400 articles
11-18
11-18 (II-18, CVCL_6659, RRID:CVCL_6659) is a human lung adenocarcinoma cell line carrying EGFR L858R and TP53 K164 mutations, banked at RIKEN as RCB2093, used in EGFR inhibitor resistance research.
143B
143B (HOS-143B, 143B TK-, ATCC CRL-8303) is a human osteosarcoma cell line derived from HOS by Ki-ras viral transformation; it is thymidine kinase negative, tumorigenic, and highly metastatic to lung in mouse models.
184A1
184A1 (184 A1, H184A1, CVCL_3040, ATCC CRL-8798) is an immortalized, non-malignant human mammary epithelial cell line from a 21-year-old reduction mammoplasty donor, transformed with benzo(a)pyrene; p53/RB wild type, karyotype 45,XX.
184B5
184B5 (184-B5, H184B5; CVCL_4688, ATCC CRL-8799) is an immortalized, non-malignant human mammary epithelial cell line from normal reduction mammoplasty tissue, chemically transformed with benzo[a]pyrene by Stampfer and Bartley (1985), karyotype 47,XX, p53-positive.
253J
253J (253J-P, 253JP) is a human bladder carcinoma cell line from a metastatic retroperitoneal lymph node, established in 1974; parent of metastatic variants 253J-BV and 253J-Lung-IV.
486P
486P (486-P, RRID:CVCL_7940) is a human bladder carcinoma cell line established by Elliott and colleagues in the 1970s, formerly ATCC HTB-7 (discontinued), with a 35-hour doubling time from a 61-year-old male donor.
5637
5637 is a human bladder carcinoma cell line established in 1974 from a 68-year-old man, known for secreting growth factors and widely used in bladder cancer drug-response research.
575A
575A (CVCL_7941, RRID:CVCL_7941) is a human bladder carcinoma cell line from a 59-year-old male donor, doubling time 50 hours, part of the BLA-40 and UBC-40 panels, formerly ATCC HTB-8, used in RXRA S427F and cisplatin studies.
639V
639V (639-V, CVCL_1048, RRID:CVCL_1048) is a human ureter urothelial (transitional cell) carcinoma cell line established in 1973 from a 69-year-old man, distributed by DSMZ as ACC-413, with TP53, KRAS, PTEN, and TERT promoter mutations.
647V
647V (647-V, CVCL_1049) is a human bladder carcinoma cell line from a 59-year-old male, established in 1976, with EP300, TP53, and TERT promoter mutations, doubling time about 30-32 hours.
769-P
769-P (769P, CVCL_1050, ATCC CRL-1933) is a human renal cell adenocarcinoma cell line established in 1975 from a 63-year-old woman; VHL-altered, VEGF-secreting ccRCC model with 35-hour doubling time.
8505C
8505C (CVCL_1054, ECACC 94090184) is a human anaplastic thyroid carcinoma cell line established in 1988 from a 78-year-old woman, carrying homozygous BRAF V600E and TP53 Arg248Gly mutations, used widely in ATC research.
A-204
A-204 (A204, ATCC HTB-82, CVCL_1058) is a human cancer cell line established in 1973 from a 1-year-old girl's rhabdomyosarcoma, later reclassified as a rhabdoid tumor line via its SMARCB1 mutation; used in sarcoma drug screens and TKI resistance studies.
A-253
A-253 (A253, CVCL_1060, ATCC HTB-41) is a human cancer cell line established in 1973 from a submandibular salivary gland carcinoma of a 54-year-old man; epithelial, beta-2 adrenergic receptor positive, PTEN-mutant, tumorigenic in nude mice.
A-375
A-375 (A375, CVCL_0132) is a human melanoma cell line from a 54-year-old female, BRAF V600E homozygous, poorly differentiated and amelanotic; a standard melanoma research and xenograft drug-screening model.
A-388
A-388 (A388; CVCL_1063; ATCC CRL-7905) is a human adherent epithelial cancer cell line from a lymph node metastasis of skin squamous cell carcinoma, established 1973, male donor age 86, with EGFR, PIK3CA, and TP53 mutations.
A-427
A-427 (A427, CVCL_1055, ATCC HTB-53, DSMZ ACC 234) is a human lung adenocarcinoma cancer cell line from a 52-year-old White male, KRAS Gly12Asp and CTNNB1 Thr41Ala mutant, used in CCLE/DepMap and drug screening.
A-431
A-431 (A431, CVCL_0037) is a human epidermoid carcinoma cell line from an 85-year-old female, established by Giard et al. in 1973, famed for ~1.8 million EGFR receptors per cell, EGF-induced growth inhibition, TP53 R273H, and wide use in EGFR and skin cancer research.
A-498
A-498 (A498, CVCL_1056, ATCC HTB-44, DSMZ ACC 55) is a human renal cell carcinoma cell line established in 1973, part of the NCI-60 panel; VHL-null, SETD2-mutant ccRCC model with clear-cytoplasm xenografts.
A-673
A-673 (A673, RMS 1598, CVCL_0080, ATCC CRL-1598) is a human Ewing sarcoma cell line from a 15-year-old girl, once misclassified as rhabdomyosarcoma, carrying EWSR1-FLI1 type 1 fusion, BRAF V600E, and mutant TP53.
A-704
A-704 (A.704, A704, CVCL_1065, ATCC HTB-45) is a human renal cell carcinoma epithelial cell line established in 1973 from a 78-year-old male kidney adenocarcinoma; VHL-null, PBRM1-negative, TP53-mutant, ccA subtype, non-tumorigenic in mice.
A2058
A2058 (CVCL_1059) is a human amelanotic metastatic melanoma cell line from a 43-year-old male's lymph node metastasis, BRAF V600E mutant, BRAF-inhibitor resistant, doubling in 27 hours, held as ATCC CRL-3601.
A2780
A2780 is a widely used human ovarian cancer cell line, drug-naive because it came from an untreated patient, and parent to over 40 drug-resistant sublines for studying chemotherapy resistance.
A4573
A4573 (CVCL_6245, also A-4573, ES-A4573) is a human Ewing sarcoma cell line from a metastatic pleural effusion of a 17-year-old female, carrying t(11;22), used widely in drug-resistance and pharmacogenomics studies.
ACHN
ACHN (CVCL_1067, ATCC CRL-1611) is a human renal cell carcinoma cell line begun in 1979 from a pleural effusion of a 22-year-old man; genomically papillary, VHL wild type, NCI-60 member.
Air-liquid interface culture
Air-liquid interface culture is a cell culture method where epithelial cells grow on a porous membrane, basal side in medium and apical side in air, producing differentiated tissue-like epithelia.
AMAI
AMAI (AMAL, CVCL_E455) is an EBV-transformed human B-lymphoblastoid cell line from an Algerian male donor, part of the 10th International Histocompatibility Workshop panel, used as an HLA typing reference.
ARPE-19
ARPE-19 (Adult Retinal Pigment Epithelial cell line-19) is a spontaneously immortalized human retinal pigment epithelial cell line derived in 1986 from a 19-year-old male donor, widely used in ocular drug discovery.
AsPC-1
AsPC-1 (CVCL_0152, ATCC CRL-1682) is a human pancreatic ductal adenocarcinoma cell line established in 1982 from the ascites of a 62-year-old woman, carrying homozygous KRAS G12D, SMAD4 R100T, and CDKN2A frameshift mutations, used in drug screening and metastasis research.
B-CPAP
B-CPAP (BCPAP, CVCL_0153) is a human thyroid carcinoma cell line established in 1992 from a 76-year-old woman, now classified as poorly differentiated thyroid carcinoma, carrying BRAF V600E, TERT promoter, and TP53 mutations.