25,729 articles
Currarino syndrome
Currarino syndrome (Currarino triad) is a rare autosomal dominant congenital disorder caused by MNX1 mutations, defined by anorectal malformation, sacral agenesis, and presacral mass, with 1-2% malignancy risk and variable expressivity.
Current Procedural Terminology
Current Procedural Terminology (CPT) is the AMA-maintained five-digit US code set for reporting medical procedures and services, HCPCS Level I under HIPAA, with over 11,000 codes driving Medicare RVU payment.
Curry-Jones syndrome
Curry-Jones syndrome (corpus callosum agenesis-polysyndactyly syndrome, OMIM 601707) is a rare mosaic disorder caused by SMO c.1234C>T, with craniosynostosis, polysyndactyly, skin, eye, gut anomalies, and medulloblastoma risk.
Curtis Prout
Curtis Prout (1915–2011) was a Harvard-trained American physician and leading figure in prison medicine who founded the National Commission on Correctional Health Care and wrote Care and Punishment (1988).
Cushing reflex
Cushing reflex (vasopressor response, Cushing reaction): physiological response to acute intracranial pressure elevation, producing Cushing's triad of widened pulse pressure, bradycardia, and irregular respirations; proposed by Harvey Cushing in 1901.
Cushing syndrome due to bilateral macronodular adrenocortical disease
Cushing syndrome due to bilateral macronodular adrenocortical disease (BMAD, also PBMAH), a rare ACTH-independent adrenal Cushing syndrome from bilateral >1 cm benign adrenal macronodules; ARMC5 and KDM1A genes, prevalence under 1 per million.
Cushing syndrome due to ectopic ACTH secretion
Ectopic ACTH syndrome (ectopic Cushing's syndrome): Cushing's syndrome caused by non-pituitary tumors, usually SCLC or bronchial carcinoids, secreting ACTH; diagnosed via IPSS and PET/CT, treated by resection or adrenalectomy.
Cushing's disease
Cushing's disease, also known as Itsenko-Cushing's disease, is a disorder in which a benign ACTH-secreting pituitary tumor drives cortisol overproduction, and the most common cause of endogenous Cushing's syndrome.
Cushing's syndrome
Cushing's syndrome, also called hypercortisolism, results from prolonged excess cortisol, most often from glucocorticoid drugs; endogenous cases are usually ACTH-dependent pituitary Cushing's disease, with diagnosis by urinary, salivary, and dexamethasone suppression tests and elevated mortality.
Custirsen
Custirsen (OGX-011, ISIS 112989, custirsen sodium) is a second-generation antisense oligonucleotide inhibiting clusterin; phase 3 SYNERGY and AFFINITY trials showed no survival benefit in prostate cancer.
Custodial Care
Custodial care: long-term, non-medical help with activities of daily living (bathing, dressing, eating), also called long-term care. Distinct from skilled care; excluded from Medicare coverage, mainly paid privately or by Medicaid in nursing homes.
Cutaneous Administration
Cutaneous administration delivers drugs through the skin, spanning topical local action and transdermal systemic delivery via patches. Key facts: stratum corneum barrier, sub-500 Da drug criteria, 1979 scopolamine first patch, enhancement methods.
Cutaneous amoebiasis
Cutaneous amoebiasis (amebiasis cutis), rare skin and soft-tissue infection by Entamoeba histolytica trophozoites, usually secondary to intestinal or hepatic amoebiasis; painful necrotic anogenital ulcers, erythrophagocytosis on histology, metronidazole treatment.
Cutaneous collagenous vasculopathy
Cutaneous collagenous vasculopathy (CCV), a rare idiopathic skin microangiopathy first described in 2000, causing widespread telangiectasias from type IV collagen vessel wall thickening; distinguished from generalized essential telangiectasia by biopsy.
Cutaneous cysts
Cutaneous cysts (skin cysts, ICD-11 EK70) are epithelium-lined sacs in the skin filled with keratin, sebum, or fluid. Main types: epidermoid cyst, milium, pilar (trichilemmal) cyst; mostly benign, rarely malignant.
Cutaneous diphtheria
Cutaneous diphtheria, skin diphtheria caused by toxin-producing Corynebacterium diphtheriae or C. ulcerans, presents as slow-healing ulcers or scaling rash; now the majority form of diphtheria in outbreaks, treated with antibiotics and vaccination.
Cutaneous epithelioid angiomatous nodule
Cutaneous epithelioid angiomatous nodule (CEAN) is a rare benign vascular skin tumor first described by Brenn and Fletcher in 2004, with about 65 reported cases, solid epithelioid endothelial cells, CD31/CD34/ERG positivity, and no recurrences after excision.
Cutaneous erythema multiforme
Cutaneous erythema multiforme (ICD-11 EB12.0, erythema multiforme minus) is skin-confined erythema multiforme, typically triggered by recurrent herpes simplex infection, marked by target lesions and distinguished from mucocutaneous EB12.1 disease.
Cutaneous horn
Cutaneous horn (cornu cutaneum, keratin horn): a hard conical keratin projection from the skin, usually in older fair-skinned adults on sun-exposed sites; roughly half have benign bases, half premalignant or malignant ones, requiring excision biopsy of the base.
Cutaneous larva migrans
Cutaneous larva migrans, or creeping eruption, is a parasitic skin disease in which dog or cat hookworm larvae migrate under human skin, leaving an intensely itchy, winding red track.
Cutaneous leishmaniasis
Cutaneous leishmaniasis (CL), also called Oriental sore, is the most common form of leishmaniasis: skin ulcers caused by Leishmania parasites transmitted by female phlebotomine sandflies, with 600,000 to 1 million estimated annual cases.
Cutaneous leukocytoclastic vasculitis
Cutaneous leukocytoclastic vasculitis (LCV, hypersensitivity vasculitis, cutaneous leukocytoclastic angiitis) is a skin-limited small-vessel vasculitis causing palpable purpura on the lower extremities, diagnosed by biopsy showing neutrophilic infiltrate, leukocytoclasia, and fibrinoid necrosis; about 90% of idiopathic cases resolve in weeks to months.
Cutaneous listeriosis
Cutaneous listeriosis, skin infection by Listeria monocytogenes (ICD-10 A32.0, ICD-11 1C1A.0): rare self-limited papulopustular rash after direct inoculation, mainly in veterinarians and farmers exposed to bovine abortions.
Cutaneous lymphangiectasia
Cutaneous lymphangiectasia (acquired lymphangioma, lymphangiectasis) is dilation of superficial skin lymphatic vessels after obstruction or injury, causing frogspawn-like oozing vesicles, cellulitis risk, and treatments including CO2 laser, sclerotherapy, and excision.
Cutaneous mastocytoma
Cutaneous mastocytoma (solitary mastocytoma), a form of cutaneous mastocytosis, is a benign hyperpigmented skin nodule of mast cell accumulation, usually presenting in infancy, with Darier sign, and spontaneous resolution before puberty.
Cutaneous mucinosis
Cutaneous mucinosis (mucinoses) is a group of uncommon skin disorders with abnormal mucin (hyaluronic acid) deposition in dermis or follicles, classified as primary or secondary, dermal or follicular, including scleromyxedema, follicular mucinosis, and focal mucinosis.
Cutaneous nocardiosis
Cutaneous nocardiosis is a skin infection by Nocardia bacteria, usually N. brasiliensis, acquired by traumatic inoculation or via disseminated disease; treated with trimethoprim-sulfamethoxazole.
Cutaneous non-tuberculous mycobacterial infection
Cutaneous non-tuberculous mycobacterial infection (ICD-11 1B21.2): skin and soft tissue infection from environmental NTM, mostly rapid growers like M. abscessus, M. fortuitum, M. chelonae, acquired via trauma, surgery, or injections, diagnosed by culture, treated with months of multidrug therapy.
Cutaneous pseudolymphoma
Cutaneous pseudolymphoma, also called cutaneous lymphoid hyperplasia or lymphocytoma cutis, is a benign reactive skin lymphoproliferation mimicking lymphoma clinically and histologically, divided into T-cell and B-cell types, caused by infections, drugs, tattoos, or bites.
Cutaneous sarcoidosis
Cutaneous sarcoidosis: skin involvement by sarcoidosis, occurring in 20-35% of patients, often the first sign. Specific lesions (lupus pernio, papules, plaques) show noncaseating granulomas; diagnosis requires biopsy plus exclusion of mimics.