25,729 articles
Dalfampridine
Dalfampridine (fampridine, 4-aminopyridine; brands Ampyra, Fampyra) is an extended-release potassium channel blocker improving walking in MS (EDSS 4-7); 10 mg twice daily, about one third of patients respond with ~25% speed gain; seizure and renal-impairment contraindications.
Dalfopristin
Dalfopristin, a semi-synthetic streptogramin A antibiotic derived from pristinamycin IIA, forms the 70:30 intravenous combination Synercid with quinupristin; FDA-approved in 1999 for vancomycin-resistant E. faecium and later discontinued in the US.
Dalnacogene ponparvovec injection
Dalnacogene ponparvovec injection (BBM-H901, brand name Xinjuning) is a one-time gene therapy for moderate-to-severe hemophilia B in adults, first approved in China on April 10, 2025.
Dalpiciclib
Dalpiciclib (SHR6390) is an oral CDK4/6 inhibitor from Hengrui Pharmaceuticals, approved in China in 2021, used with endocrine therapy for HR-positive/HER2-negative breast cancer; key trials include DAWNA-1, DAWNA-2, and the adjuvant DAWNA-A, with neutropenia as its characteristic toxicity.
Dalteparin sodium
Dalteparin sodium (Fragmin) is a low-molecular-weight heparin anticoagulant approved in the US in 1994, dosed by weight subcutaneously; it treats cancer-associated VTE, provides surgical and medical thromboprophylaxis, and covers unstable angina and dialysis circuits.
Dalzanemdor
Dalzanemdor (SAGE-718) is an investigational oral NMDA receptor positive allosteric modulator by Sage Therapeutics for cognitive impairment in Huntington's, Alzheimer's, and Parkinson's disease; all phase 2 trials missed endpoints and development was discontinued in 2024.
Damage control resuscitation
Damage control resuscitation (DCR) is a trauma care strategy for severely bleeding patients that combines permissive hypotension, 1:1:1 blood product transfusion, and rapid surgical hemorrhage control.
Damage control surgery
Damage control surgery (DCS) is a staged approach to major trauma in which an abbreviated first operation controls bleeding and contamination, ICU resuscitation restores physiology, and a planned reoperation performs definitive repair.
Dan G. McNamara
Dan G. McNamara (1922–1998) was an American pediatric cardiologist who founded Houston's first pediatric heart program at Texas Children's Hospital and Baylor College of Medicine.
DANAMI-3 trial
DANAMI-3 (Third Danish Study of Optimal Acute Treatment of Patients With STEMI), a Danish program of three randomized trials (iPOST, DEFER, PRIMULTI) at 4 centers, 2011-2014, testing postconditioning, deferred stenting, and complete revascularization in STEMI.
Danaparoid sodium
Danaparoid sodium (Orgaran) is a non-heparin heparinoid mixture of glycosaminoglycans from porcine mucosa, an antithrombin-mediated factor Xa inhibitor (anti-Xa:anti-IIa 22:1) used for HIT treatment and DVT prophylaxis; withdrawn from the US in 2002.
Danazol
Danazol: synthetic androgenic steroid derived from ethisterone, approved 1976 for endometriosis pain; suppresses pituitary-ovarian axis, binds androgen/progesterone/glucocorticoid receptors; now largely abandoned due to androgenic side effects.
Dance movement therapy
Dance movement therapy (DMT) is a psychotherapy using dance and movement to integrate emotional, cognitive, social, and physical health, practiced by trained therapists in mental health and rehabilitation settings.
Dance On 50+ trial
Dance On 50+ (NCT07158866) is a Universidade do Porto clinical trial comparing ballroom dance, multicomponent exercise, and no intervention in 110 healthy adults aged 50+ over 6 months.
Dance Therapy
Dance therapy (dance/movement therapy, DMT; UK: dance movement psychotherapy) is the psychotherapeutic use of dance and movement for healing, pioneered by Marian Chace in 1940s America, with the ADTA founded in 1966 and meta-analyses showing moderate psychological benefits.
Dandruff
Dandruff, the mild scalp end of seborrheic dermatitis, causes flaky, itchy scalp skin; linked to Malassezia yeast, sebum, and skin barrier dysfunction; treated with medicated shampoos.
Danegaptide
Danegaptide (ZP1609, GAP-134) is a rotigaptide-derived dipeptide gap junction modifier acting on connexin 43. Its phase 2 STEMI reperfusion-injury trial failed, and it is now in diabetic retinopathy development by Breye Therapeutics.
Danger triangle of the face
The danger triangle of the face, also called the nasolabial triangle, spans from the nose bridge to the mouth corners, where infections can spread to the brain.
Danggui San
当归散 (Danggui San, Danggui Powder), also called Antai Wan, is a five-herb classic Chinese medicine formula from Zhang Zhongjing's Jingui Yaolue, used to nourish blood, clear damp-heat, and calm the fetus, now studied mainly for recurrent miscarriage.
Danggui Yinzi
Danggui Yinzi (当归饮子) is a classic Chinese herbal formula for itching and skin disease, first recorded in 1253 and now used for urticaria, pruritus, and eczema.
Danicopan
Danicopan (Voydeya, ALXN2040) is an oral complement factor D inhibitor approved in 2024 as add-on to ravulizumab or eculizumab for extravascular hemolysis in adults with paroxysmal nocturnal hemoglobinuria, based on the phase 3 ALPHA trial.
Daniel Amen
Daniel Gregory Amen, born 1954, is an American psychiatrist, author, and media personality who founded Amen Clinics, a chain using SPECT brain scans to diagnose psychiatric conditions.
Daniel David Palmer
Daniel David Palmer (D.D. Palmer, 1845-1913), Canadian-American magnetic healer who founded chiropractic in Davenport, Iowa; performed the first adjustment on Harvey Lillard on September 18, 1895, coined the term chiropractic, and opened the first chiropractic school in 1897.
Daniel Hale Williams
Daniel Hale Williams (1856–1931), American surgeon, founded Chicago's interracial Provident Hospital in 1891, sutured James Cornish's pericardium after a heart stab wound in 1893, co-founded the National Medical Association, and was the first Black Fellow of the American College of Surgeons.
Daniel L. Azarnoff
Daniel L. Azarnoff is an American physician and clinical pharmacologist, elected to the Institute of Medicine in 1978, who led drug research at the University of Kansas and Searle.
Daniel Matthew Ammon
Daniel Matthew Ammon is an American biomaterials scientist and medical-device R&D executive, Vice President of R&D at Becton Dickinson, elected to the National Academy of Engineering in 2023 for medical-device technologies.
Daniel Paul Schreber
Daniel Paul Schreber (1842–1911), German Senatspräsident at Dresden, author of Denkwürdigkeiten eines Nervenkranken (1903), the most cited psychiatric patient, subject of Freud's 1911 paranoia essay and Lacan's Seminar III.
Daniel Samuel Pine
Daniel Samuel Pine is an American psychiatrist and NIH Distinguished Investigator who leads NIMH's Section on Development and Affective Neuroscience, studying brain mechanisms of pediatric anxiety and mood disorders.
Daniel Tassin
Daniel Tassin is a French bridge engineer specializing in precast segmental and cable-stayed concrete bridges, co-founder of International Bridge Technologies and a 2018 National Academy of Engineering member.
DANISH trial
DANISH (Danish Study to Assess the Efficacy of ICDs in Non-ischemic Systolic Heart Failure on Mortality), 2016 NEJM randomized trial of 1,116 patients: prophylactic ICD did not reduce all-cause mortality but halved sudden cardiac death.