72,234 articles
Daonella
Daonella is an extinct genus of thin-shelled pelagic bivalves (Mojsisovics, 1874; type species Halobia lommeli) dominant in Middle Triassic to Early Carnian Tethyan seas, a biostratigraphic index fossil that evolved into Halobia and lived on soft, soupy seafloors.
Daoy
Daoy, also written DAOY, is a continuous human cell line established in 1985 from a 4-year-old boy's cerebellar medulloblastoma, used as a standard laboratory model of the childhood brain tumor.
DAP3
DAP3 (death associated protein 3, MRPS29/mS29) is a human GTP-binding protein of the mitochondrial ribosome small subunit, essential for mitochondrial translation, embryonic development, apoptosis signaling, and linked to Perrault syndrome and cancer.
Dapa-CKD trial
DAPA-CKD (Dapagliflozin And Prevention of Adverse Outcomes in Chronic Kidney Disease), NCT03036150: AstraZeneca-funded phase 3 trial of dapagliflozin 10 mg vs placebo in 4304 patients with proteinuric CKD stages 2–4, with or without type 2 diabetes; 39% relative risk reduction in the primary renal-cardiovascular composite endpoint.
DAPA-HF trial
DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure), NCT03036124: phase 3 trial of 4,744 patients showing dapagliflozin 10 mg daily reduced worsening heart failure or cardiovascular death (HR 0.74) in HFrEF with or without diabetes.
Dapaconazole
Dapaconazole, sold as Zilt, is an imidazole antifungal developed by Brazil's Biolab as a 2% topical cream for dermatophyte infections, reaching Phase 3 trials and performing non-inferior to ketoconazole and miconazole.
Dapagliflozin
Dapagliflozin, sold as Farxiga and Forxiga, is an SGLT2 inhibitor drug for type 2 diabetes, heart failure, and chronic kidney disease, first approved in 2014.
Daphne Haas-Kogan
Daphne Haas-Kogan is an American radiation oncologist who treats brain tumors and pediatric cancers and chairs radiation oncology at Brigham and Women's Hospital and Massachusetts General Hospital.
Daphne J. Osborne
Daphne J. Osborne (1925–2006) was a British plant physiologist who spent over fifty years studying ethylene and auxin, known for her 1970 Nature paper on leaf abscission and the target cell concept.
Daphne mezereum
Daphne mezereum (mezereon, February daphne) is a toxic, pink-flowered deciduous shrub of Thymelaeaceae native from Europe to SW Siberia and N Iran, containing mezerein and daphnetoxin.
Daphne Preuss
Daphne Preuss is an American plant geneticist and entrepreneur known for defining Arabidopsis centromeres, discovering how sperm cells reach and fuse with egg cells, and founding Chromatin Inc.
Daphne W. Bell
Daphne W. Bell is a Northern Ireland-born cancer geneticist and senior investigator at the National Human Genome Research Institute, known for defining genomic drivers of aggressive endometrial cancer.
Daphnia
Daphnia (water flea), planktonic cladoceran crustacean genus with cyclic parthenogenesis; keystone freshwater grazer and leading model organism in ecotoxicology, ecology, and evolutionary genomics; key species Daphnia magna and Daphnia pulex.
DAPI
DAPI (4′,6-diamidino-2-phenylindole) is a blue-fluorescent AT-minor-groove DNA stain, excitation/emission 358/461 nm, used for fixed-cell nuclear counterstaining, flow cytometry viability, and DNA content analysis; less cell-permeable than Hoechst 33342.
Dapivirine
Dapivirine (DPV-VR, dapivirine vaginal ring 25 mg): an NNRTI antiretroviral delivered by a monthly silicone vaginal ring for HIV prevention in women; EMA Article 58 opinion 2020, WHO prequalified and recommended 2021, ~27–31% efficacy in phase 3 trials.
DAPK1
DAPK1 (death-associated protein kinase 1, DAPK) is a Ca2+/calmodulin-regulated serine/threonine kinase discovered in 1995 by Adi Kimchi; a tumor suppressor regulating apoptosis and autophagy, implicated in cancer, Alzheimer's disease, and stroke.
Dapoxetine
Dapoxetine (Priligy) is a short-acting SSRI taken 1-3 hours before sex for premature ejaculation; approved in Europe and elsewhere but not the USA, with 2.5-3.0-fold IELT increases in phase 3 trials.
Dapper
Dapper (Dact, Frodo) is a chordate-specific family of scaffold proteins (DACT1-3 in humans and mice) that bind Dishevelled via a C-terminal PDZ-binding motif and regulate Wnt and TGF-β signaling in development and cancer.
Daprodustat
Daprodustat (Jesduvroq, GSK1278863) is an oral HIF prolyl hydroxylase inhibitor approved in 2023 by the FDA for anemia of chronic kidney disease in adults on dialysis, with a boxed thrombotic-event warning.
Dapsone
Dapsone (DDS, 4,4'-diaminodiphenylsulfone) is a sulfone antibiotic and anti-inflammatory drug, first-line with rifampicin and clofazimine in WHO leprosy multidrug therapy and used topically for acne.
DAPT score
The DAPT score is a clinical tool that predicts whether extending dual antiplatelet therapy after coronary stenting will help or harm, introduced by Robert W. Yeh in 2016.
Daptomycin
Daptomycin (Cubicin) is a cyclic lipopeptide antibiotic from Streptomyces roseosporus, FDA-approved 2003/2006 for Gram-positive skin infections and S. aureus bacteremia, dosed once daily, not for pneumonia.
DARA_T_ALL trial
DARA_T_ALL (NCT07021677) is a phase 2 single-arm Tata Memorial Centre trial testing daratumumab, an anti-CD38 antibody, to eradicate MRD in adults with T-ALL still MRD-positive after induction; 18 patients, one Indian site, started 2023, no results posted yet.
Darapladib
Darapladib (SB-480848, CHEMBL204021) is an oral selective Lp-PLA2 inhibitor developed by GSK for atherosclerosis. Its phase 3 trials STABILITY and SOLID-TIMI 52 failed to reduce cardiovascular events despite about 65% enzyme inhibition.
Daratumumab
Daratumumab (Darzalex, Darzalex Faspro) is a CD38-targeting human IgG1κ monoclonal antibody for multiple myeloma and AL amyloidosis, FDA-approved since November 2015, improving survival in newly diagnosed and relapsed disease.
Daratumumab regimen
A daratumumab regimen is a multiple myeloma treatment combining the CD38 antibody daratumumab with backbone drugs such as dexamethasone, bortezomib, or lenalidomide, across newly diagnosed and relapsed disease.
Daraxonrasib
Daraxonrasib, marketed as Rasonque and developed as RMC-6236, is an oral pan-RAS inhibitor from Revolution Medicines, approved by the FDA in August 2026 for metastatic pancreatic adenocarcinoma after prior therapy.
Darbepoetin alfa
Darbepoetin alfa (Aranesp) is a long-acting erythropoiesis-stimulating agent for anemia of chronic kidney disease and cancer chemotherapy, FDA approved 2001, with a 3-fold longer half-life than epoetin alfa.
Darell D. Bigner
Darell D. Bigner is an American physician-scientist at Duke University who founded its Preston Robert Tisch Brain Tumor Center and developed the poliovirus therapy PVSRIPO.
Daren K. Heyland
Daren K. Heyland is a Canadian critical care physician and clinical epidemiologist at Queen's University in Kingston, Ontario, known for the NUTRIC score and the RE-ENERGIZE trial.