25,729 articles
Ligation
Ligation is a surgical technique in which a suture, thread, or band is tied around a blood vessel or duct to stop bleeding or close the structure off.
Ligelizumab
Ligelizumab (QGE031), Novartis' humanized anti-IgE monoclonal antibody successor to omalizumab, binds IgE about 88-fold more tightly, beat placebo but not omalizumab in phase 3 CSU trials, and was discontinued in 2023-2024.
Light chain deposition disease
Light chain deposition disease (LCDD) is a clonal plasma cell disorder with non-amyloid kappa-predominant monoclonal light chain deposits, mainly in kidneys; a form of MIDD described by Randall in 1976, treated with bortezomib and ASCT.
Light Coagulation
Light coagulation (photocoagulation, German Lichtkoagulation) is thermal treatment of tissue, chiefly the retina, with intense light or laser; pioneered by Meyer-Schwickerath in 1949 and proven by the DRS and ETDRS for diabetic eye disease.
Light dosimetry
Light dosimetry is the measurement and calculation of light energy delivered to tissue during photodynamic therapy, used to plan treatments and verify the dose received.
Light menstrual bleeding
Light menstrual bleeding, or hypomenorrhea (scanty menses), is abnormally light menstrual flow, defined in ICD-11 as under 5 ml monthly blood loss; causes include hormonal factors, PCOS, perimenopause, thyroid disease, and endometrial damage.
Light therapy
Light therapy: controlled exposure to bright white/blue light, red-near-infrared photobiomodulation, or UV phototherapy for SAD, depression, circadian disorders, skin disease, and tissue repair; standard dose 10,000 lux for 30 minutes each morning.
LIGHT trial
LIGHT trial (NCT07325539): Phase II, open-label, single-arm study at Sun Yat-sen University testing low-dose radiotherapy (0.5 Gy x 4 fractions per cycle) added to toripalimab plus gemcitabine-cisplatin for recurrent/metastatic nasopharyngeal carcinoma; 55 participants, primary endpoint PFS by RECIST 1.1.
Light-Curing of Dental Adhesives
Light-curing of dental adhesives: photopolymerization of resin bonding materials using dental light-curing units (QTH, LED, plasma arc), camphorquinone photoinitiators at ~465 nm, radiant exposure, and blue-light safety.
Lightheadedness
Lightheadedness, also called light-headedness or presyncopal dizziness, is a vague faint or floating sensation, one of four dizziness types, caused by reduced cerebral blood flow (orthostatic hypotension, arrhythmia), hyperventilation, anxiety, or medications.
Ligufalimab
Ligufalimab (莱法利, AK117) is Akeso's humanized IgG4 anti-CD47 monoclonal antibody that blocks CD47–SIRPα "don't eat me" signaling; its lateral binding orientation avoids RBC hemagglutination, removing the need for a priming dose, with phase 1b AML/MDS and phase III solid tumor studies.
Likangkopan fumarate
Likangkopan fumarate (富马酸立康可泮, HRS-5965, brand Hengyouda) is Hengrui's oral complement factor B inhibitor approved in China in August 2026 for complement inhibitor-naive adults with PNH, superior to eculizumab in phase 3.
Lila Vilasa Rasa
Lila Vilasa Rasa (Līlāvilāsa rasa, AFI000445) is a classical Ayurvedic herbo-mineral rasa medicine with purified mercury, sulphur, calcined copper and mica plus triphala fruits, dosed 250-500 mg, used for amlapitta (acidity).
Lillian Gelberg
Lillian Gelberg is an American family physician and health services researcher, professor of family medicine at UCLA, known for the Behavioral Model for Vulnerable Populations and elected to the National Academy of Medicine in 2003.
Limaprost
Limaprost (Opalmon, Prorenal) is an oral prostaglandin E1 analogue developed by Ono and Dainippon Sumitomo in Japan, approved 1988 for thromboangiitis obliterans and 2001 for lumbar spinal stenosis, dosed 15-30 micrograms daily.
Limb (anatomy)
Limb (anatomy): paired upper and lower human appendages of the appendicular skeleton, 30 bones each, attached by pectoral and pelvic girdles; upper limb for mobility, lower for weight bearing.
Limb body wall complex
Limb body wall complex (LBWC), also called body stalk anomaly, is a rare lethal fetal malformation syndrome with body wall defects, limb defects, and often craniofacial anomalies; diagnosis follows Van Allen's two-of-three criteria, etiology is unknown, and prevalence estimates range widely.
Limb overgrowth
Limb overgrowth, ICD-11 LB97, is abnormal enlargement of a limb or digit seen in macrodactyly, hemihyperplasia, Klippel-Trenaunay syndrome, and PIK3CA-related overgrowth spectrum (PROS), caused by somatic mosaic PIK3CA pathway mutations.
Limb Salvage
Limb salvage, or limb-sparing surgery, preserves an injured or tumor-bearing limb instead of amputating it. Used in sarcoma, severe trauma, and vascular disease; function and quality of life are comparable to amputation, with higher complications.
Limb-girdle muscular dystrophy
Limb-girdle muscular dystrophy (LGMD) is a group of inherited muscle disorders causing progressive weakness of the hip and shoulder muscles, with more than 29 genes known to cause it.
Limb-mammary syndrome
Limb-mammary syndrome (LMS, ORPHA 69085, OMIM 603543) is a rare autosomal dominant TP63-related ectodermal dysplasia with split-hand/foot anomalies, breast and nipple hypoplasia, and tooth and nail defects; distinct from TBX3-related ulnar-mammary syndrome.
Limbal stem cell deficiency
Limbal stem cell deficiency (LSCD), a rare corneal disorder (1-5/10,000) from loss or dysfunction of limbal stem cells, causing corneal conjunctivalization, neovascularization, and vision loss; treated with limbal transplants such as CLAU, SLET, and CLET.
Limbic system
Limbic system: forebrain structures common to all mammals (amygdala, hippocampus, hypothalamus, cingulate gyrus, septal nuclei, anterior thalamus) implicated in emotion, memory, and survival behaviors; term coined by MacLean in 1952 from Broca's 1878 limbic lobe and Papez's 1937 circuit.
Limertinib tablets
Limertinib tablets (Aoyixin, 奥壹新; ASK120067) are a third-generation EGFR tyrosine kinase inhibitor approved in China in 2025 for T790M-mutated and first-line EGFR-mutated NSCLC, with phase 3 PFS of 20.7 months versus gefitinib.
Limiting antigen-avidity enzyme immunoassay
The limiting antigen-avidity enzyme immunoassay (LAg-Avidity EIA) is a laboratory serological assay that measures HIV-1 antibody avidity to classify infections as recent or long-standing, estimating HIV incidence in population surveys.
LiMS trial
LiMS (LIght Monitor Study, NCT03050034) was an Italian pilot randomized trial of wearable wireless vital-sign monitoring (WIN@Hospital) versus nurse monitoring in critically ill Internal Medicine patients; no significant outcome differences, large nursing-time savings.
Lina Medina
Lina Medina is a Peruvian woman, born in 1933, who became the youngest confirmed mother in medical history, giving birth to son Gerardo at age five in 1939.
Linaclotide
Linaclotide (Linzess, Constella) is a 14-amino-acid guanylate cyclase-C agonist peptide for IBS-C, chronic idiopathic constipation, and pediatric functional constipation; US-approved 2012, pediatric IBS-C approval November 2025, main adverse effect diarrhea.
Linagliptin
Linagliptin (Trajenta, Tradjenta) is a DPP-4 inhibitor for type 2 diabetes, 5 mg once daily, eliminated mainly in faeces via bile, needing no dose adjustment in renal or hepatic impairment; CARMELINA and CAROLINA showed cardiovascular noninferiority.
Linamara Rizzo Battistella
Linamara Rizzo Battistella is a Brazilian physiatrist, Titular Professor at the University of São Paulo, and first São Paulo State Secretary for the Rights of Persons with Disabilities.