77 articles
5A2-SC8
5A2-SC8 is a degradable, dendrimer-based ionizable amino lipid, selected from a library of over 1,500 candidates, whose lipid nanoparticles deliver siRNA, mRNA, and CRISPR-Cas9 cargoes, primarily to the liver.
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
A 2018 Nature Biotechnology paper by Suping Li and colleagues in Beijing reporting a DNA origami nanorobot that delivers thrombin to tumor vessels in mice.
A molecular robot that can detect and kill cancer cells
A molecular robot that can detect and kill cancer cells is a DNA-built nanoscale device that senses tumor markers and acts, demonstrated so far only in mice.
Aglatimagene besadenovec
Aglatimagene besadenovec (CAN-2409) is Candel Therapeutics' replication-defective adenovirus delivering the HSV thymidine kinase gene, injected into tumors with valacyclovir prodrug; positive phase 3 in localized prostate cancer, phase 2a in NSCLC, not yet approved.
ALC-0315
ALC-0315 is a biodegradable synthetic ionizable cationic lipid that binds mRNA in the Pfizer–BioNTech COVID-19 vaccine's lipid nanoparticles, condensing it during manufacture and aiding its release inside cells.
ApoE-mediated uptake of lipid nanoparticles
ApoE-mediated uptake is the process by which serum apolipoprotein E adsorbs onto lipid nanoparticles and directs them to hepatocytes via the LDL receptor, driving their liver tropism.
APP13007 (clobetasol propionate nanoparticle ophthalmic suspension)
APP13007 (BYQLOVI), clobetasol propionate ophthalmic suspension 0.05%, an APNT nanoparticle steroid eye drop FDA-approved March 2024 for post-operative inflammation and pain after ocular surgery, dosed twice daily for 14 days.
Aptamer-functionalized nanoparticles
Aptamer-functionalized nanoparticles are drug-delivery or diagnostic particles whose surfaces carry aptamers, short DNA or RNA strands that bind specific molecular targets, most often receptors overexpressed on cancer cells.
ASGPR-mediated GalNAc conjugate uptake
ASGPR-mediated GalNAc conjugate uptake is the delivery mechanism by which GalNAc ligands on oligonucleotide drugs bind the asialoglycoprotein receptor on hepatocytes, enabling receptor-mediated endocytosis of most approved siRNA therapeutics.
Barcoded nanoparticles
Barcoded nanoparticles are drug delivery particles tagged with unique DNA markers, so dozens to hundreds of nanoparticle formulations can be tested in a single animal via sequencing.
Carbon nanotube drug delivery
Carbon nanotube drug delivery uses functionalized carbon nanotubes as carriers for drugs, genes, and imaging agents, with cancer therapy the most heavily studied application, though clinical use remains limited.
Cell hitchhiking
Cell hitchhiking is a drug delivery strategy in which nanoparticles ride on blood cells such as red blood cells, evading immune clearance and extending circulation.
Cell membrane-coated nanoparticles
Cell membrane-coated nanoparticles, also called cellular nanoparticles, consist of a synthetic core cloaked with membrane from a source cell such as a red blood cell, first reported in 2011.
Chitosan nanoparticles
Chitosan nanoparticles are drug-delivery particles, typically tens to hundreds of nanometers wide, made from chitosan, a positively charged polysaccharide derived from crustacean shells, studied for drug and gene delivery.
CRISPR–Cas9 delivery
CRISPR–Cas9 delivery is the set of methods used to transport the Cas9 genome-editing machinery into cells, widely considered the main barrier to in vivo CRISPR therapy.
Cyclodextrin nanoparticles
Cyclodextrin nanoparticles are drug-delivery particles in which cyclodextrins, cyclic sugars with hydrophobic cavities, improve the solubility, stability, and targeting of drugs, most notably in cancer therapy.
Dextranomer
Dextranomer (Debrisan, Deflux, Solesta) is a cross-linked dextran polymer used as wound-cleansing beads and, with hyaluronic acid, as an injectable bulking agent for vesicoureteral reflux and fecal incontinence.
DNA origami drug delivery
DNA origami drug carriers are nanoscale delivery vehicles made by folding a long DNA scaffold with short staple strands, introduced at Caltech in 2006 and loaded with drugs like doxorubicin.
Drug Carriers
Drug carriers are macromolecules, polymers, or nanoparticles that transport and release pharmacologically active compounds, prolonging drug action, reducing metabolism and toxicity. Key platforms include liposomes, SLNs, NLCs, polymeric nanoparticles, and LNPs, from Doxil (1995) to mRNA-LNP COVID-19 vaccines.
Exosome-based drug delivery
Exosome-based drug delivery uses exosomes, nanosized vesicles secreted by most cells, as natural carriers of drugs and nucleic acids, with low toxicity and inherent targeting.
Exosome-mediated siRNA delivery
Exosome-mediated siRNA delivery uses exosomes, nano-sized vesicles cells naturally release, to deliver small interfering RNA into target cells, with advantages in biocompatibility, low toxicity, and crossing barriers like the brain.
Ferritin nanocage drug delivery
Ferritin nanocage drug delivery uses ferritin, a hollow iron-storage protein that self-assembles into a 12 nm cage, to carry drugs, imaging agents, and therapeutic proteins into tumor cells.
Fullerene drug delivery
Fullerene drug delivery is the use of fullerene cages, most often the 60-carbon C60 buckyball, as nanoscale carriers that deliver drugs to target tissues, especially in combined chemo-photodynamic cancer therapy.
GalNAc conjugate delivery
GalNAc conjugate delivery is a drug-delivery strategy that attaches N-acetylgalactosamine sugar to siRNA or antisense oligonucleotides, letting hepatocytes take them up via the ASGPR receptor.
GalNAc-siRNA conjugate
A GalNAc-siRNA conjugate is a small interfering RNA linked to a GalNAc sugar cluster that delivers gene silencing to liver hepatocytes, first approved as givosiran in 2019.
GalNAc-siRNA conjugate delivery
GalNAc-siRNA conjugate delivery is a technology linking small interfering RNA to GalNAc, a sugar whose hepatocyte receptor concentrates it in the liver, the standard for liver-targeted RNAi therapeutics since givosiran's 2019 approval.
Graphene oxide drug delivery
Graphene oxide drug delivery is an experimental nanomedicine approach that uses graphene oxide nanosheets to load, transport, and release drugs and genes, reported in 2008 and still preclinical.
Injectable cryogel
An injectable cryogel scaffold is a macroporous hydrogel, made by cryogelation at subzero temperatures, that can be injected through a needle and regains its shape.
Injectable peptide hydrogel for spinal cord repair
An injectable peptide hydrogel for spinal cord repair is a biomaterial injected as a liquid that gels to support regeneration; Northwestern's "dancing molecules" restored walking in paralyzed mice in 2021.
Ionizable lipid pKa optimization
Ionizable lipid pKa optimization tunes the protonation of ionizable lipids in lipid nanoparticles so they deliver RNA cargo efficiently, as in Onpattro and COVID-19 mRNA vaccines.