72,234 articles
DBA/2J
DBA/2J (D2) is a Jackson Laboratory inbred mouse strain descended from the first inbred line, DBA, begun by Clarence Little in 1909; named for dilute, brown, non-agouti coat genes; prone to early hearing loss, audiogenic seizures, and glaucoma-like eye disease.
DBAR study
DBAR study: Diamond Blackfan Anemia Registry of North America (NCT00106015), a Northwell Health patient registry since 1991 with over 850 DBA patients, known for quantifying elevated cancer risk in DBA.
Dbpr-108
DBPR108 (prusogliptin) is a once-daily DPP-4 inhibitor for type 2 diabetes, developed by Taiwan's NHRI and approved by China's NMPA in January 2025; phase 3 trials showed HbA1c reductions of about 0.6-0.7%, non-inferior to sitagliptin.
dC-dT-MDS trial
dC-dT-MDS trial (DC-DT-MDS022021): phase 2 single-arm McGill University Health Centre trial of deoxycytidine/deoxythymidine for mitochondrial DNA depletion disorders, including POLG-related disease, with improved NMDS scores and lower GDF-15.
DCD
DCD (dermcidin), HGNC:14669 at 12q13.2, is a human gene encoding a 110-amino-acid secreted precursor processed in sweat into anionic and cationic antimicrobial peptides, plus N-terminal survival and cachexia peptides.
DCIS trial
DCIS trial (NCT03002766): Milan phase 2 prospective study of 224 women testing a margin-width plus risk-factor score to omit radiotherapy after breast-conserving surgery for ductal carcinoma in situ; 1.138% yearly recurrence with 57.6% avoiding radiation.
DCLK1
DCLK1 (doublecortin-like kinase 1, HGNC:2700, Gene ID 9201) encodes a microtubule-associated serine/threonine kinase with DCX domains, a tuft cell and cancer stem cell marker overexpressed in gastrointestinal cancers and a targeted-therapy candidate.
DCLRE1C
DCLRE1C (Artemis, SNM1C) is a human gene at 10p13 encoding a metallo-beta-lactamase nuclease for V(D)J recombination and NHEJ DNA repair; null mutations cause radiosensitive T-B-NK+ SCID, hypomorphic ones Omenn syndrome.
DCTN1
DCTN1 (dynactin subunit 1, p150Glued), gene at 2p13 encoding the largest subunit of the dynein-activating dynactin complex; mutations cause Perry syndrome, dHMN7B, FTD, ALS, and PSP.
DDB1
DDB1 (damage-specific DNA binding protein 1, UV-DDB1) is a 127 kDa human adaptor protein with three WD40 propellers that links CUL4A/B Cullin-RING ligases to DCAF substrate receptors and, with DDB2, recognizes UV DNA lesions in nucleotide excision repair.
DDB1- and CUL4-associated factor
DDB1- and CUL4-associated factors (DCAFs) are the WD40-repeat substrate receptors of the CUL4-DDB1 (CRL4) E3 ubiquitin ligase; over 50 exist in humans, including DDB2, DCAF2, DCAF1, and the drug target cereblon.
Ddc1
Ddc1 (DNA damage checkpoint protein 1, DDC1_YEAST) is the Saccharomyces cerevisiae Rad9-ortholog subunit of the Rad17/Mec3/Ddc1 (9-1-1) checkpoint clamp, loaded by Rad24-RFC, recruited to DNA damage sites, and a direct activator of the Mec1 kinase.
DDIT3
DDIT3 (CHOP, GADD153) is a human 12q13.3 gene encoding a C/EBP-family bZIP stress-response transcription factor that promotes apoptosis during ER stress and forms FUS or EWSR1 fusion oncogenes diagnostic of myxoid liposarcoma.
DDIT4
DDIT4 (REDD1, RTP801, Dig2) is a human chromosome 10q22.1 stress-responsive gene encoding a 232-amino-acid inhibitor of mTORC1 via the TSC1/TSC2-RHEB axis, induced by hypoxia and DNA damage and implicated in cancer prognosis, diabetes, and venous malformation.
DDK kinase regulatory subunit Dbf4
Dbf4 (dumbbell former 4; human ASK) is the regulatory subunit of Cdc7 forming DDK, the kinase that fires eukaryotic replication origins; conserved motifs N, M, C bind and activate Cdc7.
DDOST-CDG
DDOST-CDG (CDG-Ir, OMIM 614507) is an ultra-rare autosomal recessive congenital disorder of N-linked glycosylation caused by DDOST mutations, with hypotonia, developmental delay, and hepatic dysfunction.
DDR1
DDR1 (discoidin domain receptor tyrosine kinase 1, Q08345) is a human collagen-binding receptor tyrosine kinase with five splice isoforms, slow sustained activation, roles in fibrosis and cancer, and no approved drugs yet.
DDR2
DDR2 (discoidin domain receptor tyrosine kinase 2, HGNC:2731) is a human chromosome 1q23.3 gene encoding an 855-amino-acid collagen-activated receptor tyrosine kinase required for bone development; mutations cause SMED-SL and Warburg-Cinotti syndrome.
DDX39B
DDX39B (BAT1, UAP56), DExD-box helicase 39B, is a human DEAD-box RNA helicase gene at 6p21.33 in the MHC class III region, essential for pre-mRNA splicing, TREX-mediated mRNA export, and R-loop unwinding.
DDX3X
DDX3X (DEAD-box helicase 3 X-linked) is an X-linked ATP-dependent RNA helicase gene at Xp11.4 with a Y-linked paralog DDX3Y. Mutations cause DDX3X syndrome, up to 3% of intellectual disability in females, and DDX3X acts mainly as a tumour suppressor in cancer.
DDX41
DDX41 (DEAD-box helicase 41), gene at 5q35.3 encoding a 622-aa RNA helicase involved in splicing, ribosome biogenesis, and innate immunity; germline mutations cause the most common hereditary predisposition to adult-onset MDS/AML via a two-hit model with somatic p.R525H.
DDX5
DDX5 (p68) is a human DEAD-box RNA helicase gene at 17q23.3, distinct from the p68 calcium-binding protein. It drives RNA metabolism and transcriptional coactivation, is overexpressed in most cancers, and is a therapeutic target (FL118, RX-5902).
DDX6
DDX6 (RCK/p54, DEAD-box helicase 6) is a conserved ATP-dependent RNA helicase gene at 11q23.3 that represses translation, promotes mRNA decay, assembles P-bodies, and is required for microRNA silencing and implicated in leukemia and other cancers.
De Barsy syndrome
De Barsy syndrome (DBS, ARCL3, OMIM 219150/614438) is an ultra-rare autosomal recessive progeroid cutis laxa disorder with corneal clouding, growth retardation, intellectual disability, and athetoid movements, linked to PYCR1 or ALDH18A1 in some cases.
De materia medica (Περὶ ὕλης ἰατρικῆς)
De materia medica (Περὶ ὕλης ἰατρικῆς) is a first-century Greek pharmacological treatise by Pedanius Dioscorides that dominated European and Middle Eastern medicine for sixteen centuries.
De novo enzyme design
De novo enzyme design is the computational creation of protein catalysts from scratch, modeling an active site for a chosen reaction and building a scaffold around it.
De novo peptide sequencing
De novo peptide sequencing is a computational mass spectrometry method that infers a peptide's amino acid sequence directly from its MS/MS spectrum, without searching a protein database.
De novo sequence assembly
De novo sequence assembly is a bioinformatics method that reconstructs complete genome or transcript sequences directly from sequencing reads without a reference genome, producing contigs, scaffolds, or transcripts.
De novo transcriptome assembly
De novo transcriptome assembly is a bioinformatics method that reconstructs transcript sequences directly from RNA sequencing reads without a reference genome, using tools such as Trinity.
De Quervain syndrome
De Quervain syndrome, or de Quervain's tenosynovitis, is stenosing tenosynovitis of the wrist's first extensor compartment (APL and EPB tendons), named after Fritz de Quervain; corticosteroid injection is first-line, surgery when it fails.