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Spinal pain
Spinal pain is discomfort in the back arising from spinal muscles, nerves, bones, or joints. Low back pain, its most common form, is the leading cause of disability worldwide.
Spinal stenosis
Spinal stenosis, narrowing of the spinal canal or nerve root spaces pressing on the spinal cord and nerves; most common in the lumbar and cervical spine, caused mainly by aging, with leg symptoms eased by flexion.
Spinal Tap (band)
Spinal Tap (Spin̈al Tap) is a fictional English heavy metal band created by Christopher Guest, Michael McKean, Harry Shearer, and Rob Reiner in 1978, made famous by the 1984 mockumentary This Is Spinal Tap and its 2025 sequel; the actors really tour and record under the name.
Spinal Tap II: The End Continues
Spinal Tap II: The End Continues is a 2025 mockumentary comedy sequel to This Is Spinal Tap, directed by Rob Reiner, reuniting McKean, Guest, and Shearer for one final New Orleans concert, with McCartney and Elton John cameos.
Spinalonga (Σπιναλόγκα)
Spinalonga (Σπιναλόγκα), also Kalydon or "spina lunga", is a fortified islet in Elounda harbour, Crete: Venetian bastion fortress 1579-1715, Ottoman town to 1897, Greek leper colony 1903-1957, now an archaeological site.
SPINALSTIM trial
SPINALSTIM (NCT07237165) is a randomized, double-blind French trial sponsored by CHU Grenoble Alpes testing trans-spinal and ganglionic direct current stimulation against sham for chronic pelvic pain in 60 patients.
Spinario
Spinario, also called the Boy with Thorn, is a 1st-century-BC bronze statue of a boy pulling a thorn from his foot, in Rome's Capitoline Museums.
SpinChip Diagnostics
SpinChip Diagnostics is a Norwegian point-of-care in vitro diagnostics company based in Oslo, founded in 2012 as a SINTEF spin-off and agreed in 2025 to be acquired by bioMérieux.
Spinderella
Spinderella is a 2015 Zoch Verlag children's board game by Roberto Fraga and Doris Matthäus for 2-4 players ages 6+, in which magnetic spiders on a web catch racing ants; it won Kinderspiel des Jahres 2015.
Spindle (textiles)
Spindle (textiles): a shaft with a whorl for hand-spinning fiber into yarn; drop and supported types; used since the Neolithic, replaced by the spinning wheel in the late Middle Ages.
Spindle and kinetochore-associated protein 1
SKA1 (C18orf24), spindle and kinetochore-associated complex subunit 1, is a 255-amino-acid human protein of the SKA1-SKA2-SKA3 complex that stabilizes kinetochore-microtubule attachments in mitosis and, when overexpressed, drives metastasis and cisplatin resistance in lung and other cancers.
Spindle apparatus
Spindle apparatus (mitotic spindle): microtubule structure of cell division with two spindle poles and astral, polar, and kinetochore microtubules; segregates chromosomes, targeted by taxanes and vinca alkaloids.
Spindle assembly checkpoint component Mad1
Mad1 (MAD1L1), mitotic arrest deficient 1, is a coiled-coil spindle assembly checkpoint scaffold that recruits Mad2 to unattached kinetochores as a 2:2 MAD1:C-MAD2 tetramer catalyzing Mad2's open-to-closed conversion; MPS1-regulated, also recruits CENP-E, and dosage changes cause aneuploidy and cancer.
Spindle cell hemangioma
Spindle cell hemangioma, also called spindle cell hemangioendothelioma, is a rare benign vascular tumor of the dermis and subcutis with IDH1/IDH2 mutations, painful limb nodules, frequent local recurrence, and no metastatic potential.
Spindle orientation and cleavage-plane specification
Spindle orientation and cleavage-plane specification: how dividing cells position the mitotic spindle via astral microtubules, cortical dynein, and the conserved Gαi–LGN–NuMA complex to set the cleavage plane, daughter-cell size, and fate.
Spindle-shaped archaeal viruses
Spindle-shaped archaeal viruses are viruses of archaea with lemon- or spindle-shaped virions, a morphotype exclusive to the Archaea, infecting hosts from hot springs to salt lakes.
SpindleHorse
SpindleHorse (SpindleHorse Toons) is the independent, women-led Burbank, California animation studio founded in 2018 by Vivienne Medrano (VivziePop), producer of Hazbin Hotel and Helluva Boss, unionized with IATSE in 2025.
Spindletop
Spindletop, an oil field south of Beaumont, Texas, marked the birth of the modern petroleum industry when the Lucas Gusher blew in on January 10, 1901.
Spindrift Beverage Co.
Spindrift Beverage Co. is an American beverage company in Newton, Massachusetts, founded by Bill Creelman in 2010, known for sparkling water made with real squeezed fruit.
Spine (video game)
SPINE (SPINE - This is Gun Fu) is an upcoming single-player cyberpunk gun-fu action game by Nekki, starring Redline and her sentient implant in Tensor City, launching Summer 2027 on PC, PS5, and Xbox Series X|S.
Spine deformity
Spine deformity, including scoliosis and adult spinal deformity, is an abnormal spinal curvature measured by the Cobb angle; prevalence reaches 68% over age 60, managed nonoperatively or by fusion.
Spinel
Spinel, also known as Balas ruby, is a magnesium aluminum oxide gem mineral, historically mistaken for ruby; famous "rubies" in the English Crown Jewels are spinel.
Spinetoram
Spinetoram (DIANA), a semisynthetic spinosyn insecticide from Saccharopolyspora spinosa, major component 3′-O-ethyl-5,6-dihydro spinosyn J; launched 2007, Green Chemistry Award 2008, EU approval expired 2024.
SPINK1
SPINK1 (serine peptidase inhibitor Kazal type 1; PSTI, TATI) is a 56-amino-acid trypsin inhibitor secreted by pancreatic acinar cells; loss-of-function variants, notably N34S, raise pancreatitis risk tenfold to 40-fold heterozygously.
SPINK5
SPINK5 (serine peptidase inhibitor Kazal type 5), also called LEKTI/NETS, is a gene on 5q32 encoding a 15-domain serine protease inhibitor; biallelic mutations cause Netherton syndrome, and it acts as a tumor suppressor in oral squamous cell carcinoma.
Spinka (שפינקא) (Hasidic dynasty)
Spinka (שפינקא) is a Hasidic dynasty founded by Rabbi Yosef Meir Weiss in 1876 in Spinka, Maramureș, now Romania, and continued today by dozens of rebbes in the United States and Israel.
SpinLaunch
SpinLaunch is a California-based space company founded in 2014 that uses a large electric centrifuge in a vacuum chamber to launch projectiles, with suborbital test flights from Spaceport America in New Mexico since 2021.
Spinlock
A spinlock is a mutual exclusion lock where a waiting thread busy-waits by repeatedly checking the lock, efficient for critical sections shorter than a context switch.
Spinnaker
A spinnaker is a large, light, three-cornered downwind sail set flying from the masthead on a sailing yacht, in symmetric and asymmetric types, first recorded in 1866.
Spinner (robot)
Spinner is an unmanned ground combat vehicle prototype developed for DARPA by Carnegie Mellon University's NREC with Boeing, known for driving while upside down and serving as the base for its successor, Crusher.