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Human health and medicine

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KUTAJARISTA

Kutajarista (Kutajarishta) is a classical Ayurvedic fermented polyherbal arishta based on Holarrhena antidysenterica bark, started with Woodfordia fruticosa flowers, used for diarrhea, dysentery, and grahani; standardized by conessine markers.

Kutajastaka kvatha curna

Kutajastaka kvatha curna (Kuṭajāṣṭaka kvātha cūrṇa), AFI formulation AFI000512, an eight-ingredient Ayurvedic coarse-powder decoction led by Holarrhena pubescens bark, dosed 48 g/day, indicated for diarrhea, pain, and related conditions.

Kutajavaleha

Kutajavaleha (Kutaj Avaleha), a classical Ayurvedic semisolid avaleha electuary whose main ingredient is Holarrhena antidysenterica bark, used for diarrhea, dysentery, Grahani/IBS, and hemorrhoids; AFI dose 6-12 g.

Kutajghanaka rasayana

Kutajghanaka rasayana, or Kutajaghana vati (कुटजघनवटी), is a classical Ayurvedic tablet made from concentrated Kutaja bark extract and Ativisha root, prescribed for diarrhea, grahani, and fever.

Kuzambu

Kuzambu (kuzhambu), Elanīr kuzambu (nālikerāñjana), Ayurvedic collyrium AFI000179 applied to internal eyelids; ten ingredients including triphala fruits, Berberis aristata, licorice, honey, and coconut water; Kerala Sneha Kalpana form.

Kveim Test

Kveim test, or Kveim-Siltzbach test, an intradermal skin test for sarcoidosis using heat-treated sarcoid tissue suspension; a granulomatous nodule at the injection site, read histologically after 4 to 6 weeks, indicates active sarcoidosis.

Kwashiorkor

Kwashiorkor is the edematous form of severe acute malnutrition, marked by pitting swelling in children around weaning; the name, from Ghana's Kwa language, means "the sickness of the weaning."

Kylo-11

Kylo-11 (LPA siRNA, MVIP platform, Hygieia/Sino Biopharmaceutical) is a non-canonical dual-GalNAc siRNA lowering lipoprotein(a); phase 1 showed up to 97% reduction at 48 weeks after one dose, phase 2 ongoing.

Kymography

Kymography (kymograph, "wave writer") records wavelike motions over time; invented by Carl Ludwig in 1846/47 with a smoked drum and mercury manometer for blood pressure, now a digital live-cell imaging analysis method.

KYO-1

KYO-1 (KYO1, Kyoto 1; CVCL_2095, DSMZ ACC 601) is a human Philadelphia chromosome-positive CML blast crisis cell line established in 1981 from a 22-year-old Japanese man's peripheral blood, carrying BCR-ABL1 b2a2 and a homozygous TP53 p.Arg248Gln mutation.

Kyphomelic dysplasia

Kyphomelic dysplasia (KMD, OMIM 211350) is a rare bent-bone skeletal dysplasia with severely angulated femurs, short stature, narrow thorax, and platyspondyly; classically autosomal recessive, now linked to biallelic CCN2 and de novo KIF5B variants.

Kyphoplasty

Kyphoplasty is a minimally invasive procedure in which a balloon is inflated inside a fractured vertebra to restore height before bone cement is injected, treating painful compression fractures.

Kyphoscoliotic Ehlers-Danlos syndrome

Kyphoscoliotic Ehlers-Danlos syndrome (kEDS, EDS type VI), autosomal recessive, PLOD1 or FKBP14 subtypes: congenital muscle hypotonia, congenital kyphoscoliosis, joint hypermobility, dislocations, hearing loss, and rare vascular complications.

Kyphosis

Kyphosis (hyperkyphosis, roundback, hunchback) is excessive forward curvature of the spine, mainly thoracic. Types include postural, Scheuermann's (≥5° wedging at 3 vertebrae), congenital, and age-related; treated with exercise, bracing, or fusion surgery.

L-1236

L-1236 (L1236, CVCL_2096, DSMZ ACC-530) is a human classical Hodgkin lymphoma cell line established in 1994 from the peripheral blood of a 34-year-old man, with proven Hodgkin/Reed-Sternberg origin, TNFAIP3 and TP53 lesions, and a published STR and HLA profile.

L-2-hydroxyglutaric aciduria

L-2-hydroxyglutaric aciduria (L-2-HGA, OMIM 236792) is a rare autosomal recessive neurometabolic disorder caused by L2HGDH deficiency, causing L-2-hydroxyglutarate accumulation, progressive cerebellar ataxia, epilepsy, macrocephaly, and increased brain tumor risk.

L-428

L-428 (L428) is a human cell line derived from Hodgkin and Reed-Sternberg cells, established in 1978 in Hanover, Germany, as the first permanently growing Hodgkin lymphoma cell line.

L-591

L-591 (CVCL_1867, DSMZ ACC-602) is a human Hodgkin lymphoma cell line established in 1982 from a 31-year-old woman's pleural effusion; the only EBV-positive HL line, with latency 3 EBV expression and controversial HRS-cell origin.

L-Arginine:glycine amidinotransferase deficiency

AGAT deficiency (GATM, OMIM 612718), an ultrarare autosomal recessive creatine biosynthesis disorder with under 20 reported cases, causing developmental delay, intellectual disability, myopathy, low guanidinoacetate, and treatable with creatine monohydrate.

L-carnitine L-tartrate

L-carnitine L-tartrate (LCLT), also called levocarnitine tartrate, is the tartrate salt of L-carnitine used as a dietary supplement and infant-formula ingredient; GRAS-notified (GRN 993) and bioequivalent to free L-carnitine.

L-DOPA

L-DOPA (levodopa), the dopamine precursor crossing the blood-brain barrier, is the standard Parkinson's disease drug; isolated from Vicia faba in 1910-13, clinically established by Carlsson, Hornykiewicz, and Cotzias's 1967 high-dose oral regimen.

L-ferritin deficiency

L-ferritin deficiency (ORPHA:440731, OMIM 615604) is a rare FTL-gene iron-metabolism disorder with undetectable serum L-ferritin but normal iron parameters, causing seizures, atypical restless legs, and hair loss.

L-Methylfolate (calcium salt)

Calcium L-methylfolate, also called levomefolate calcium or Metafolin, is the calcium salt of L-5-methyltetrahydrofolate, the predominant natural form of folate, used in supplements and fortified foods.

L-type calcium channel

L-type calcium channels (Cav1.1–Cav1.4) are high-voltage-activated, dihydropyridine-sensitive voltage-gated calcium channels in muscle, heart, and neurons; Cav1.2 drives cardiac excitation-contraction coupling, and their blockers treat hypertension and angina.

L. Thompson Bowles

L. Thompson Bowles is an American thoracic surgeon and academic medicine leader who was dean of the George Washington University School of Medicine from 1976 to 1988.

L'Encéphale

L'Encéphale is a French-language bimonthly psychiatry journal founded in Paris in 1906 by Antheaume and Klippel, published by Elsevier Masson, ISSN 0013-7006, indexed in MEDLINE since 1964.

L1 syndrome

L1 syndrome (CRASH syndrome, L1CAM syndrome): X-linked recessive neurodevelopmental disorder from L1CAM mutations, causing hydrocephalus, intellectual disability, leg spasticity, and adducted thumbs; HSAS form affects about 1 in 30,000 males.

La Crosse encephalitis

La Crosse encephalitis, caused by La Crosse virus (LACV), a California serogroup orthobunyavirus spread by Aedes triseriatus mosquitoes, is the leading pediatric arboviral encephalitis in the United States, affecting mainly children under 16 with seizures and, rarely, fatal outcomes.

La petite mort

La petite mort, French for "the little death," is a literary euphemism for orgasm and the post-orgasm state; covers its 16th-century medical origin, Balzac, dictionary history, and postcoital dysphoria research.

La revue du praticien

La Revue du Praticien (Revue du praticien) is a French continuing medical education journal founded in Paris in 1951, published monthly by Global Média Santé in two titles including Médecine Générale, MEDLINE-indexed since 1972.