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Human health and medicine

25,729 articles

Docetaxel/gemcitabine regimen

The docetaxel/gemcitabine regimen, also called docetaxel and gemcitabine, is a doublet chemotherapy combination pairing a taxane with an antimetabolite, best documented for soft-tissue sarcoma, especially leiomyosarcoma.

Dociparstat sodium

Dociparstat sodium (ODSH, DSTAT, CX-01) is a non-anticoagulant 2-O,3-O-desulfated heparin derivative inhibiting CXCL12/CXCR4, RAGE, and heparanase; investigated in AML, MDS, and COVID-19, with development stopped by Chimerix.

Doctor Mike (Михаил Варшавский)

Doctor Mike, Mikhail Varshavski (Михаил Варшавский), is a Russian-born American board-certified family medicine physician and the most-followed doctor on social media, with over 30 million followers, a YouTube channel launched in 2017, and The Checkup podcast.

Doctor of Medicine

The Doctor of Medicine (MD or M.D.) is a professional doctoral degree in medicine granted in the United States and Canada after four years of accredited study.

Doctor of Osteopathic Medicine

Doctor of Osteopathic Medicine (DO), a US physician degree from COCA-accredited colleges founded on A.T. Still's 1874 philosophy; DOs are fully licensed physicians with OMT training, COMLEX licensure, and outcomes matching MDs.

Doctor of Pharmacy

Doctor of Pharmacy (PharmD): the six-year entry-level professional doctorate for US pharmacists since 2000, ACPE-accredited under Standards 2025, with IPPE/APPE rotations and NAPLEX licensure; distinct from the PhD and adopted in countries such as Thailand and Japan.

Docusate

Docusate (Dulcoease, Dioctyl, Colace) is an anionic surfactant stool softener laxative for constipation, given orally or as an enema; trials show it is no more effective than placebo and inferior to psyllium.

Dofetilide

Dofetilide, sold as Tikosyn, is a Class III antiarrhythmic drug that blocks a cardiac potassium current to convert atrial fibrillation and must be started in hospital under monitoring.

Dog skin disorders

Dog skin disorders: inflammatory, allergic, parasitic, and infectious skin diseases in dogs, among the most common reasons for veterinary visits; includes atopic dermatitis, flea and food allergy, pyoderma, and their diagnosis and treatment.

Dolasetron

Dolasetron (Anzemet), a pseudopelletierine-derived 5-HT3 antagonist antiemetic converted to hydrodolasetron, approved 1997; oral form remains for CINV prevention, IV withdrawn over QTc prolongation.

Dolomite as a mineral source

Dolomite (CaMg(CO3)2, CAS 16389-88-1) as a mineral source of calcium and magnesium: GRAS Notice 806 for bottled-water remineralization at 40 mg/L Ca and 25 mg/L Mg, versus supplement-grade dolomite with heavy-metal contamination concerns.

DOMINO trial

DOMINO (Doxycycline versus Macrolides for Mycoplasma pneumoniae INfectiOn in Children) is a planned South Korean multicentre randomised trial, NCT07306234, testing first-line doxycycline versus azithromycin in 208 children aged 3–17 with suspected macrolide-resistant M. pneumoniae pneumonia.

Domperidone

Domperidone (Motilium) is a peripheral dopamine D2 antagonist antiemetic and prokinetic, synthesized 1974, marketed 1982; unapproved in the US, EU-restricted to 30 mg/day for nausea and vomiting over cardiac QT risks.

Domvanalimab

Domvanalimab (AB154) is an Fc-silent humanized IgG1 anti-TIGIT monoclonal antibody from Arcus/Gilead, tested with zimberelimab in NSCLC and gastroesophageal cancers; phase 3 STAR-221 and STAR-121 were discontinued for futility.

Donafenib tosylate

Donafenib tosylate (甲苯磺酸多纳非尼片, Zepsun) is a Chinese-approved oral multi-kinase inhibitor related to sorafenib; first-line therapy for unresectable hepatocellular carcinoma and radioactive iodine-refractory differentiated thyroid cancer.

Donald A. Henderson

Donald A. Henderson (1928–2016) was an American physician who directed the WHO smallpox eradication program from 1966 to 1977, then served as dean at Johns Hopkins.

Donald A.B. Lindberg

Donald A.B. Lindberg (1933–2019) was an American physician and pathologist who led the U.S. National Library of Medicine for over 30 years, launching PubMed and MedlinePlus.

Donald E. Wilson

Donald E. Wilson is an American gastroenterologist and academic administrator, the thirtieth dean of the University of Maryland School of Medicine from 1991 to 2006.

Donald Ewen Cameron

Donald Ewen Cameron (1901–1967), Scottish-Canadian psychiatrist, founded McGill's psychiatry department and the Allan Memorial Institute, led the CIA-funded MK Ultra Subproject 68 "psychic driving" and "depatterning" experiments in Montreal, and headed the American and World Psychiatric Associations.

Donald J. Galagan

Donald J. Galagan was an American dental public health leader who rose to Assistant Surgeon General in the U.S. Public Health Service and helped establish water fluoridation.

Donald Triplett

Donald Gray Triplett (1933-2023), Forest, Mississippi banker known as 'Case 1, Donald T.', the first person formally diagnosed with autism in Leo Kanner's 1943 paper; worked 65 years at a bank, traveled widely, died at 89.

Donanemab

Donanemab (Kisunla, donanemab-azbt) is Eli Lilly's anti-amyloid monoclonal antibody for early symptomatic Alzheimer's disease, FDA-approved July 2, 2024; given monthly by IV with limited-duration dosing, it slows decline by about a third but carries a boxed warning for ARIA.

Donaperminogene seltoplasmid

Donaperminogene seltoplasmid (VM202, Engensis, PCK-HGFX7) is a naked plasmid DNA gene therapy encoding two hepatocyte growth factor isoforms, injected intramuscularly; developed by ViroMed/Helixmith, tested in diabetic neuropathy and CLTI, approved in China as Huasuoling in 2026.

Donath–Landsteiner hemolytic anemia

Donath–Landsteiner hemolytic anemia, or paroxysmal cold hemoglobinuria (PCH), is a rare autoimmune hemolytic anemia caused by a biphasic IgG anti-P antibody that binds red cells in the cold and lyses them via complement on rewarming; today mostly a postinfectious pediatric disease diagnosed by the Donath–Landsteiner test.

Donepezil

Donepezil, sold as Aricept, is a reversible acetylcholinesterase inhibitor used to treat dementia in mild, moderate, and severe Alzheimer's disease. Developed by Eisai and approved in 1996, it eases symptoms but does not slow the disease.

Dongui Bogam

Dongui Bogam (동의보감) is a Korean medical encyclopedia compiled by court physician Heo Jun, completed in 1610 and listed on UNESCO's Memory of the World Register.

Dongyuan Shixiao Fang

Dongyuan Shixiao Fang (东垣试效方, Proven Formulas of Dongyuan), a nine-juan Chinese formulary by Jin dynasty physician Li Gao (李杲), compiled by disciple Luo Tianyi, completed 1266; 20 essays, 240+ formulas, source of Puji Xiaodu Yin.

Donislecel

Donislecel, marketed as Lantidra, is a pancreatic islet cell therapy approved by the FDA in June 2023 for adults with type 1 diabetes and repeated severe hypoglycemia.

Donna Diers

Donna Kaye Diers (1938–2013) was an American nurse, researcher, and educator who spent over 40 years at Yale School of Nursing, serving as its sixth dean.

Donnai-Barrow syndrome

Donnai-Barrow syndrome (DBS, FOAR syndrome, OMIM 222448) is an ultra-rare autosomal recessive disorder caused by LRP2 (megalin) variants, marked by hearing loss, high myopia, agenesis of the corpus callosum, and low-molecular-weight proteinuria.