(Ca²⁺) trial
The (Ca²⁺) trial, NCT07570342, is a not-yet-recruiting ART Fertility Clinics trial comparing ionomycin versus CultActive calcium ionophore, with and without CaCl2, for assisted oocyte activation in ICSI fertilization failure.
(CBT) study
(CBT) study: the PanicDoc open-label randomized controlled trial of app-based CBT for panic disorder versus guided psychoeducation; 52 patients, PDSS improvement (LSMD −3.71), 80.8% completion, no serious adverse events.
[CRMRF] trial
The [CRMRF] trial (NCT05844189) tested 448 kHz capacitive resistive monopolar radiofrequency plus Thiele massage versus manual therapy alone in 44 women aged 18-30 with superficial dyspareunia; both groups improved, with modest added CRMRF benefit.
[MMD] trial
The [MMD] trial (NCT03438370) was a cluster-randomized non-inferiority trial in Lesotho, sponsored by Equip Lesotho, testing community-based multi-month dispensing of ART; 5,336 stable adults showed retention and viral suppression non-inferior to facility care.
@neurIST study
@neurIST study: data collection program of @neurIST (Integrated Biomedical Informatics for the Management of Cerebral Aneurysms), a 2006-2010 EU FP6 project; 28 institutions, 12 countries, €17.1M; over 1400 aneurysm patients; continued as NCT05526352 registry.
*BFR* trial (NCT07406763)
The BFR trial (NCT07406763) is a completed double-blinded Egyptian randomized controlled trial, acronym BFR, testing blood flow restriction added to traditional rehabilitation after ACL reconstruction with semitendinosus autograft in 36 adults aged 18-35, measuring strength, proprioception, ROM, pain, and function.
10-2 visual field testing
10-2 visual field testing is an automated perimetry program measuring light sensitivity across the central 10° of vision, used to detect and monitor glaucoma and hydroxychloroquine retinopathy.
10–20 system
The 10–20 system is the international standard method for placing EEG electrodes on the human scalp, defining positions as percentages of distances between four skull landmarks; it was published by Herbert H. Jasper in 1958.
1000Plus study
1000Plus (NCT00715533) was a prospective single-center observational study at Charité Berlin testing the DWI-perfusion mismatch concept in acute stroke and TIA patients within 24 hours of onset, using 3T stroke MRI, with infarct growth as the primary endpoint.
108 Military Central Hospital
108 Military Central Hospital (Bệnh viện Trung ương Quân đội 108), founded April 1, 1951 in Thai Nguyen, is a Hanoi-based special-grade military hospital under Vietnam's Ministry of National Defence, twice named Hero of the People's Armed Forces and a pioneer in Vietnamese transplant surgery.
1206 study
The 1206 study (NCT06282237) is an Italian prospective observational study of soft tissue sarcoma surgery patients, assessing rehabilitation effects on motor performance and quality of life using TESS, gait analysis, and pain and QoL questionnaires.
12q14 microdeletion syndrome
12q14 microdeletion syndrome (del(12)(q14), osteopoikilosis-short stature-intellectual disability syndrome) is a rare contiguous-gene deletion disorder with failure to thrive, short stature from HMGA2 haploinsufficiency, osteopoikilosis from LEMD3 loss, and SRS-like features.
13q12.3 microdeletion syndrome
13q12.3 microdeletion syndrome (Del(13)(q12.3), monosomy 13q12.3) is a rare chromosomal anomaly with moderate intellectual disability, speech delay, postnatal microcephaly, atopic dermatitis, characteristic facies, and reduced pain sensitivity, attributed mainly to HMGB1 haploinsufficiency.
14q11.2 microduplication syndrome
14q11.2 microduplication syndrome (Dup(14)(q11.2), trisomy 14q11.2) is an ultrarare chromosomal anomaly, under 1 per million, causing developmental delay, intellectual disability with speech impairment, and epilepsy; the 35 kb critical region contains CHD8 and SUPT16H.
1518 smallpox epidemic in the Caribbean
The 1518 smallpox epidemic in the Caribbean was the first documented smallpox outbreak in the Americas, beginning on Hispaniola in December 1518 and killing an estimated third to half of the indigenous population.
1562 Bahia smallpox epidemic
The 1562 Bahia smallpox epidemic was the first great smallpox outbreak recorded in colonial Brazil, killing tens of thousands of Indigenous people along the Bahian coast in 1562 and 1563.
15q overgrowth syndrome
15q overgrowth syndrome (ORPHA:314585, OMIM 614846) is a rare partial trisomy/tetrasomy of distal chromosome 15q, often involving IGF1R, causing overgrowth, characteristic facies, renal anomalies, and learning difficulties.
15q11.2 microdeletion syndrome
15q11.2 microdeletion syndrome, or Burnside–Butler syndrome, is a rare genomic disorder from a deletion on chromosome 15, increasing risk of developmental delay, autism, and epilepsy.
15q11q13 microduplication syndrome
15q11q13 microduplication syndrome (dup15q, idic(15)) is a neurodevelopmental disorder from extra maternally inherited copies of 15q11.2-q13.1, causing hypotonia, intellectual disability, ASD, language delay, and epilepsy; paternal duplications are usually mild or silent.
15q13.3 microdeletion syndrome
15q13.3 microdeletion syndrome (Del(15)(q13.3), OMIM 612001) is a rare recurrent BP4-BP5 chromosome 15 deletion involving CHRNA7 and OTUD7A, causing variable developmental delay, epilepsy, autism, and schizophrenia risk with incomplete penetrance.
16p13.11 microdeletion syndrome
16p13.11 microdeletion syndrome, also called Del(16)(p13.11), is a rare recurrent copy-number loss on chromosome 16p13.11 causing developmental delay, microcephaly, epilepsy, short stature, and dysmorphism, with incomplete penetrance and NDE1 and MYH11 as key genes.
16p13.11 microduplication syndrome
16p13.11 microduplication syndrome (Dup(16)(p13.11), trisomy 16p13.11) is a rare recurrent chromosome 16p13.11 copy number gain causing variable developmental, behavioral, cardiac, and skeletal features with incomplete penetrance.
16p13.3 microduplication syndrome
16p13.3 microduplication syndrome, also called distal duplication 16p or dup(16)(p13.3), is a rare chromosomal disorder from extra copy of CREBBP at 16p13.3, causing intellectual disability, speech delay, proximally implanted thumbs, and characteristic facies, reciprocal to Rubinstein–Taybi syndrome.
16q24.3 microdeletion syndrome
16q24.3 microdeletion syndrome, also called monosomy 16q24.3 or Del(16)(q24.3), is a very rare chromosomal deletion disorder overlapping KBG syndrome, caused by de novo 16q24.3 deletions involving ANKRD11, with developmental delay, facial dysmorphism, seizures, and autism spectrum disorder.
1713 Cape smallpox epidemic
The 1713 Cape smallpox epidemic reached the Dutch East India Company's Cape station in February 1713, apparently via contaminated ship linen, killing a quarter of the colonists and devastating the Khoikhoi.
1775–1782 North American smallpox epidemic
The 1775–1782 North American smallpox epidemic was a continent-wide outbreak coinciding with the Revolutionary War that killed more than 130,000 people across Canada, the United States, and Mexico.
17p11.2 microduplication syndrome
17p11.2 microduplication syndrome, or Potocki-Lupski syndrome (PTLS), a rare autosomal dominant chromosomal disorder from duplication of 17p11.2 including RAI1, reciprocal to Smith-Magenis deletion, causing hypotonia, developmental delay, heart defects, and sleep apnea.
17p13.3 microduplication syndrome
17p13.3 microduplication syndrome (17p13.3 duplication syndrome, Dup(17)(p13.3), trisomy 17p13.3) is a rare genomic disorder with psychomotor delay, dysmorphic features, and autism, divided into class I (YWHAE) and class II (PAFAH1B1/LIS1) duplications.
17q11.2 microduplication syndrome
17q11.2 microduplication syndrome (NF1 microduplication, Grisart-Destrée syndrome) is an ultra-rare autosomal dominant chromosome 17q11.2 duplication causing intellectual disability, dysmorphism, and seizures, with incomplete penetrance and no neurofibromas.
17q12 microduplication syndrome
17q12 microduplication syndrome (17q12 duplication, trisomy 17q12, OMIM 614526) is a rare autosomal dominant chromosomal disorder from a recurrent 1.4 Mb duplication at 17q12, causing variable developmental delay, intellectual disability, seizures, microcephaly, and reduced penetrance.