25,729 articles
ICSI study
ICSI (Pilot Italian Cardiogenic Shock Initiative, NCT06475456) is a Fondazione GISE observational study testing a SCAI-based spoke-hub cardiogenic shock protocol in Turin and Milan, comparing 30-day mortality in 768 AMICS patients across retrospective and prospective cohorts in 16 centers.
Icteric sclera
Icteric sclera (scleral icterus, more accurately conjunctival icterus) is yellowing of the eye whites from excess bilirubin, appearing at roughly 2 to 3 mg/dL, an early sign of liver, biliary, or blood disease.
ICU-RESUS trial
ICU-RESUS (NCT02837497), a hybrid stepped-wedge cluster randomized trial in 18 US pediatric ICUs, 2016–2021, tested point-of-care CPR training plus debriefing; it did not significantly improve favorable neurologic survival (53.8% vs 52.4%).
Ida Spruill
Ida J. Spruill was an American nurse-scientist at the Medical University of South Carolina who led genetic and health-disparities research with the Gullah people of the Sea Islands.
Idalopirdine
Idalopirdine (Lu AE58054, SGS518, LY483518) is a selective 5-HT6 receptor antagonist developed by Lundbeck with Otsuka for Alzheimer's disease; positive phase 2 but failed phase 3 STAR trials, rights licensed to Denovo Biopharma in 2021.
Idarucizumab
Idarucizumab (Praxbind) is a humanized monoclonal antibody fragment by Boehringer Ingelheim that reverses dabigatran anticoagulation; US approval October 2015, 5 g IV dose, rebound risk in renal impairment.
Idasanutlin
Idasanutlin (RG7388, RO5503781) is an oral Roche small-molecule MDM2 antagonist that restores p53 activity; its phase 3 MIRROS AML trial missed overall survival and development was closed in 2024.
Ideal Body Weight
Ideal body weight (IBW) is a height-based weight estimate from Metropolitan Life Insurance tables and formulas such as Devine (1974), Hamwi, Robinson, and Miller, used clinically for drug dosing, nutrition, and ventilation, with adjusted body weight variants for obesity.
IDEAL trial (NCT03511482)
IDEAL (NCT03511482), Integrated Digitally Enhanced Care for Long-term Conditions-Asthma, a withdrawn UK feasibility trial of the myAsthma app with Lloyds Pharmacy Online Doctor remote consultations in primary care; stopped for lack of funding before results.
IDEAL trial (NCT06590545)
IDEAL (NCT06590545) is a phase 1/2 trial of anti-CD19 CAR-T therapy (KYV-101, mivocabtagene autoleucel) for 8 treatment-refractory, ANCA-IgG-positive ANCA-associated vasculitis patients at Charité Berlin, funded by Kyverna Therapeutics.
IDEATel trial
The IDEATel trial was a randomized controlled trial of telemedicine case management versus usual care in 1,665 older Medicare beneficiaries with diabetes in New York State.
Idebenone
Idebenone (Raxone) is a synthetic short-chain benzoquinone, a non-natural CoQ10 analogue developed by Takeda, acting as a mitochondrial electron carrier bypassing complex I; EU-approved for LHON, investigated in Friedreich ataxia, DMD, and Alzheimer's disease.
Idecabtagene vicleucel
Idecabtagene vicleucel (ide-cel, BB2121, Abecma) is an autologous anti-BCMA CAR T-cell therapy for relapsed/refractory multiple myeloma; FDA approved March 2021, KarMMa ORR 73%.
Idelalisib
Idelalisib (Zydelig) is an oral PI3Kδ inhibitor, the first approved PI3K inhibitor, used with rituximab in relapsed CLL; its FL and SLL indications were withdrawn in 2022 over safety and poor confirmatory enrollment.
Identity disturbance
Identity disturbance: markedly and persistently unstable self-image or sense of self, a DSM-5 criterion of borderline personality disorder, rooted in Erikson's identity diffusion and Kernberg's identity diffusion construct, central to ICD-11 personality pathology severity.
Idiopathic acute eosinophilic pneumonia
Idiopathic acute eosinophilic pneumonia (IAEP) is a rare eosinophilic lung disease, first described in 1989, causing acute febrile hypoxic respiratory failure with BAL eosinophilia over 25% in previously healthy people; corticosteroids usually cure it.
Idiopathic angioedema
Idiopathic angioedema (chronic idiopathic angioedema) is recurrent deep-skin or submucosal swelling with no identifiable cause, diagnosed by exclusion. Subtypes are histaminergic and non-histaminergic; most cases respond to H1-antihistamines, corticosteroids, or epinephrine.
Idiopathic aplastic anemia
Idiopathic aplastic anemia (idiopathic bone marrow failure, ICD-10 D61.3) is a rare bone marrow failure disorder with pancytopenia and no identifiable cause; it accounts for 70-80% of aplastic anemia cases and is treated with immunosuppressive therapy or stem cell transplant.
Idiopathic aseptic osteonecrosis
Idiopathic aseptic osteonecrosis (ICD-11 FB81.0; ICD-10 M87.0) is bone death from lost blood supply with no identifiable cause, up to 40% of cases, mainly femoral head in adults aged 33-45, diagnosed by MRI.
Idiopathic avascular necrosis
Idiopathic avascular necrosis (idiopathic AVN, osteonecrosis) is rare bone death from disrupted blood supply with no known cause, affecting the femoral head, talus, humerus, and scaphoid, causing refractory pain and possible bone collapse.
Idiopathic bilateral vestibulopathy
Idiopathic bilateral vestibulopathy (IBV, ORPHA 171684) is an acquired bilateral peripheral vestibular dysfunction of unknown cause, with persistent unsteadiness and oscillopsia but no hearing loss beyond age-related; first defined by Baloh et al. in 1989.
Idiopathic bronchiectasis
Idiopathic bronchiectasis is bronchiectasis, a chronic respiratory disease of permanently widened airways causing daily cough and sputum, with no identifiable cause after systematic testing; it is the largest category of non-cystic fibrosis bronchiectasis in adults.
Idiopathic camptocormia
Idiopathic camptocormia (bent spine syndrome) is a rare postural disorder with involuntary forward trunk flexion when standing or walking that resolves supine, caused by fatty-infiltrated, weak lumbar paraspinal muscles with no identifiable cause.
Idiopathic catatonia
Idiopathic catatonia, also called isolated catatonia or idiopathic catatonic syndrome, is a rare condition marked by catatonic features without any psychiatric, medical, or substance cause.
Idiopathic CD4 lymphocytopenia
Idiopathic CD4 lymphocytopenia (ICL), also called idiopathic CD4+ T-lymphocytopenia, is a rare immunodeficiency defined by CD4 counts below 300 cells/mm3 without HIV, causing opportunistic infections, cancer risk, and sometimes spontaneous recovery.
Idiopathic central alveolar hypoventilation
Idiopathic central alveolar hypoventilation (ICAH, ICD-11 7A42.3), also called sleep-related idiopathic or non-obstructive alveolar hypoventilation, is a sleep-related breathing disorder with hypercapnia and hypoxemia from blunted CO2/O2 chemoresponsiveness, diagnosed by polysomnography with CO2 monitoring after excluding other causes.
Idiopathic chronic eosinophilic pneumonia
Idiopathic chronic eosinophilic pneumonia (ICEP, CEP, cryptogenic pulmonary eosinophilia) is a rare interstitial lung disease with lung eosinophil accumulation, asthma association, rapid steroid response, and frequent relapse.
Idiopathic chronic pancreatitis
Idiopathic chronic pancreatitis (ICP) is chronic pancreatitis with no identified cause after full workup, up to 25% of cases, divided into early-onset (median onset ~20 years) and late-onset (~58 years) forms with strong SPINK1, CFTR, and CTRC genetic susceptibility.
Idiopathic dropped head syndrome
Idiopathic dropped head syndrome, also known as isolated neck extensor myopathy, is an uncommon muscle disorder in which weak neck extensors leave the head unable to stay erect.
Idiopathic ductopenia
Idiopathic ductopenia (idiopathic adulthood ductopenia, IAD) is a rare cholestatic liver disease with unexplained loss of interlobular bile ducts in over 50% of portal tracts, first described by Ludwig in 1988, affecting young adults and sometimes requiring transplantation.