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Hexafluorenium
Hexafluorenium (Mylaxen), C36H42N2, a bis-quaternary fluorene nondepolarizing neuromuscular blocker and reversible non-competitive plasma cholinesterase inhibitor used to prolong succinylcholine; US NDA withdrawn 1994.
Hexagonaria
Hexagonaria, extinct Devonian colonial rugose coral genus (family Disphyllidae) with honeycomb cerioid corallites; H. percarinatum of Michigan's Gravel Point Formation is the Petoskey stone; went extinct at end-Permian.
Hexamidine
Hexamidine is an aromatic diamidine antiseptic (C20H26N4O2), used as its diisethionate salt for skin infections, amoebic keratitis, and as a preservative, limited to 0.1% in cosmetics.
Hexapoda
Hexapoda is a subphylum of six-legged arthropods comprising the insects and the wingless springtails, coneheads, and two-pronged bristletails. With over one million described species, it is the largest group in the phylum Arthropoda.
HEXASIIL
HEXASIIL (SIIHEXA) is a WHO-prequalified, fully liquid hexavalent DTwP-HepB-IPV-Hib infant vaccine by Serum Institute of India, given at 6, 10, 14 weeks plus a 12-24 month booster.
Hexasodium phytate
Hexasodium phytate (SNF472, hexasodium fytate), intravenous hexasodium salt of phytate (IP6) that binds hydroxyapatite to inhibit vascular calcification and calciphylaxis; tested through phase 3 in hemodialysis patients.
Hexasterophora
Hexasterophora (Schulze, 1886) is the larger subclass of glass sponges (Hexactinellida), defined by hexaster microscleres; sister to Amphidiscophora, with orders Lyssacinosida, Sceptrulophora, and Lychniscosida.
Hexathelid and related tunnel-web spiders of Australasia
Australasian tunnel-web spiders: Australian funnel-web spiders (Atracidae: Atrax, Hadronyche, Illawarra), slender funnel-webs (Hexathelidae), and NZ tunnelwebs (Porrhothelidae); 2018 phylogenomic split of Hexathelidae, δ-hexatoxin venom, and 1981 antivenom.
Hexaxim
Hexaxim (also Hexyon, Hexacima) is Sanofi Pasteur's fully liquid 6-in-1 hexavalent infant vaccine against diphtheria, tetanus, acellular pertussis, polio, hepatitis B, and Hib; WHO-prequalified since December 2014, first licensed 2012, sold in over 100 countries.
Hexazinone
Hexazinone (Velpar, CAS 51235-04-2) is a triazine-dione herbicide, first US-registered in 1975, inhibiting photosynthesis; used on alfalfa, sugarcane, blueberries, and forestry, mobile in soil, low acute toxicity, eye irritant.
Hexestrol
Hexestrol (hexoestrol, CAS 84-16-2) is a synthetic non-steroidal estrogen, a hydrogenated diethylstilbestrol derivative used as a hormonal antineoplastic agent, carcinogenic in hamsters and a Lassa virus entry inhibitor.
Hexetidine
Hexetidine (Oraldene, Hexoral) is a cationic pyrimidine-derivative antiseptic mouthwash for gingivitis, ulcers, sore throat, and thrush; less effective than chlorhexidine, with limited oral retention.
HEXIM1
HEXIM1 (EDG1, CLP-1), hexamethylene bis-acetamide inducible protein 1, is a 359-residue RNA-binding protein that binds 7SK snRNA as a dimer and inhibits the CDK9 kinase of P-TEFb in the 7SK snRNP, regulating transcriptional elongation, HIV Tat competition, and cancer-related gene expression.
Hexobarbital
Hexobarbital, also called hexobarbitone and marketed as Evipan or Evipal, is a short-acting barbiturate anesthetic introduced in 1932 by Bayer chemists, used in over 10 million operations before being replaced by thiopental.
Hexocyclium
Hexocyclium (Tral) is a discontinued quaternary amine muscarinic acetylcholine receptor antagonist, methylsulfate salt, ATC A03AB10, formerly used for gastric ulcers and diarrhea, with about 5-fold ileal over cardiac receptor selectivity.
Hexokinase
Hexokinase (EC 2.7.1.1), also called glucokinase in its HK IV form, is the enzyme that phosphorylates glucose to glucose 6-phosphate with ATP, the first step of glycolysis; vertebrates have isozymes HK I-IV plus HKDC1, and HK2 is overexpressed in many tumors.
Hexosaminidase (β-N-acetylhexosaminidase)
β-N-acetylhexosaminidase (Hex A αβ, Hex B ββ, Hex S αα; HEXA/HEXB) is a lysosomal GH20 enzyme; only Hex A with GM2 activator degrades GM2 ganglioside, and its deficiency causes Tay-Sachs and Sandhoff diseases.
Hexylcaine
Hexylcaine (cyclaine, osmocaine; CAS 532-77-4) is a short-acting ester local anesthetic, 1-(cyclohexylamino)propan-2-yl benzoate, acting on voltage-gated sodium channels; synthesized 1944, used topically from 1952, now discontinued in the US.
Hexythiazox
Hexythiazox (Nissorun) is a non-systemic thiazolidinone acaricide, IRAC Group 10A mite growth inhibitor, developed by Nippon Soda and marketed from 1985; ovicidal against phytophagous mites, targeting chitin synthase-1, with EU approval to 2027.
HEY1
HEY1 (HESR1, HERP2, HRT-1) is a human bHLH-Orange transcriptional repressor gene, a direct Notch target that also corepresses the androgen receptor, drives vascular development with HEY2, and is a prognostic marker in glioblastoma.
Heyde's syndrome
Heyde's syndrome is the triad of aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome caused by shear-induced loss of high-molecular-weight vWF multimers; aortic valve replacement resolves most cases.
Heymut Omran
Heymut Omran, born 1967 in Castrop-Rauxel, Germany, is a German pediatric pulmonologist and cilia researcher at University Hospital Münster known for identifying genes that cause primary ciliary dyskinesia.
HFB1011 (anti-CCR8 antibody)
HFB1011 (HFB101110) is HiFiBiO Therapeutics' humanized anti-CCR8 monoclonal antibody that depletes tumor-infiltrating regulatory T cells via ADCC and blocks CCL1 binding; licensed to FibroGen in 2021, returned to HiFiBiO in 2025.
Hfq protein
Hfq, or host factor for phage Qβ, is a conserved bacterial RNA-binding protein that helps small regulatory RNAs base-pair with target messenger RNAs, shaping gene expression.
Hg(II)-responsive transcriptional regulator
Hg(II)-responsive transcriptional regulator, archetype MerR of the MerR family: bacterial homodimeric DNA-binding protein that activates mercury resistance (merTPAD) operons on Hg(II) binding by distorting suboptimally spaced promoters; used in heavy metal biosensors.
HGC-27
HGC-27 (CVCL_1279, ECACC 94042256) is a human gastric cancer cell line established in 1976 from a metastatic lymph node of a Japanese patient with undifferentiated carcinoma; mucin-producing, adherent, TP53/PIK3CA-mutant, highly invasive.
HGH Fragment 176–191
HGH Fragment 176-191 (hGH 176-191, Frag 176-191) is the synthetic 16-amino-acid C-terminal fragment of human growth hormone, sequence FLRIVQCRSVEGSCGF, studied for lipolytic activity; distinct from AOD-9604, with no human trials and no regulatory approval.
HGS
HGS (Hrs, Vps27, ZFYVE8), hepatocyte growth factor-regulated tyrosine kinase substrate at 17q25.3, encodes the 777-aa ESCRT-0 core protein that sorts ubiquitinated receptors into multivesicular bodies for lysosomal degradation.
Hh blood group
Hh blood group (ISBT H, 018): system based on the H antigen made by FUT1 and FUT2. Homozygous hh gives the rare Bombay (Oh) phenotype, anti-H, transfusable only with Bombay blood; para-Bombay is the weak-H variant.
HH2853 (EZH1/2 inhibitor)
HH2853 (HH 2853, HH-2853) is an oral dual EZH1/EZH2 inhibitor from Haihe Biopharma that blocks H3K27 methylation; phase I/II trials show responses in PTCL and epithelioid sarcoma.