All articles starting with P

PRKCB

PRKCB (PKCβ, protein kinase C beta, HGNC:9395) is a human chromosome 16 gene encoding a calcium- and diacylglycerol-dependent kinase with Beta-I and Beta-II splice isoforms, essential for B-cell NF-kappa-B signaling and studied as a drug target in diabetic complications and cancer.

PRKCD

PRKCD (protein kinase C delta, PKCδ, HGNC:9399) is a human gene at 3p21.1 encoding a 676-aa, diacylglycerol-activated, calcium-independent PKC kinase regulating apoptosis and cell cycle; biallelic loss-of-function mutations cause ALPS type III with SLE-like autoimmunity.

PRKCG

PRKCG is a human gene on chromosome 19 encoding PKCγ, a kinase in neurons that mediates synaptic plasticity and causes spinocerebellar ataxia type 14 when mutated.

PRKCI

PRKCI (protein kinase C iota, PKCι; mouse homolog PKCλ) is a human gene at 3q26.2 encoding an atypical PKC serine/threonine kinase, a bona fide oncogene amplified in cervical, head and neck, lung squamous, and ovarian cancers.

PRKCQ

PRKCQ encodes PKCθ (protein kinase C theta), a Ca2+-independent novel PKC kinase enriched in T cells, recruited to the immunological synapse to activate NF-κB, AP-1, and NFAT, and a selective immunosuppression drug target.

PRKCSH

PRKCSH (hepatocystin, 80K-H) is a human gene on 19p13.2 encoding the beta subunit of ER glucosidase II; mutations cause autosomal dominant polycystic liver disease via a two-hit loss of polycystin-1.

PRKCZ

PRKCZ (protein kinase C zeta, HGNC:9412, Gene ID 5590) is a human 1p36 gene encoding atypical PKCζ, a Ca2+/DAG-independent kinase, plus the PKMζ memory isoform; knockout mice are viable.

PRKD1

PRKD1, also called PKCµ or PKD1, is a human gene at chromosome 14q12 encoding protein kinase D1, a serine/threonine kinase involved in Golgi trafficking, cell migration, and survival.

PRKDC

PRKDC (XRCC7, HYRC1) is a human gene at 8q11.21 encoding DNA-PKcs, the PIKK-family catalytic subunit of DNA-dependent protein kinase. It drives NHEJ double-strand break repair and V(D)J recombination; biallelic variants cause autosomal recessive SCID (IMD26), and DNA-PK inhibitors are in cancer trials.

PRKG1

PRKG1 (protein kinase cGMP-dependent 1, PKG-1/cGKI) is a human chromosome 10 gene encoding soluble cGMP-dependent protein kinase isoforms Iα and Iβ, key NO/cGMP signaling mediators in smooth muscle and platelets; the gain-of-function R177Q variant causes heritable thoracic aortic aneurysm and dissection.

PRKN

PRKN (PARK2) is the human gene encoding parkin, an RBR E3 ubiquitin ligase that with PINK1 drives mitophagy; biallelic variants cause autosomal recessive early-onset Parkinson disease (PARK-Parkin), median onset 31 years.

Sep 19, 2026

Prljavo Kazalište

Prljavo Kazalište, Croatian for "Dirty Theatre," is a rock band from Zagreb formed in 1977, a leading act of the Yugoslav new wave that became a mainstream rock institution.

PRM800K

PRM800K is an OpenAI dataset released in May 2023 with 800,000 human step-level correctness labels for model-generated solutions to MATH problems, the reference dataset for training process reward models.

PRMT1

PRMT1 (protein arginine methyltransferase 1, Gene ID 3276) is the major type I human arginine methyltransferase, producing about 85% of type I PRMT activity, methylating RGG/RG motifs and H4R3, and acting as an oncogenic target with clinical inhibitors in trials.

PRMT5

PRMT5 (protein arginine methyltransferase 5) is a type II methyltransferase catalyzing symmetric arginine dimethylation; overexpressed in many cancers and targeted by SAM-competitive, substrate-competitive, and MTA-cooperative inhibitors in clinical trials.

Oct 22, 2026

pRNA nanoparticles

pRNA nanoparticles are nanostructures built from packaging RNA of the bacteriophage phi29 DNA packaging motor, engineered to deliver siRNA and other therapeutics to targeted cells.

Oct 15, 2026

PRNET

PRNET, the Packet Radio Network, was an experimental wireless packet-switched network funded by DARPA from 1973, connecting mobile computers over broadcast radio as one of the early Internet's three original networks.

Pro bono

Pro bono (from Latin pro bono publico, for the public good) is voluntary, unpaid professional work, chiefly free legal services. Distinguished by ABA Model Rule 6.1's 50-hour aspiration, 2013 ABA Standards, and mandatory California reporting from 2026.

Pro Bono (프로보노)

Pro Bono (프로보노) is a 2025-2026 tvN Korean courtroom drama starring Jung Kyung-ho as disgraced judge Kang Da-wit, who joins a mega law firm's zero-revenue public-interest team; written by Moon Yu-seok, directed by Kim Sung-yoon, ending at 10.0% Nielsen.

Pro Bowl

Pro Bowl: the NFL's annual all-star honor since 1939, long an AFC-NFC exhibition game, rebranded 2023 as the Pro Bowl Games (skills events plus flag football), and from 2026 an 88-player selection with no game.

Pro c 5

Pro c 5 is the WHO/IUIS-designated myosin light chain 1 allergen, 18 kDa, of the red swamp crayfish Procambarus clarkii, a food allergen with unclear clinical relevance; isoallergen Pro c 5.0101 (UniProt J7HCX7).

Pro Display XDR

Pro Display XDR is a 32-inch 6K professional reference display by Apple, introduced in 2019 and discontinued in 2026 in favor of the Studio Display XDR.

Pro Era

Pro Era (Progressive Era) is a Brooklyn hip-hop collective founded in 2011 by Joey Bada$$, Capital STEEZ, and Powers Pleasant, known for 1990s boom-bap revivalism, the 2012 mixtape PEEP: The aPROcalypse, and the Beast Coast supergroup.

Pro Evolution Soccer

Pro Evolution Soccer, also known as Winning Eleven, was Konami's association football game series released annually from 2001 to 2021 and rebranded in 2021 as the free-to-play eFootball.

Pro Evolution Soccer 2016

Pro Evolution Soccer 2016 (Winning Eleven 2016 in Japan) is Konami's 20th anniversary football simulation, released September-October 2015 on PS4, PS3, Xbox One, Xbox 360 and PC, with UEFA Champions League exclusivity, dynamic weather and strong reviews.

Pro Evolution Soccer 2017

Pro Evolution Soccer 2017 (Winning Eleven 2017) is Konami's football simulation released September 2016 on PS4, PS3, Xbox One, Xbox 360, PC, and mobile, known for Real Touch, Adaptive AI, and a Metacritic 85.

Pro Evolution Soccer 2018

Pro Evolution Soccer 2018 (PES 2018), Konami's 22nd soccer sim, released 14 September 2017 on PS4, PS3, Xbox One, Xbox 360, PC and later mobile; features Strategic Dribbling, Real Touch+, slower pacing, and limited licenses.

Pro Evolution Soccer 2019

Pro Evolution Soccer 2019 (PES 2019) is Konami's football simulation released August 30, 2018 for PS4, Xbox One, and PC Steam, with 11 new skill traits, Visible Fatigue, a revamped myClub, and ICC-licensed Master League.

Pro Evolution Soccer 3

Pro Evolution Soccer 3 (Winning Eleven 7) is Konami's 2003 soccer simulation for PS2 and PC, its first PC release, with a new engine, FIFPro players, Master League, and over 1 million copies sold in Japan and Europe.