25,729 articles
Acceptance and commitment therapy
Acceptance and commitment therapy (ACT) is a psychotherapy developed by Steven C. Hayes in the early 1980s that uses acceptance, mindfulness, and values to build psychological flexibility.
Accessory auricle
Accessory auricle (polyotia, preauricular tag; ICD-11 LA24, ICD-10 Q17.0) is a congenital auricular appendage from persistent first pharyngeal arch hillocks, sometimes syndromic, treated by excision or clip ligation.
Accessory bile duct
Accessory bile duct, including double common bile duct and subvesical ducts, a congenital extra biliary channel; rare (<50 ACBD cases), embryologically from failed duct fusion, a cause of postcholecystectomy bile leaks.
Accessory fallopian tube
Accessory fallopian tube, also called fallopian tube duplication or supernumerary tube: a congenital extra tube attached to the ampulla of the main tube, first described by Kossman in 1894, found in roughly 5-6% of abdominal operations, and linked to infertility, ectopic pregnancy, pyosalpinx, and torsion.
Accessory lobe of lung
Accessory lobe of lung (supernumerary lung lobe, 副肺葉): a congenital extra lung lobe separated by an accessory fissure; ICD-10 Q33.1, ICD-11 LA75.0; azygos lobe prevalence 0.4–1.2%.
Accessory mitral valve tissue
Accessory mitral valve tissue is a rare congenital cardiac anomaly in which extra mitral valve tissue causes left ventricular outflow tract obstruction, heart failure, or embolic events.
Accessory nail of the fifth toe
Accessory nail of the fifth toe, or double nail of the fifth toe (petaloid toenail), is a common heritable trait in which a tiny sixth toenail, 2–7 mm long, sits at the outer corner of the little toenail; often asymptomatic, treated by matricectomy.
Accessory nerve
Accessory nerve (CN XI, spinal accessory nerve), a mostly motor cranial nerve named for Thomas Willis, innervates the sternocleidomastoid and trapezius, exits via the jugular foramen, and is injured mainly during neck surgery, causing shoulder dysfunction.
Accessory ovary
Accessory ovary: a rare congenital third ovary located near and connected to a normal (eutopic) ovary, also called ectopic ovarian tissue. Incidence about 1 in 29,000 to 700,000 gynecologic admissions; usually asymptomatic, found incidentally, and capable of cysts, torsion, and tumors.
Accessory pancreas
Accessory pancreas, also called heterotopic or ectopic pancreas, is congenital pancreatic tissue outside the main gland, without anatomic or vascular connection, found mostly in the stomach and duodenum, usually asymptomatic, ICD-10 Q45.3.
Accessory pathway
Accessory pathway: an abnormal atrioventricular muscle bridge bypassing the AV node, causing pre-excitation (WPW pattern), AVRT, and risk of pre-excited AF; risk-stratified by EP study and cured by catheter ablation.
Accessory rib
Accessory rib (supernumerary rib), most often the cervical rib from C7, also lumbar or intrathoracic; congenital extra rib, prevalence about 1%, can cause thoracic outlet syndrome.
Accessory spleen
Accessory spleen (splenunculus, splenule): congenital ectopic splenic tissue, distinct from splenosis. Present in about 14.5% of people, usually near the splenic hilum; can cause hematologic recurrence after splenectomy and mimic tumors on imaging.
Accessory tricuspid valve tissue
Accessory tricuspid valve tissue (ORPHA:95462, ICD-10 Q22.8) is a rare congenital tricuspid valve malformation, usually with other congenital heart defects, causing murmurs, dyspnea, cyanosis, or outflow obstruction; treated by surgical excision.
Accident
Accident: an unpremeditated event causing recognizable damage (WHO definition). Public health now prefers "injury"; 4.4 million injury deaths yearly, 90% in low- and middle-income countries, largely preventable via energy-control strategies.
Accident Insurance
Accident insurance pays fixed benefits for death, dismemberment, disability, or medical costs from accidental injury. Commercial personal accident cover began in railway-age England (1848-1849); Germany's 1884 Bismarck law founded statutory accident insurance.
Accident Prevention
Accident prevention, also called injury prevention or safety promotion, is the organized effort to reduce accidental injuries through hazard elimination, engineering controls, regulation, and education, spanning workplace, road, home, and community safety.
Accommodation reflex
Accommodation reflex (near response, near triad): a three-part reflex for near vision, lens thickening via ciliary muscle, pupillary constriction, and convergence, mediated by the Edinger-Westphal nucleus, oculomotor nerve, and ciliary ganglion.
Accreditation Council for Graduate Medical Education
The Accreditation Council for Graduate Medical Education (ACGME) is a private nonprofit body, established in 1981, that sets standards for and accredits US residency and fellowship programs.
Accredited Social Health Activist
Accredited Social Health Activist (ASHA), India's community health worker cadre created in 2005 under the National Rural Health Mission; about one million trained women, one per ~1,000 people, honorary volunteers paid by performance incentives, bridging villages and public health services.
ACE inhibitor
ACE inhibitors are drugs blocking angiotensin-converting enzyme to treat hypertension and heart failure; developed from Bothrops jararaca venom peptides, first drug captopril (1981), followed by enalapril, lisinopril, ramipril.
Aceclidine
Aceclidine: a cholinergic muscarinic agonist miotic, long approved in Europe for glaucoma; approved in the US July 31, 2025 as VIZZ 1.44% (LNZ100, LENZ Therapeutics), a once-daily drop for adult presbyopia.
Aceclofenac
Aceclofenac is an oral NSAID prodrug of diclofenac, launched in Spain in 1984, used for osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, acting through sustained conversion to diclofenac with COX-1 sparing.
ACEEMR study
ACEEMR (Australian Multicentre Colonic Endoscopic Mucosal Resection Study, ACE/EMR, NCT01368289) is a prospective Australian observational study of EMR for sessile colorectal polyps ≥20 mm, led by Michael Bourke, basis of the ACE cohort and recurrence, bleeding, and cancer-risk findings.
Acefylline
Acefylline (acephylline, acepifylline), an N-7-substituted theophylline xanthine bronchodilator (C9H10N4O4, CAS 652-37-9) for asthma and bronchitis; European Pharmacopoeia-listed, no separate FDA approval, efficacy questioned since 1978.
Acemetacin
Acemetacin (Rantudil, Emflex, TV 1322) is a glycolic acid ester prodrug of indomethacin, a non-steroidal anti-inflammatory drug for rheumatoid arthritis, osteoarthritis, low back pain, and postoperative pain, with better gastric tolerability than indomethacin.
Aceneuramic acid
Aceneuramic acid (N-acetylneuraminic acid, sialic acid; SA-ER, Ace-ER, ACENOBEL) is an oral extended-release replacement therapy for GNE myopathy, approved in Japan after phase II/III trials showing slowed upper limb strength loss.
Acenocoumarol
Acenocoumarol, also known as nicoumalone and sold as Sintrom, is a coumarin oral anticoagulant, a vitamin K antagonist used mainly in Europe against thromboembolic disease.
Acephaly
Acephaly (acephalia, congenital absence of head) is the complete congenital absence of the head, distinct from anencephaly. It occurs mainly in acardiac twins with TRAP sequence, is extremely rare in singletons, and is coded ICD-11 LA00.2.
Aceruloplasminemia
Aceruloplasminemia (hereditary ceruloplasmin deficiency) is a rare autosomal recessive NBIA disorder caused by CP gene mutations, causing brain and visceral iron overload, anemia, diabetes, retinal degeneration, and adult-onset neurological decline.