerative disease.
Claudio Luchinat
Claudio Luchinat, born in Florence in 1952, is an Italian chemist and Professor Emeritus at the University of Florence known for NMR spectroscopy of paramagnetic metalloproteins and metabolomics.
Claudio Ponticelli
Claudio Ponticelli (1936–2026) was an Italian nephrologist in Milan whose randomized trials of methylprednisolone and chlorambucil in membranous nephropathy, published from 1984, produced the Ponticelli regimen.
Claudio Ronco
Claudio Ronco is an Italian nephrologist, Director of Fondazione IRRIV in Vicenza, known for continuous renal replacement therapy, cardiorenal syndromes, and CARPEDIEM, the first dialysis machine built for newborns.
Claudio Soto
Claudio Soto is a Chilean-American biochemist who invented PMCA, the first technique to replicate infectious prions in a test tube, and directs the Mitchell Center at UTHealth Houston.
Claudio Stern
Claudio D. Stern, born 1954, is a Uruguayan-born developmental biologist at University College London known for research on gastrulation and neural induction in the chick embryo.
Claudio W. Pikielny
Claudio W. Pikielny, also published as Claudio Pikielny, is a molecular biologist known for yeast mRNA splicing work at Brandeis and fruit fly pheromone research at Dartmouth.
Claudiu T. Supuran
Claudiu T. Supuran, born 1962, is a Romanian-born Italian medicinal chemist and full professor at the University of Florence known for carbonic anhydrase inhibitors and SLC-0111.
Claudius Regaud
Claudius Regaud (1870–1940) was a French physician and biologist who founded French radiotherapy, co-founded the Fondation Curie with Marie Curie, and established the dose fractionation principle underlying modern radiation oncology.
Claus Bachert
Claus Bachert (born 1957) is a German ENT physician and allergologist known for work on chronic rhinosinusitis with nasal polyps, Staphylococcus aureus superantigens, and biologic drug treatment.
Claus Christiansen (Danish physician)
Claus Christiansen, born in Aalborg, Denmark in 1942, is a Danish physician and osteoporosis researcher whose 1987 trial showed calcium does not prevent postmenopausal bone loss as effectively as estrogen.
Claus Nerlov
Claus Nerlov is a stem cell biologist and Professor of Stem Cell Biology at the University of Oxford who studies how blood cells form and how leukemia arises.
Claus Niederau
Claus Niederau is a German gastroenterologist and hepatologist, chief physician in Oberhausen, known for hemochromatosis and hepatitis B research, including a 1996 New England Journal of Medicine study.
Claus Scheidereit
Claus Scheidereit is a German molecular biologist who led a signal transduction lab at the Max Delbrück Center in Berlin, known for work on NF-κB in Hodgkin lymphoma.
Claus Vogelmeier
Claus Vogelmeier (born 1956) is a German pulmonologist at Marburg who led the POET-COPD trial, helped lead FLAME, and has chaired the GOLD COPD strategy since 2014.
Clausena
Clausena (Burm.f.), a genus of aromatic shrubs and trees in Rutaceae (citrus family) native from tropical Africa and Asia to Australia; includes wampee (Clausena lansium); known for carbazole alkaloids, coumarins, and essential oils.
Claustrophobia
Claustrophobia: persistent irrational fear of enclosed or confined spaces, a situational specific phobia. Also suffocation-restriction two-factor model; affects about 10% of UK people lifetime; treated with CBT and exposure therapy.