25,729 articles
Linaprazan glurate (X842)
Linaprazan glurate (X842, CX842) is an ester prodrug of the potassium-competitive acid blocker linaprazan, developed by Cinclus Pharma and approved in China in December 2024 for reflux esophagitis.
Linda A. Randolph
Linda A. Randolph is an American public health pediatrician in Washington, DC, known for longitudinal research on prenatal cocaine exposure and for co-founding the city's first birth center in 2000.
Linda C. Degutis
Linda C. Degutis is an American injury prevention researcher, Yale School of Public Health lecturer, and National Academy of Medicine member who directed the CDC's injury center from 2010 to 2014.
Linda Hazzard
Linda Burfield Hazzard (1867-1938), the 'Starvation Doctor' of Olalla, Washington, ran a fasting sanitarium called Starvation Heights; licensed as a Fasting Specialist without a medical degree, she was convicted of manslaughter in 1912 after at least 14 patients starved to death, and died during her own fast cure in 1938.
Lindsay Gibson
Lindsay C. Gibson, PsyD, American clinical psychologist in Virginia Beach and New York Times bestselling author of Adult Children of Emotionally Immature Parents (2015), which sold over a million copies; distinct from the romance novelist Lindsay Gibson.
Line probe assay
A line probe assay (LPA) is a nucleic acid test that amplifies DNA by multiplex PCR and detects it on a membrane strip, used for tuberculosis drug-resistance testing.
Linea nigra
Linea nigra, the pregnancy line, is a dark vertical line of hyperpigmentation on the midline of the abdomen, occurring in over 90% of pregnancies, caused by estrogen- and progesterone-driven melanin, fading after delivery.
Linear and whorled nevoid hypermelanosis
Linear and whorled nevoid hypermelanosis, or LWNH, is a rare, benign pigmentary disorder of newborns, delineated in 1988, in which streaky hyperpigmentation follows Blaschko's lines and most cases involve only the skin.
Linear atrophoderma of Moulin
Linear atrophoderma of Moulin (LAM), also called atrophoderma of Moulin, is a rare acquired dermatosis of hyperpigmented, atrophic band-like lesions along Blaschko's lines, first described in 1992, nonprogressive, with no proven treatment.
Linear focal elastosis
Linear focal elastosis (elastotic striae) is a rare benign acquired dermal elastosis with palpable yellow horizontal striae-like bands on the lower back, first described by Burket in 1989, male-predominant (5:1), requiring no treatment.
Linear gingival erythema
Linear gingival erythema (LGE), formerly HIV-gingivitis, is a fiery red 2-3 mm band along the free gingival margin in immunosuppressed people, mainly HIV, linked to Candida and unresponsive to plaque removal.
Linear IgA dermatosis
Linear IgA dermatosis (linear IgA bullous dermatosis, chronic bullous disease of childhood) is a rare autoimmune subepidermal blistering disease with linear IgA at the basement membrane zone, treated first with dapsone.
Linear lichen planus
Linear lichen planus, or Blaschkoid LP, is a rare lichen planus variant with pruritic violaceous papules along Blaschko lines, distinguished from lichen striatus histologically and treated first with topical corticosteroids.
Linear morphoea
Linear morphoea (linear scleroderma, ICD-11 EB61.1; en coup de sabre on the scalp) is a usually unilateral, childhood-onset band of skin fibrosis following Blaschko lines, with joint and neurologic complications in about 38% and systemic immunosuppressive treatment.
Linear nevus sebaceus syndrome
Linear nevus sebaceus syndrome, also called Schimmelpenning-Feuerstein-Mims, Schimmelpenning, or Solomon syndrome, is a rare disorder combining a congenital nevus sebaceus with eye, skeletal, and CNS abnormalities.
Linerixibat
Linerixibat (GSK2330672, Lynavoy) is an ileal bile acid transporter inhibitor for cholestatic pruritus in primary biliary cholangitis; approved in the US (2026) and UK, positive CHMP opinion, 40 mg twice daily, main side effect diarrhea.
Linezolid
Linezolid (Zyvox) is the first oxazolidinone antibiotic, FDA-approved April 18, 2000 for Gram-positive infections including MRSA and VRE; also used off-label for MDR-TB and XDR-TB with dose-related toxicity.
Lingual papillae
Lingual papillae (papillae linguales) are mucosal projections on the tongue's dorsal surface, of four types: filiform, fungiform, foliate, and circumvallate; only filiform lack taste buds, and fungiform are ectoderm-derived while circumvallate and foliate are endoderm-derived.
Linifanib
Linifanib (ABT-869), an oral VEGF/PDGF receptor tyrosine kinase inhibitor developed by Abbott for cancer; its phase III HCC trial against sorafenib failed the overall survival primary endpoint (9.1 vs 9.8 months).
Liniment
Liniment (embrocation): a liquid or semiliquid alcohol- or oil-based topical preparation rubbed into unbroken skin with friction, used mainly for muscle and joint pain; defined by the British Pharmacopoeia and regulated as an OTC external analgesic in the US.
Linked color imaging
Linked color imaging (LCI) is a Fujifilm endoscopy mode that amplifies reds and whites to increase color contrast, detecting early gastric cancers and colon adenomas better than white light.
Linperlisib
Linperlisib (林普利塞; development code YY-20394) is an oral, selective PI3K delta inhibitor developed by Shanghai Yingli Pharmaceutical and conditionally approved in China in 2022 for relapsed or refractory follicular lymphoma.
Linrodostat
Linrodostat (BMS-986205, ONO-7701) is an oral, irreversible apo-IDO1 inhibitor developed by Bristol Myers Squibb from Flexus Biosciences for cancer immunotherapy; phase 3 bladder cancer trials with nivolumab followed halted melanoma and lung programs.
Linsitinib
Linsitinib (OSI-906, ASP-7487, VGN-001) is an oral dual IGF-1R/insulin receptor kinase inhibitor (IC50 35/75 nM) that failed phase 3 in adrenocortical carcinoma and is now in phase 3 for thyroid eye disease.
Lintuzumab
Lintuzumab, also known as HuM195, is a humanized IgG1 monoclonal antibody targeting CD33 that was developed for acute myeloid leukemia and is now used in actinium-225 radioimmunotherapy trials.
Linzagolix
Linzagolix, marketed in Europe as Yselty, is an oral GnRH receptor antagonist, authorized in 2022 to treat uterine fibroids and endometriosis by lowering estrogen and progesterone.
Lionel Logue
Lionel Logue (1880-1953), Australian speech therapist and elocutionist at 146 Harley Street who treated King George VI's stammer from 1926, co-founded the British Society of Speech Therapists, and inspired The King's Speech.
Lionel M. Bernstein
Lionel M. Bernstein (1923–2019) was an American gastroenterologist at the University of Illinois and NIH, best known for the Bernstein test for reflux esophagitis and later a medical informatics leader.
Liothyronine
Liothyronine (L-T3, Cytomel) is the synthetic sodium salt of triiodothyronine, the active thyroid hormone, approved in 1956 for hypothyroidism, thyroid cancer TSH suppression, and suppression testing.
Lip augmentation
Lip augmentation is a cosmetic procedure that increases lip volume, shape, and definition, most commonly by injecting cross-linked hyaluronic acid filler lasting 6 to 12 months.