400 articles
Caov-3
Caov-3 (CAOV-3, CVCL_0201, ATCC HTB-75) is a human ovarian adenocarcinoma cell line isolated in 1976 by Jorgen Fogh from a 54-year-old woman, with TP53 nonsense mutation, PIK3CA amplification, and wide use in HGSOC research.
Capan-1
Capan-1 (CAPAN-1, ATCC HTB-79) is a human pancreatic ductal adenocarcinoma cell line established in 1974 from a liver metastasis by Jorgen Fogh at MSK; it carries BRCA2 6174delT, KRAS G12V, SMAD4-null and TP53 mutations and is 5-fluorouracil resistant.
Capan-2
Capan-2 (CAPAN-2, CVCL_0026, ATCC HTB-80) is a human pancreatic ductal adenocarcinoma cell line isolated in 1975 from a 56-year-old male, with polygonal morphology, KRAS G12V, and well-differentiated xenograft tumor formation.
CaR-1
CaR-1 (CaR1, CAR1; CVCL_1116, JCRB0207) is a human rectal adenocarcinoma cell line from a 70-year-old Japanese man's inguinal lymph node metastasis, established in 1977, MSS, with homozygous TP53 p.Val272Met, distinct from CAR receptors and CAR-T.
CCRF-HSB-2
CCRF-HSB-2 (HSB-2, CVCL_1859) is a human T-lymphoblast leukemia cell line established in 1966 from an 11-year-old boy, EBV-negative, carrying STIL-TAL1 and LCK-TCRB fusions, and flagged as partially contaminated.
Cell cryopreservation
Cell cryopreservation is the preservation of living cells by cooling them to cryogenic temperatures, typically with 10% DMSO and storage in liquid nitrogen vapor, underpinning cell banking and cell therapy.
Cell line authentication
Cell line authentication is a quality-control procedure that verifies a cultured cell line's identity, done almost entirely by STR profiling, now required by many funders and journals.
CFPAC-1
CFPAC-1 (CF PAC-1, CVCL_1119, ATCC CRL-1918) is a human pancreatic ductal adenocarcinoma cell line from a 26-year-old male with cystic fibrosis, homozygous for CFTR ΔF508, KRAS G12V, TP53 C242R, SMAD4-deleted, gemcitabine-sensitive.
Chang Liver
Chang Liver is a human cell line established in 1954 by R. Shihman Chang and long used as a liver model, later shown to be a HeLa derivative.
CHL-1
CHL-1 (CHL1, CVCL_1122) is a human amelanotic melanoma cell line from a 36-year-old woman's pleural effusion metastasis, a derivative of RPMI 7932, held as ATCC CRL-3619, with TP53, CDKN2A, MAPK3, and TERT promoter mutations.
CHO-K1
CHO-K1 (ATCC CCL-61, ECACC 85051005) is a proline-auxotrophic, adherent subclone of the Chinese hamster ovary cell line established by T.T. Puck in 1957; ancestral to CHO-DXB11 and CHO-DG44 and widely used as a transfection and bioproduction host.
CHO-S
CHO-S is a suspension-adapted Chinese hamster ovary cell line, reported by Thompson and coworkers in 1973, used as a host for recombinant protein production in serum-free suspension culture.
CHSE-214
CHSE-214 (Chinook Salmon Embryo-214, ATCC CRL-1681, RRID:CVCL_2780) is a spontaneously immortalized Chinook salmon embryo cell line originated in 1964, grown at 21°C, and widely used for fish virus isolation, especially IHNV and IPNV.
CL-11
CL-11 (CVCL_1978, RRID:CVCL_1978), also written CL11, is a human colon adenocarcinoma cell line from a left-colon primary tumor, DSMZ ACC-467, microsatellite-stable, male, with KRAS, FBXW7, and TP53 mutations; distinct from the collectin-11 protein.
CME W1 cl.8+
CME W1 cl.8+ (Clone 8, Cl.8, CVCL_Z790) is a spontaneously immortalized Drosophila melanogaster cell line cloned from CME W1, derived from male third instar wing imaginal disc, ecdysone-susceptible, a modENCODE core line, DGRC stock 151.
CMT12
CMT12 (CMT-12, CVCL_L329) is a canine mammary carcinoma cell line derived from a Poodle papillary adenocarcinoma, formerly named CMT-2, with homozygous KMT2C and TP53 mutations, constitutive COX-2 overexpression, and FACC panel membership.
Co-115
Co-115 (CVCL_D102, RRID:CVCL_D102) is a human colon adenocarcinoma cell line established in 1976 from a nude-mouse xenograft of a 77-year-old woman's ascending colon tumor; MSI, BRAF V600E, PTEN mutations, CMS1 subtype.
Co-culture (cell biology)
Co-culture, or cell co-culture, is a laboratory method that grows two or more cell types together in one vessel so their signaling interactions can be studied directly.
Coculture
Coculture is a cell culture technique in which two or more distinct cell types are grown together in one vessel so their interactions and signaling can be studied directly.
COLO 205
COLO 205 (COLO-205, CVCL_0218) is a human colon adenocarcinoma cell line from the ascitic fluid of a 70-year-old male with Dukes type D colon cancer; mixed adherent/suspension growth, BRAF V600E, KRAS wild type, MSS, NCI-60 panel member.
Cultured cell
Cultured cell: a human, plant, or animal cell adapted to grow in the laboratory, also called cell culture material. Distinguished by culture type (primary, immortalized like HeLa, stem cells), standard 37°C/5% CO2 conditions, and uses in drug testing and research.
CW-2
CW-2 (CW2, CVCL_1151, RCB0778) is a human colon adenocarcinoma cell line from a 55-year-old Japanese woman, CEA-positive, MSI-high, with KRAS Pro140His and TP53 Pro47Pro mutations, used in colorectal cancer and drug screening research.
D425 Med
D425 Med (CVCL_1275, RRID:CVCL_1275) is a human Group 3 medulloblastoma cell line from a 6-year-old male, MYC- and OTX2-amplified with mutant TP53, used widely in xenograft and therapy studies.
Daoy
Daoy, also written DAOY, is a continuous human cell line established in 1985 from a 4-year-old boy's cerebellar medulloblastoma, used as a standard laboratory model of the childhood brain tumor.
Detroit 562
Detroit 562 (CVCL_1171, ATCC CCL-138) is a human pharyngeal squamous cell carcinoma cell line from a female patient's metastatic pleural effusion; HPV-negative, TP53 R175H and PIK3CA H1047R mutant, widely used HNSCC model.
Detroit 6
Detroit 6 (Det-6, CVCL_2436) is a human cancer cell line described in 1956 as sternal marrow from a male lung carcinoma patient but shown by Gartler and later work to be a HeLa derivative carrying HPV18.
DiFi
DiFi (DIFI, CVCL_6895) is a human colorectal cancer cell line from a familial adenomatous polyposis (Gardner syndrome) patient, derived from metastatic ascites; MSS, EGFR-amplified, and exquisitely cetuximab-sensitive, with the DiFi5 resistant subline.
DLD-1
DLD-1 (DLD1, CoCL3, ATCC CCL-221) is a human colorectal adenocarcinoma cell line isolated 1977-1979 from a male patient; known for clonal heterogeneity (clones A and D) and shared origin with HCT-15, HCT-8, and HRT-18.
ECV-304
ECV-304 (CVCL_2029), a human cell line described in 1990 as spontaneously transformed umbilical vein endothelial cells but shown in 1999 to be a T24 bladder carcinoma derivative; ICLAC-00117, still used in endothelial and vasculogenic mimicry studies.
Ex vivo cell expansion
Ex vivo cell expansion is a cell culture technique that grows cells removed from a living organism outside the body to increase their numbers for research and cell therapy manufacture.