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Denture Retention
Denture retention: resistance of a removable denture to vertical dislodgement, from saliva film viscosity, base adaptation, border seal, adhesives, or implant attachments. Distinct from denture stability.
Denture, Complete, Immediate
Denture, Complete, Immediate: a complete denture placed immediately after tooth extraction as a temporary functional and cosmetic prosthesis during healing, later replaced by a permanent denture; MeSH term since 1965.
Denture, Complete, Lower
Denture, Complete, Lower: a removable prosthesis replacing all mandibular teeth, tissue-supported only. Mean longevity 8.6 years, poorer stability than upper dentures; two-implant overdenture is the main alternative.
Denture, Complete, Upper
Complete upper denture (maxillary complete denture): removable prosthesis replacing all maxillary teeth, retained by mucosal suction and posterior palatal seal; alternatives include implant overdentures and fixed implant prostheses.
Denture, Partial, Fixed
Denture, Partial, Fixed, also called fixed partial denture, fixed bridge, or FDP/FDP bridge, is a cemented dental prosthesis replacing missing teeth on prepared teeth, roots, or implants; 5-year survival about 94%, 10-year about 89%.
Denture, Partial, Fixed, Resin-Bonded
Resin-bonded fixed partial denture (Maryland bridge, resin-bonded bridge): a minimally invasive fixed dental prosthesis bonded to adjacent teeth with resin cement. 5-year survival about 87.7%; debonding is the main complication.
Denture, Partial, Immediate
Denture, Partial, Immediate (MeSH D003831): a partial denture built before extraction and inserted immediately after removal of the natural teeth, worn during up to 6 months of healing, then replaced by a fitted partial denture.
Denture, Partial, Removable
Removable partial denture (RPD): a patient-removable prosthesis replacing one or more missing teeth in a partially edentulous arch; first documented 1711, clasps from 1746, retention loss the leading complication.
Denture, Partial, Temporary
Denture, Partial, Temporary (interim removable partial denture, flipper): an acrylic partial denture for short-term or emergency tooth replacement until a definitive prosthesis; MeSH D003833, introduced 1965.
Dentures
Dentures (false teeth) are removable acrylic, nylon, or metal appliances replacing missing teeth, complete or partial. Covers fabrication, care, implant-supported alternatives, and history from ancient Egypt to CAD/CAM.
Denufosol
Denufosol (denufosol tetrasodium, INS37217), an inhaled P2Y2 receptor agonist developed by Inspire Pharmaceuticals to hydrate airways in cystic fibrosis; discontinued in 2011 after the TIGER-2 Phase 3 trial failed to confirm lung-function benefit.
Deoxycholic acid
Deoxycholic acid (DCA), a secondary bile acid made by gut bacteria from cholic acid via the bai operon; FXR/TGR5 ligand, cancer-linked, and the drug Kybella for submental fat.
Deoxycytidylate deaminase
Deoxycytidylate deaminase (dCMP deaminase, DCTD, EC 3.5.4.12) is a zinc-dependent cytidine deaminase superfamily hexameric enzyme converting dCMP to dUMP for thymidylate synthesis, allosterically activated by dCTP and inhibited by dTTP.
Deoxycytidylate hydroxymethylase
Deoxycytidylate hydroxymethylase (dCMP hydroxymethylase, EC 2.1.2.8, T4 gene 42 product gp42) is the first virus-encoded enzyme discovered; a thymidylate synthase homodimer homologue that converts dCMP to 5-hydroxymethyl-dCMP using methylenetetrahydrofolate, enabling glucosylated, restriction-resistant T4 phage DNA.
Deoxyhypusine synthase
Deoxyhypusine synthase (DHS, DHPS), the NAD+-dependent enzyme catalyzing the first step of eIF5A hypusination, transferring spermidine's aminobutyl group to Lys50; inhibited by GC7 (Ki 10 nM) and newer allosteric inhibitors.
Deoxyribonuclease
Deoxyribonuclease (DNase), EC 3.1.-, any enzyme hydrolyzing phosphodiester bonds in DNA. Two families: cation-dependent neutral-pH DNase I and cation-independent acidic DNase II; dornase alfa treats cystic fibrosis.
Deoxyribonuclease II
Deoxyribonuclease II (DNase II, acid DNase, DNase IIα) is a lysosomal endonuclease active at pH ~5.2 without divalent cations, leaving 3'-phosphate/5'-OH ends; essential for apoptotic and erythroid DNA clearance, lethal when knocked out in mice.
Deoxyribose
Deoxyribose (2-deoxy-D-ribose, thyminose), C5H10O4, is the pentose sugar of DNA, ribose lacking its 2-hydroxyl; covers structure, stability, metabolism, DNA damage, and prebiotic research.
Deoxyuridine
Deoxyuridine is a pyrimidine 2'-deoxyribonucleoside consisting of uracil attached to deoxyribose; its monophosphate is the immediate precursor of thymidylate, and it also grounds the deoxyuridine suppression test for vitamin B12 and folate deficiency.
Deoxyuridine triphosphate nucleotidohydrolase
Deoxyuridine triphosphate nucleotidohydrolase (dUTPase, EC 3.6.1.23) hydrolyzes dUTP to dUMP and pyrophosphate, preventing uracil incorporation into DNA and supplying the dTMP precursor; typically homotrimeric, essential, and a drug target.
DEP domain
DEP domain (Dishevelled, Egl-10, Pleckstrin domain), an about 80-100 residue globular signaling domain recruiting proteins to membranes; found in Dishevelled, RGS proteins, and bacteria; binds Frizzled and GPCR tails.
Department of Agriculture, Forestry and Fisheries (South Africa)
Department of Agriculture, Forestry and Fisheries (DAFF), South African national department (2009–2019) covering agriculture, forestry and fisheries; disestablished 2019, functions split to DALRRD and DFFE.
Department of Animal Husbandry and Dairying
Department of Animal Husbandry and Dairying (DAHD), Indian government department under the Ministry of Fisheries, Animal Husbandry and Dairying, founded 1991; runs NADCP, LHDCP, livestock census, and dairy development schemes from Krishi Bhawan, New Delhi.
Department of Fisheries and Oceans
The Department of Fisheries and Oceans, also known as Fisheries and Oceans Canada, is a federal department of the Government of Canada. It manages fisheries and marine sciences.
Department of forests herbarium
Department of Forests herbarium, also called the Alevkaya or North Cyprus Herbarium, a pressed-plant collection in the Kyrenia Mountains founded with botanist Deryck Viney and opened 9 November 1989 as North Cyprus's first herbarium, with about 450 species at opening.
Department of Health (Dublin, IE)
The Department of Health (An Roinn Sláinte) is the Irish government department responsible for health policy, established in 1947 and headquartered in Dublin, overseeing bodies including the Health Service Executive.
Department of Health (Philippines)
Department of Health (Kagawaran ng Kalusugan, DOH), the Philippine executive department running national health policy, hospitals, and Universal Health Care implementation; founded 1898, 2026 budget Php 253.8 billion, led by Secretary Edwin Mercado.
Department of Health (Pretoria, ZA)
The National Department of Health is South Africa's government department responsible for the national health system, headquartered in Pretoria and guided by the National Health Act of 2003.
Department of Health (Taipei, TW)
Department of Health, Taipei City Government (臺北市政府衛生局), the city's first-level public health agency with 9 divisions and 6 offices, overseeing Taipei City Hospital and 12 district health centers; reorganized in 2005 and 2017.
Department of Health (Vitoria-Gasteiz, ES)
Department of Health (Departamento de Salud, Osasun Saila) of the Basque Government, headquartered in Vitoria-Gasteiz. It directs Basque health policy and Osakidetza-Servicio Vasco de Salud; minister Alberto Martínez Ruiz since June 2024.