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All articles starting with M

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Methylammonium lead bromide

Methylammonium lead bromide (MAPbBr3, CH3NH3PbBr3) is a hybrid organic–inorganic halide perovskite first synthesized by Dieter Weber in 1978 and studied for LEDs, lasers, and X-ray detectors.

Methylammonium lead iodide

Methylammonium lead iodide (CH₃NH₃PbI₃, commonly abbreviated MAPbI₃) is a hybrid organic–inorganic perovskite semiconductor that debuted in solar cells at 3.8% efficiency in 2009 and became the most studied perovskite light absorber.

Methylammonium tin iodide (MASnI3)

Methylammonium tin iodide, or MASnI3, is a lead-free tin perovskite semiconductor with a bandgap near 1.3 eV, first used in a solar cell in 2014, with best efficiency near 8%.

Methylated DNA immunoprecipitation

Methylated DNA immunoprecipitation (MeDIP) is an antibody-based method that enriches methylated DNA fragments for methylation analysis, first reported in Nature Genetics in 2005 and widely used with sequencing as MeDIP-seq.

Methylated DNA immunoprecipitation sequencing

Methylated DNA immunoprecipitation sequencing, known as MeDIP-Seq, is an epigenomic method reported in 2008 that enriches methylated DNA fragments with an antibody and sequences them to map DNA methylation across a genome.

Methylated RNA immunoprecipitation sequencing

Methylated RNA immunoprecipitation sequencing, also called MeRIP-seq or m6A-seq, is an antibody-based method that maps N6-methyladenosine across the transcriptome by high-throughput sequencing, reporting methylated regions roughly 100 to 200 nucleotides wide rather than single sites.

Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding

Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding (IPR014048, PF01035) is the C-terminal helix-turn-helix DNA-binding domain of AGT/MGMT/OGT, the suicide DNA repair enzyme that removes O6-alkyl groups from guanine via Cys145.

Methylation

Methylation: addition of a methyl group, in biology catalyzed by SAM-dependent methyltransferases acting on DNA (5mC), RNA (m6A, m5C), histones, and proteins; basis of epigenetics and target of azacitidine, decitabine.

Methylation sequencing

Methylation sequencing determines which cytosines in a genome carry a methyl mark, typically by bisulfite conversion before sequencing, and reports per-cytosine methylation fractions at single-base resolution genome-wide.

Methylation-sensitive restriction enzyme sequencing

Methylation-sensitive restriction enzyme sequencing (MRE-seq) is a DNA methylation profiling method that digests DNA with enzymes cutting only unmethylated CpG sites, mapping methylation genome-wide from read coverage without bisulfite conversion.

Methylation-specific PCR

Methylation-specific PCR (MSP) is a bisulfite-conversion PCR assay that detects methylated alleles at CpG island loci, introduced in 1996 and the most common clinical technique for detecting aberrant DNA methylation.

Methylcobalamin

Methylcobalamin (mecobalamin, MeCbl) is one of the two active coenzyme forms of vitamin B12, serving as the cofactor for the enzyme methionine synthase and sold as a supplement.

Methylcyclohexane

Methylcyclohexane, also called hexahydrotoluene, is a cycloalkane produced by hydrogenating toluene; it stores hydrogen for shipment in ordinary fuel infrastructure and released 210 tons delivered from Brunei to Japan in 2020.

Methylcyclopentane

Methylcyclopentane is a cycloalkane with the formula C₆H₁₂, a colorless, water-insoluble liquid boiling at 71.8 °C that occurs in petroleum and serves as a gasoline component and solvent.

Methyldopa

Methyldopa (alpha-methyldopa, Aldomet) is a centrally acting antihypertensive prodrug converted to alpha-methylnorepinephrine, an alpha-2 agonist. Developed in the 1950s, now used mainly for hypertension in pregnancy; causes sedation and depression.

Methylene (compound)

Methylene, also known as the methylene radical, is the simplest carbene, a reactive CH₂ molecule with a divalent carbon bearing two nonbonding electrons, generated from diazomethane.

Methylene blue

Methylene blue, a phenothiazine dye synthesized by Caro in 1876, is the standard antidote for methemoglobinemia (1 mg/kg IV), a stain, and an investigational NO-cGMP inhibitor in vasodilatory shock with unproven mortality benefit.

Methylene diphenyl diisocyanate

Methylene diphenyl diisocyanate (MDI) is an aromatic diisocyanate, mainly the 4,4'-isomer, produced industrially as polymeric PMDI, that reacts with polyols to form rigid polyurethane insulation foams.

Methylenebisthiocyanate

Methylenebisthiocyanate (MBT, methylene dithiocyanate, CAS 6317-18-6) is an organosulfur biocide used against slime-forming bacteria, fungi, and algae in cooling water, paper mills, and wood treatment; first US-registered 1949, not EU-approved for product-type 12.

Methylenedioxypyrovalerone

Methylenedioxypyrovalerone (MDPV) is a pyrrolidinophenone synthetic cathinone stimulant from bath salts; a potent DAT/NET uptake blocker, more reinforcing than cocaine in animals, Schedule II internationally.

Methylenetetrahydrofolate reductase

Methylenetetrahydrofolate reductase, or MTHFR, is a cytoplasmic enzyme encoded on chromosome 1 that produces 5-methyltetrahydrofolate, used to remethylate homocysteine to methionine; rare variants cause homocystinuria.

Methylenetetrahydrofolate reductase deficiency

MTHFR deficiency, or homocystinuria due to N(5,10)-methylenetetrahydrofolate reductase deficiency, is an autosomal recessive remethylation disorder causing high homocysteine with low methionine; betaine given early reduces mortality and improves neurodevelopment.

Methylergometrine

Methylergometrine (methylergonovine, Methergine) is a semisynthetic ergot alkaloid uterotonic, 0.2 mg IM/IV, used for postpartum uterine atony and hemorrhage; WHO no longer recommends it for PPH prevention because it raises blood pressure.

Methylethyl ketone oxime

Methylethyl ketone oxime, also known as butanone oxime or MEKO, is a colorless volatile liquid used as an anti-skinning agent in alkyd paints and coatings.

Methylglyoxal

Methylglyoxal, also known as pyruvic aldehyde, is a highly reactive three-carbon ketoaldehyde formed as a glycolysis byproduct and in food browning, studied for links to diabetes and aging.

Methylglyoxal synthase

Methylglyoxal synthase (MGS, EC 4.2.3.3, gene mgsA) is a bacterial homohexameric enzyme converting dihydroxyacetone phosphate to methylglyoxal and phosphate in the glycolytic methylglyoxal bypass, allosterically inhibited by phosphate and structurally unrelated to triosephosphate isomerase.

Methylhexanamine

Methylhexanamine, better known as DMAA (dimethylamylamine), is a synthetic stimulant patented in 1944 as the nasal decongestant Forthane and later sold in supplements, which the FDA now considers illegal.

Methylhomatropine

Methylhomatropine, sold as homatropine methylbromide (CAS 80-49-9), is a quaternary ammonium muscarinic antagonist derived from homatropine, used in antacid antispasmodic combinations and formerly with hydrocodone in Hycodan.

Methylisothiazolinone

Methylisothiazolinone (MI, MIT, 2-methyl-4-isothiazolin-3-one), a preservative used with MCI as Kathon and alone in cosmetics since 2005, caused an epidemic of allergic contact dermatitis and was 2013 Allergen of the Year.

Methylmalonic acid

Methylmalonic acid is a dicarboxylic acid intermediate in the metabolism of certain amino acids and odd-chain fatty acids, and a biomarker of vitamin B12 deficiency.