77 articles
Nitric oxide-releasing nanoparticles
Nitric oxide-releasing nanoparticles are nanoscale drug-delivery vehicles that store nitric oxide donors and release the gas at target tissues, addressing its extremely short half-life and imprecise delivery.
PEGylated nanographene
PEGylated nanographene is nanoscale graphene oxide grafted with polyethylene glycol, giving water solubility, longer blood circulation, and passive tumor targeting; it remains limited to preclinical cancer drug delivery research.
PEI-PEG polyplex
A PEI-PEG polyplex is a non-viral gene delivery particle in which polyethylenimine (PEI) condenses nucleic acids and a polyethylene glycol (PEG) shell reduces toxicity, aggregation, and blood clearance.
Personalized protein corona
The personalized protein corona (PPC) is the patient-specific layer of proteins that forms on a nanoparticle in blood plasma, giving the same particle different biological behavior in each patient.
Phytosome
A phytosome, also called a phyto-phospholipid complex or herbosome, is a delivery system that binds plant-derived actives to phosphatidylcholine to improve absorption, patented by Indena in 1989.
PLGA nanoparticles
PLGA nanoparticles are submicron drug carriers made from poly(lactic-co-glycolic acid), a biodegradable and biocompatible FDA-approved copolymer, widely used for controlled and targeted delivery of small molecules, proteins, vaccines, and nucleic acids.
Poly(2-oxazoline) drug conjugates
Poly(2-oxazoline) drug conjugates are polymer therapeutics in which drugs are attached to POx carrier polymers, improving solubility and tumor accumulation; developed as PEG alternatives, their clinical lead SER-252 targets Parkinson's disease.
Polyplex
A polyplex is a non-viral gene delivery particle in which a cationic polymer, such as polyethylenimine, electrostatically condenses DNA or RNA into nanoscale complexes that carry nucleic acids into cells.
Porous silicon nanoparticles
Porous silicon nanoparticles (pSiNPs) are biodegradable silicon particles with tunable nanoscale pores, studied for targeted drug delivery, biosensing, and implant coatings; no clinical trials yet.
Selective organ targeting (SORT) of lipid nanoparticles
Selective organ targeting (SORT) is a lipid nanoparticle engineering strategy that redirects mRNA and CRISPR delivery from the liver to organs like the lungs and spleen.
Solid lipid nanoparticles
Solid lipid nanoparticles (SLNs) are submicron colloidal carriers of 50–1000 nm made of lipids solid at room and body temperature, developed in the early 1990s to carry and release drugs.
SORT lipid nanoparticles for gastrointestinal delivery
SORT lipid nanoparticles for gastrointestinal delivery use an added fifth lipid to direct mRNA delivery to the stomach, pancreas, and colon instead of the liver.
ssPalm
ssPalm is a gemini ionizable lipid for intracellular delivery of nucleic acids, developed by Hidetaka Akita's group in Japan, whose particles escape endosomes and release cargo on disulfide cleavage.
Stimuli-responsive nanoparticles
Stimuli-responsive nanoparticles are drug-delivery particles that release cargo in response to triggers like pH, redox state, enzymes, light, ultrasound, or heat, aiming to boost efficacy and cut toxicity.
Theranostic Nanomedicine
Theranostic nanomedicine, or nanotheranostics, integrates diagnostic imaging and targeted therapy in a single nanoparticle platform. Key examples include NBTXR3 hafnium oxide radioenhancers, NanoTherm iron oxide glioma therapy, and ferumoxytol MRI agents; translation is limited by heterogeneity, manufacturing, and regulation.
Tumor penetration of nanoparticles
Tumor penetration of nanoparticles is the transport of nanoscale drug carriers from tumor vessels through tissue to reach cancer cells deep within solid tumors, a key obstacle in cancer nanomedicine.
Ultrasound-triggered drug release
Ultrasound-triggered drug release is a drug delivery strategy in which externally applied ultrasound causes carriers such as microbubbles, liposomes, and nanoparticles to release drugs at a chosen body site.