72,234 articles
Filariasis due to Wuchereria bancrofti
Bancroftian filariasis, lymphatic filariasis due to Wuchereria bancrofti, a mosquito-borne nematode causing 90% of LF cases; lymphoedema, hydrocele, and a global MDA elimination program.
Filensin
Filensin (BFSP1; formerly CP95, CP115, CP94) is an intermediate filament protein expressed only in lens fiber cells, where with CP49 (phakinin) it forms beaded filaments essential for lens transparency; mutations cause juvenile-onset cataract.
Filgotinib
Filgotinib (Jyseleca, GS-6034/GLPG0634) is an oral preferential JAK1 inhibitor approved in the EU, UK, and Japan for rheumatoid arthritis and ulcerative colitis, dosed once daily as 100 or 200 mg maleate tablets.
Filgrastim
Filgrastim (r-metHuG-CSF, Neupogen) is a recombinant, non-glycosylated 175-amino-acid human G-CSF made in E. coli, approved in the US in 1991 to treat neutropenia, mobilize stem cells, and treat radiation exposure; biosimilars include Zarxio.
Filibuvir
Filibuvir (PF-00868554), a Pfizer non-nucleoside inhibitor of the HCV NS5B polymerase binding the thumb 2 site, reached phase 2 for genotype 1 hepatitis C before development was discontinued in 2013.
Filip Swirski
Filip Swirski is a Polish-born immunologist known for work on monocytes and macrophages in atherosclerosis; since 2021 he has directed the Cardiovascular Research Institute at Mount Sinai in New York.
Filipe Borges
Filipe Borges is a plant molecular biologist who leads an epigenetics team at INRAE's Institut Jean-Pierre Bourgin near Paris, studying small RNAs and transposon silencing in plant reproduction.
Filipendula
Filipendula (meadowsweet, dropwort), a Rosaceae genus of about 10–15 perennial herbs of the temperate Northern Hemisphere; basal genus of Rosoideae, diverging about 82.88 Ma; includes medicinal F. ulmaria.
Filippi syndrome
Filippi syndrome (OMIM 272440) is an extremely rare autosomal recessive disorder caused by CKAP2L variants, marked by microcephaly, syndactyly of fingers and toes, growth retardation, distinctive facies, and intellectual disability; fewer than 50 cases reported.
Filippo Bottazzi
Filippo Bottazzi (1867–1941) was an Italian comparative physiologist and professor at the University of Naples, commonly credited as the father of Italian biochemistry; he discovered the hemocatatonetic function of the spleen.
Filippo Crea
Filippo Crea, born in Cosenza, Italy, in 1953, is an Italian cardiologist known for establishing that ischemic heart disease involves the coronary microcirculation, not only large-artery narrowing.
Filippo Giancotti
Filippo G. Giancotti (1958–2023) was an Italian-born cancer biologist known for work on integrin signaling and metastatic dormancy, holding posts at Sloan Kettering, MD Anderson, and Columbia.
Filippo M. Rijli
Filippo M. Rijli is an Italian developmental biologist who leads the Laboratory of Developmental Neuroepigenetics at the Friedrich Miescher Institute in Basel, studying Hox genes and Polycomb regulation in cranial neural crest.
Filippo Mancia
Filippo Mancia is an Italian structural biologist and professor at Columbia University who determines atomic structures of membrane proteins, including the Wnt carrier WLS and the choline transporter FLVCR2.
Filippo Pietrantonio
Filippo Pietrantonio is an Italian medical oncologist who heads gastrointestinal oncology at the Istituto Nazionale dei Tumori in Milan, known for the CodeBreaK 300 trial in KRAS G12C-mutated colorectal cancer.
Filmy ferns of the British Isles
The filmy ferns of the British Isles are three Hymenophyllaceae species, Tunbridge filmy-fern, Wilson's filmy fern, and the Killarney fern, restricted to humid western localities.
Filoviridae
Filoviridae, the filovirus family, is a group of filamentous negative-sense RNA viruses in the order Mononegavirales with 13.1–20.9 kb genomes, 9 genera infecting fish, mammals, and reptiles, including the lethal human pathogens Ebola virus and Marburg virus.
Filter feeder
A filter feeder is an animal that strains food from water flowing through its body, a strategy seen from sponges and oysters to baleen whales, which evolved it from toothed ancestors.
Filtering Surgery
Filtering surgery (glaucoma filtration surgery, trabeculectomy) creates a fistula draining aqueous humor to a subconjunctival bleb to lower IOP; developed from De Wecker's 1882 fistula to Cairns' 1968 guarded trabeculectomy, now alongside tube shunts and MIGS.
FimA-like
FimA-like pilins are a Bacteroidia protein superfamily forming type V pili, with transthyretin-like folds and protease-mediated donor-strand exchange assembly, distinct from chaperone-usher and Gram-positive pili.
Fimasartan
Fimasartan (Kanarb, BR-A-657) is a Korean-developed angiotensin II type 1 receptor blocker for hypertension, the ninth ARB approved, dosed 60-120 mg once daily, with 18.6% bioavailability and mainly biliary-fecal elimination.
Fimbrial agglutination
Fimbrial agglutination: in gynecology, adhesive bridges of fallopian tube fimbriae across the ostium (ICD-11 GA17.1), linked to infertility and endometriosis; in microbiology, fimbriae-mediated cell clumping.
Fimbrial protein TafF
TafF (HAH_0238) is a hypothetical protein of Haloarcula hispanica predicted to anchor tat-fimbriae (tafi), Tat-secreted haloarchaeal surface filaments, to the cell wall; homologs occur only in tafA-bearing archaea, and its function is untested by knockouts.
Fimbristylis
Fimbristylis (fringe rush, fimbry) is a conserved genus of about 313 sedge species in Cyperaceae, tribe Abildgaardieae, established by Vahl in 1805; cosmopolitan, C4, with deciduous fringed styles and weaving species such as F. umbellaris.
Fimbrium subunit FimB/Mfa2/Mfa3
FimB/Mfa2/Mfa3 are subunits of Porphyromonas gingivalis fimbriae: FimB and Mfa2 are outer-membrane anchors and elongation terminators of the FimA and Mfa1 fimbriae, and Mfa3 is the tip adaptor protein of the Mfa1 fimbrial tip complex.
Fin regeneration in zebrafish
Fin regeneration in zebrafish is the ability of adult zebrafish to fully rebuild an amputated caudal fin in two to three weeks through wound healing, blastema formation, and outgrowth.
Fin whale
Fin whale (Balaenoptera physalus), also finback or razorback: the second largest whale after the blue whale, up to 24 m and 73 t. IUCN Vulnerable, ESA endangered; over 725,000 caught in the Southern Hemisphere 1905-76; still hunted by Iceland and Japan.
Finafloxacin
Finafloxacin (Xtoro), a pH-activated fourth-generation fluoroquinolone otic suspension 0.3%, treats acute otitis externa; FDA approved December 17, 2014, later discontinued, now under Fonseca Biosciences.
Finasteride
Finasteride (Propecia, Proscar) is a type II 5α-reductase inhibitor lowering DHT ~70%; used at 5 mg for BPH and 1 mg for male pattern hair loss, with PSA-lowering, sexual and psychiatric side-effect debates.
Finch
Finch: true finches are seed-eating passerine birds of Fringillidae with conical bills, found worldwide except Australia. Darwin's finches and zebra finches are not finches but tanagers and waxbills; HMGA2 links to Galápagos beak evolution.