edgepedia

Life and health

72,234 articles

Henry T. Lynch

Henry T. Lynch, also known as Henry Lynch, was an American cancer geneticist at Creighton University who established that common cancers can be inherited; Lynch syndrome is named after him.

Henry Van Peters Wilson

Henry Van Peters Wilson (1863–1939) was an American zoologist at the University of North Carolina known for showing in 1907 that dissociated sponge cells reassemble into complete animals.

Henry W. Foster Jr

Henry W. Foster Jr. (1933–2022) was an American obstetrician-gynecologist and medical educator at Meharry Medical College in Nashville, known for reducing infant mortality and his contested 1995 Surgeon General nomination.

Henry Wieghorst Nissen

Henry Wieghorst Nissen (1901–1958) was an American psychobiologist at the Yale and Yerkes Laboratories of Primate Biology, director from 1955, known for his 1931 chimpanzee field study.

Hensin Tsao

Hensin Tsao is a dermatologist and melanoma genetics researcher who directs the Melanoma and Pigmented Lesion Center at Massachusetts General Hospital and teaches at Harvard Medical School.

Heo Jun

Heo Jun (허준, 1539–1615) was a Joseon-dynasty court physician who rose to head of the royal clinic and compiled the Donguibogam, Korea's representative traditional medical text.

Hep 3B2.1-7

Hep 3B2.1-7 (Hep3B, ATCC HB-8064, CVCL_0326) is a human hepatocellular carcinoma cell line from an 8-year-old boy, established 1976, HBV genome-integrated, AXIN1/RB1 mutated, second most used HCC line after HepG2.

HEp-2

HEp-2 (H.Ep.-2, CVCL_1906, ICLAC-00007) is a human cancer cell line described in 1954 as laryngeal carcinoma but shown in 1967 to be a HeLa derivative; still widely used for ANA immunofluorescence testing and virus culture.

Hep-G2

Hep-G2 (HepG2, CVCL_0027, ATCC HB-8065) is a human liver cancer cell line established in 1975 from a 15-year-old male, reclassified from hepatocellular carcinoma to hepatoblastoma, widely used in drug metabolism and hepatotoxicity research despite very low CYP enzyme expression.

Hepacivirus

Hepacivirus (Orthohepacivirus) is a Flaviviridae virus genus whose type species, hepatitis C virus (HCV), causes chronic bloodborne hepatitis; other species infect horses, rodents, bats, cows, and primates.

Hepadnaviridae

Hepadnaviridae (hepatitis B-type viruses): family of small enveloped DNA viruses, 3.0–3.4 kb partially double-stranded genomes, replicating by reverse transcription in hepatocytes; five genera, HBV prototype, ancient fish-virus origins.

HepaRG

HepaRG (Hepa-RG, CVCL_9720) is a human hepatoma cell line from a female HCV/hepatocarcinoma patient, established 2002; a bipotent progenitor line that differentiates with DMSO into hepatocyte-like cells expressing CYP enzymes and supporting HBV/HDV infection.

Heparin

Heparin, a sulfated glycosaminoglycan anticoagulant discovered in 1916 by Jay McLean, potentiates antithrombin to inhibit thrombin and factor Xa; forms include unfractionated heparin and low-molecular-weight heparins, used for thrombosis, surgery, and dialysis, with recurring shortages tied to porcine sourcing.

Heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT), an immune adverse reaction to heparin mediated by anti-PF4/heparin IgG, causes thrombocytopenia with paradoxical thrombosis; diagnosed via 4Ts score, immunoassays, and functional assays, and treated with non-heparin anticoagulants.

Hepatectomy

Hepatectomy, also called major hepatectomy, is surgery to remove part of the liver, classically three or more of its eight segments, with mortality now 2 to 3%.

HEPATHER study

ANRS CO22 HEPATHER, a French national prospective observational cohort launched August 2012 (NCT01953458), follows about 21,000 patients with hepatitis B or C to assess real-life treatment effectiveness, safety, and liver disease outcomes.

Hepatic arterial infusion

Hepatic arterial infusion is a regional chemotherapy method that infuses cytotoxic drugs through a catheter in the hepatic artery, mainly for unresectable colorectal liver metastases and cholangiocarcinoma.

Hepatic arteriovenous malformation

A hepatic arteriovenous malformation is a rare vascular malformation in which arteries connect directly to veins in the liver, causing heart failure, portal hypertension, and complications often present from birth.

Hepatic artery aneurysm

Hepatic artery aneurysm (HAA), true or pseudoaneurysm of the hepatic artery; about 20% of splanchnic aneurysms, incidence 0.002%-0.4%, 25% rupture risk, treated first by endovascular repair.

Hepatic artery embolization

Hepatic artery embolization, also called bland transarterial embolization, is an interventional radiology procedure that blocks arterial blood flow to kill liver tumors that cannot be surgically removed.

Hepatic cystic hamartoma

Hepatic cystic hamartoma, also called mesenchymal hamartoma of the liver, is a rare benign multicystic liver tumor of children under 2, treated by complete resection, with rare sarcomatous transformation.

Hepatic encephalopathy

Hepatic encephalopathy (HE), also called portosystemic encephalopathy, is a reversible neuropsychiatric syndrome of liver dysfunction graded by West Haven criteria, treated with lactulose and rifaximin.

Hepatic fibrosis or cirrhosis

Hepatic fibrosis is the buildup of scar tissue in the liver from chronic injury, and cirrhosis is its advanced stage, marked by regenerative nodules and fibrotic septa.

Hepatic haemorrhage

Hepatic hemorrhage is bleeding from the liver tissue or its vessels, most often caused by hepatocellular carcinoma. The spontaneous form is an acute surgical emergency.

Hepatic lipase

Hepatic lipase (HL, LIPC, EC 3.1.1.3) is a hepatocyte-synthesized, heparan-sulfate-bound vascular lipase hydrolyzing triglycerides and phospholipids in IDL, LDL, HDL, and remnants, distinct from pancreatic and lipoprotein lipase.

Hepatic oval stem cell

Hepatic oval stem cells, also called hepatic progenitor or oval cells, are facultative bipotent liver cells with oval nuclei, activated in the canals of Hering when hepatocyte proliferation is impaired during chronic injury.

Hepatic portal system

Hepatic portal system (portal venous system): veins draining the stomach, intestines, pancreas, spleen, and gallbladder into the hepatic portal vein, which supplies about 75% of liver blood flow before blood returns to the inferior vena cava.

Hepatic stellate cell

Hepatic stellate cell (Ito cell, fat-storing cell, lipocyte), a perisinusoidal liver pericyte in the space of Disse storing 50-80% of body vitamin A; activates into collagen-producing myofibroblasts driving liver fibrosis.

Hepatic veno-occlusive disease

Hepatic veno-occlusive disease, or sinusoidal obstruction syndrome (SOS/VOD), is toxic sinusoidal endothelial injury causing nonthrombotic hepatic venular occlusion, mainly after HSCT conditioning or pyrrolizidine alkaloids, treated with defibrotide.

Hepaticogastrostomy

Hepaticogastrostomy is a procedure creating a connection between an intrahepatic bile duct and the stomach, usually performed endoscopically under ultrasound guidance to drain bile when ERCP fails, most often in malignant biliary obstruction.