25,729 articles
D2 lymphadenectomy
D2 lymphadenectomy is the surgical removal of the stomach's regional lymph nodes to a defined second echelon during gastrectomy for gastric cancer, standard in Japanese guidelines and high-volume European centers.
D3-creatine dilution
D3-creatine dilution (D3Cr) is a stable-isotope test measuring total skeletal muscle mass from one oral dose of deuterated creatine and a urine sample, validated against MRI.
D341 Med
D341 Med (D-341 Med, CVCL_0018, ATCC HTB-187) is a human group 3 medulloblastoma cell line established in 1988 from a 3.5-year-old boy's cerebellar tumor, grown in suspension spheroids with 20-fold c-myc amplification.
Da Costa's syndrome
Da Costa's syndrome, or irritable heart, soldier's heart, effort syndrome, or neurocirculatory asthenia, is a functional cardiac disorder with effort intolerance, palpitations, and breathlessness described by Jacob Mendes Da Costa in 1871.
Da Jian Zhong Tang
Da Jian Zhong Tang (大建中汤; Japanese daikenchuto, TJ-100) is a classical Chinese warm-interior formula from the Jingui Yaolüe, combining Sichuan pepper, dried ginger, ginseng, and maltose for severe cold abdominal pain, now studied in Japan for postoperative ileus.
Da Qinjiao Tang
大秦艽汤 (Da Qinjiao Tang, Major Gentiana Decoction), a 16-herb classic Chinese formula from Liu Wansu's Suwen Bingji Qi Yi Baoming Ji, dispels wind, clears heat, and nourishes blood for wind-stroke channel patterns; entry 54 of China's classical formula directory.
Da Vinci Surgical System
The da Vinci Surgical System, also known as the da Vinci robot, is a robotic surgery device made by Intuitive Surgical that lets a seated surgeon control instruments through small incisions via a console.
Dabigatran
Dabigatran (Pradaxa), oral direct thrombin inhibitor prodrug dabigatran etexilate; first DOAC, FDA-approved 2010 after RE-LY; 150 mg bid for nonvalvular AF stroke prevention, renal dosing, reversed by idarucizumab.
Dabocemagene autoficel
Dabocemagene autoficel (D-Fi, FCX-007) is Castle Creek Biosciences' investigational ex vivo autologous lentiviral COL7A1 fibroblast gene therapy for dystrophic epidermolysis bullosa wounds, in phase 3 trials NCT04213261 and NCT06892639.
Dabrafenib/trametinib regimen
The dabrafenib/trametinib regimen, also called dabrafenib and trametinib, is an oral targeted-therapy combination that blocks the MAPK pathway in BRAF V600-mutated cancers, first FDA-approved for melanoma in 2014.
Dabu Yuanjian
大补元煎 (Da Bu Yuan Jian), a classic Chinese medicine decoction from Zhang Jiebin's Ming-era Jingyue Quanshu; eight herbs led by ginseng and prepared rehmannia, treating severe qi-blood collapse; listed in China's 2023 Ancient Classic Formulas catalogue.
Dabur
Dabur, also known as Dabur India Limited, is an Indian consumer goods company founded by Dr. S. K. Burman in 1884, known for Ayurvedic products like Chyawanprash and Real.
DACAMI trial
DACAMI (NCT05424315) was a 2023 Egyptian dual-center randomized trial testing dapagliflozin 10 mg versus placebo in 100 non-diabetic anterior STEMI patients, showing greater NT-proBNP and LV mass index reductions.
Dacarbazine
Dacarbazine, also known as DTIC, is an intravenous alkylating chemotherapy drug of the triazene class, FDA approved in 1975 and used to treat metastatic melanoma and Hodgkin lymphoma, including as part of the ABVD regimen.
Daclatasvir
Daclatasvir (Daklinza) is a first-in-class Bristol-Myers Squibb NS5A inhibitor for chronic hepatitis C, used with sofosbuvir; EU approval 2014, withdrawn 2019 commercially, now generic via the Medicines Patent Pool in 112 countries.
Daclizumab
Daclizumab (Zenapax, Zinbryta): humanized anti-CD25 IgG1 antibody blocking the high-affinity IL-2 receptor; first FDA-approved humanized mAb (1997, transplant rejection), later a relapsing MS therapy withdrawn worldwide in March 2018 for liver and brain immune injuries.
Dacryocystitis
Dacryocystitis, inflammation or infection of the lacrimal sac (tear sac), usually from nasolacrimal duct obstruction. Acute and chronic forms; treated with antibiotics and dacryocystorhinostomy; congenital cases often resolve by age one.
Dacryocystography
Dacryocystography (DCG) is a radiographic technique that injects iodinated contrast into a tear duct canaliculus to image the lacrimal drainage system and locate the site of obstruction in patients with overflowing tears.
Dacryocystorhinostomy
Dacryocystorhinostomy (DCR) is eye surgery that creates a new path for tears to drain between the eyes and the nose when the tear duct is blocked, treating epiphora and dacryocystitis.
Dacryolith
Dacryolith (tear stone, 涙石): a concretion of the lacrimal drainage system, ICD-11 9A11.6, found in 6-18% of DCR patients, composed mainly of proteins, mucins, and TFF peptides, treated by extraction.
Dactolisib
Dactolisib (BEZ235, NVP-BEZ235) is an oral imidazoquinoline dual PI3K/mTOR inhibitor developed by Novartis; the first such agent in trials, discontinued for toxicity and limited efficacy, distinct from gedatolisib.
Dadhika ghrta
Dadhika ghrta (Dādhika ghṛta), a classical Ayurvedic medicated ghee with curd four times the ghee's weight, defined in Sushruta Samhita for gulma; AFI000421, 12 g dose, about 60 ingredients.
Dadimadi ghrta
Dadimadi ghrta (Dāḍimādi Ghṛta, दादिमादी घृत) is a classical Ayurvedic medicated ghee of pomegranate, coriander, citraka, ginger, and pippali in cow ghee, standardized in the API and used mainly for anemia (Pandu) and pregnancy-related conditions.
Dadimastaka Curna
Dadimastaka Curna (Dāḍimāṣṭaka cūrṇa), an Ayurvedic pomegranate-based polyherbal powder (AFI000549, dose 5–10 g) used for diarrhea, indigestion, and perinatal care; standardized by HPLC/HPTLC markers.
Daehan Hospital
Daehan Hospital (대한의원) was the state hospital of the Korean Empire, established in 1907 and opened in 1908; its main building in Seoul is now a designated Historic Site.
Daflon
Daflon 500 mg (micronized purified flavonoid fraction, MPFF; diosmin 450 mg plus hesperidin 50 mg) is a Servier venoactive drug for chronic venous insufficiency and hemorrhoids, widely prescribed in Europe but not available in the USA.
DAI trial
DAI trial (NCT05471180), a withdrawn randomized double-blind Brazilian trial testing 660 nm diode laser photobiomodulation plus protective spray film versus sham for incontinence-associated dermatitis in 78 hospitalized adults.
Dalantercept
Dalantercept (ACE-041), an Acceleron Pharma soluble ALK1-Fc ligand trap blocking BMP9/BMP10 angiogenesis signaling, was tested with axitinib in renal cell carcinoma but discontinued in 2017 after its phase 2 DART trial showed no PFS benefit.
Dalbavancin
Dalbavancin, marketed as Dalvance and Xydalba, is a long-acting lipoglycopeptide antibiotic for acute bacterial skin infections, including MRSA, given as one or two weekly infusions.
Dalcetrapib
Dalcetrapib (RO4607381, JTT-705) is a CETP modulator that raises HDL cholesterol about 30% with minimal LDL effect; its phase 3 dal-OUTCOMES trial failed for futility, and development continues only for ADCY9 AA-genotype patients.