72,234 articles
Department of Health and Social Care
The Department of Health and Social Care (DHSC) is the UK government department responsible for England's health and care system, with planned spending of £215.6 billion in 2025-26.
Depatuxizumab mafodotin
Depatuxizumab mafodotin (depatux-m, ABT-414) is AbbVie's anti-EGFR antibody-drug conjugate carrying MMAF, tested in EGFR-amplified glioblastoma; INTELLANCE-1 phase III showed no overall survival benefit and development was discontinued.
Depei Liu (刘德培)
Depei Liu (刘德培), born 1950 in Anhui, is a Chinese biochemist and molecular biologist known for globin gene regulation, gene therapy, and cardiovascular disease genetics research.
Depemokimab
Depemokimab (trade name Exdensur) is a GSK monoclonal antibody that blocks interleukin-5, given twice yearly for severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps.
Dependent personality disorder
Dependent personality disorder (DPD), a Cluster C personality disorder: pervasive need to be taken care of, submissive clinging behavior, fear of separation; five of eight DSM-5-TR criteria; prevalence about 0.5–0.6%; treated with psychotherapy, no approved drugs.
Depersonalization
Depersonalisation, also called depersonalization-derealization disorder (DPD, DPDR, ICD-11 6B66), is a dissociative disorder of feeling detached from one's self; coined 1898, affects 1-2% of the population.
Depersonalization-derealization disorder
Depersonalization-derealization disorder, also known as DPDR, is a dissociative disorder causing persistent feelings of detachment from oneself or one's surroundings, usually triggered by severe stress.
Depolarization
Depolarization is the shift of a cell's membrane potential toward less negative values, mainly via cation influx. Key in action potentials (−70 mV to +30 mV), EPSPs, depolarizing GABA, and spreading depolarization in brain injury.
Deposits on teeth
Deposits on teeth (accretions; ICD-10 K03.6, ICD-11 DA08.4) cover dental calculus or tartar, plaque, materia alba, and stains; calculus is mineralized plaque affecting about 90% of people, removed by scaling.
Deprescribing
Deprescribing is the supervised withdrawal of inappropriate medications to manage polypharmacy; over 40% of adults 75 and older take five or more drugs, and about 50% of older adults take at least one potentially inappropriate medication.
DEPRESS/PHQ-9 study
DEPRESS/PHQ-9 (NCT06702761) is an Al-Nahrain University observational cross-sectional study estimating prevalence and severity of depression among cardiothoracic surgery healthcare workers in Baghdad, Iraq, using the self-administered PHQ-9, with about 200 participants recruited at one Baghdad site from December 2024.
Depressant
Depressant (CNS depressant): a drug class slowing brain activity, also called sedatives or tranquilizers; includes benzodiazepines, barbiturates, and sleep medicines used for insomnia, anxiety, panic attacks, and seizures, with GABA_A mechanisms and overdose risks.
Depressariidae
Depressariidae, the flat-bodied moths, is a Gelechioidea moth family established by Meyrick in 1883 with about 2,300 species, broad flat-held wings of 10-25 mm, and plant-feeding larvae; formerly a subfamily of Oecophoridae or Elachistidae, now a separate family.
Depression (mood)
Depression (depressive disorder) is a common mental disorder involving persistent depressed mood or loss of interest for at least two weeks; about 322 million people affected, more common in women, treatable with psychotherapy and antidepressants.
Depurination
Depurination is the hydrolytic loss of a purine base (adenine or guanine) from DNA, creating about 10,000 abasic sites per human cell each day, repaired by base excision repair.
Depyrimidination
Depyrimidination is the loss of a pyrimidine base (cytosine or thymine) from DNA by glycosidic bond cleavage, creating an apyrimidinic AP site; it occurs spontaneously and enzymatically via pyrimidine-specific DNA glycosylases initiating base excision repair.
Dequalinium
Dequalinium (dequalinium chloride, Dequadin, Fluomizin) is a bis-quaternary ammonium topical antiseptic used since the 1950s in sore-throat lozenges and, as 10 mg vaginal tablets, for bacterial vaginosis.
Der nervenarzt
Der Nervenarzt (ISSN 0028-2804) is a German-language peer-reviewed journal of neurology and psychiatry founded in 1928, published by Springer Medizin, official DGPPN organ since 1955, editor Frank Schneider.
Der Schmerz
Der Schmerz is a German-language, bimonthly, peer-reviewed pain medicine journal published by Springer since 1987; official organ of the German, Austrian, and Swiss pain societies; ISSNs 0932-433X and 1432-2129.
Derbidae
Derbidae, derbid planthoppers (Spinola, 1839), a family of Fulgoroidea planthoppers with 166 genera and 1,722 species; diagnosed by a short apical rostrum segment, classified in three subfamilies, and studied as possible palm phytoplasma vectors.
Derealization
Derealization is the feeling that one's surroundings are unreal, dreamlike, or detached, with intact reality testing; classified with depersonalization as depersonalization/derealization disorder (DPDR), a dissociative disorder affecting about 1 to 2% of people, usually beginning in adolescence, and treated mainly with psychotherapy.
Derek A. T. Cummings
Derek A. T. Cummings, also published as Derek Cummings, is an infectious-disease epidemiologist known for modeling dengue and influenza, and a Bloomberg Distinguished Professor at Johns Hopkins.
Derek C. Angus
Derek Angus is a Scottish-born physician and critical care researcher at the University of Pittsburgh who led its critical care department and led landmark sepsis trials.
Derek Denton
Derek Denton (1924–2022) was an Australian research physiologist, founding director of the Howard Florey Institute in Melbourne, whose sheep and chimpanzee studies established salt appetite as innate and linked salt intake to blood pressure.
Derek E. G. Briggs
Derek E. G. Briggs is a paleontologist at Yale University and a Peabody Museum curator since 2003, known for work on the Burgess Shale and the Tully monster.
Derek H. Oakley
Derek H. Oakley is an American neuropathologist and stem cell biologist at Harvard Medical School and Massachusetts General Hospital who studies Alzheimer's disease using patient-derived stem cells.
Derek J. Hausenloy
Derek J. Hausenloy, also published as Derek John Hausenloy, is a cardiologist and professor at University College London and Duke-NUS Medical School, known for research on cardioprotection and ischaemic conditioning.
Derek M. Yellon
Derek M. Yellon is a cardiologist, Professor of Molecular & Cellular Cardiology at University College London, and Director of the Hatter Cardiovascular Institute, known for defining the RISK pathway in myocardial protection.
Derek R. Lovley
Derek R. Lovley, also published as Derek Lovley, is an American microbiologist who discovered the metal-respiring bacterium Geobacter in 1987 and founded electromicrobiology, known for microbial nanowires and uranium bioremediation.
Derek van der Kooy
Derek van der Kooy is a professor of molecular genetics at the University of Toronto known for his 2000 discovery of retinal stem cells in the adult mammalian eye.