25,729 articles
mdx mouse
The mdx mouse is a mutant laboratory mouse lacking the muscle protein dystrophin, the standard animal model of Duchenne muscular dystrophy, arising spontaneously in 1981 and described in 1984.
Meacham syndrome
Meacham syndrome (Meacham-Winn-Culler syndrome), a very rare 46,XY disorder of sex development with ambiguous genitalia, diaphragmatic defects, complex congenital heart and lung malformations; 13 cases reported, WT1-related, poor prognosis.
Mean arterial pressure
Mean arterial pressure (MAP) is the average arterial pressure over the cardiac cycle, estimated as 1/3 systolic + 2/3 diastolic. Key targets: 65 mm Hg in septic shock; ambulatory thresholds <90/90-92/≥92 mmHg.
Mean corpuscular hemoglobin concentration
Mean corpuscular hemoglobin concentration (MCHC) is a red cell index, hemoglobin divided by packed cell volume, used in anemia classification and discriminant indices, with typical adult reference intervals near 31.9-35.5 g/dL.
Mean corpuscular volume
Mean corpuscular volume (MCV), or mean cell volume, is a CBC red cell index measuring average red blood cell size in femtoliters; normal adult range about 80-100 fL, classifying anemia as microcytic, normocytic, or macrocytic.
Mean platelet volume
Mean platelet volume (MPV) is the average platelet size in femtoliters from a routine blood count; healthy range 7.7–11.2 fL, inversely related to platelet count, sensitive to anticoagulant and analyzer, studied as a cardiovascular biomarker.
Measles
Measles (rubeola), a highly contagious morbillivirus infection with R0 12-18, airborne persistence up to 2 hours, immune amnesia, and 11 million estimated cases in 2024; prevented by two MMR doses (97% effective).
Measles and rubella vaccine, live, attenuated
Measles and rubella vaccine, live, attenuated (MR vaccine): freeze-dried bivalent live vaccine with Edmonston-Zagreb measles and Wistar RA 27/3 rubella strains, 1000 CCID50 each per 0.5 ml subcutaneous dose, WHO-prequalified since 2000.
Measles complicated by encephalitis
Measles complicated by encephalitis: brain inflammation from measles virus infection, about 1 per 1,000 cases, often causing permanent brain damage; includes ADEM, MIBE, and SSPE forms.
Measles vaccine
Measles vaccine, given as MMR or MMRV combination shots, is a live attenuated vaccine; two doses are 97% effective, with no evidence of autism risk and only small febrile seizure and ITP risks.
Measles vaccine, live, attenuated
Measles vaccine, live, attenuated (Edmonston-B, Edmonston-Enders strains; MMR/MMRV components): a live weakened measles virus vaccine licensed in 1963, 95% effective after one dose, 96% after two.
Measles without complication
Measles without complication is a clinical classification, ICD-10-CM code B05.9 and ICD-11 code 1F03.0, for measles that runs its course without complications such as pneumonia or encephalitis.
Measles, mumps and rubella vaccine, live, attenuated
Measles, mumps and rubella vaccine, live, attenuated: WHO-prequalified (since 8 Aug 2003, FVP-P-141) freeze-dried MMR vaccine by Serum Institute of India, Edmonston-Zagreb, Leningrad-Zagreb, and RA 27/3 strains, subcutaneous 0.5 ml dose.
Measurable residual disease detection
Measurable residual disease detection is a set of highly sensitive laboratory assays that count the few malignant cells remaining in bone marrow or blood after treatment.
MEASURE 1 trial
MEASURE 1 (NCT01358175) is Novartis's phase 3 trial of secukinumab, an anti-IL-17A antibody, in active ankylosing spondylitis: 371 patients, IV loading then subcutaneous 150 or 75 mg, ASAS20 61% vs 29% placebo at week 16, with 5-year extension data.
Measure Up 1 trial
Measure Up 1 (NCT03569293) is a phase 3 trial of once-daily upadacitinib 15 mg or 30 mg versus placebo in moderate-to-severe atopic dermatitis; EASI-75 at week 16 was 70-80% versus 16% on placebo.
Measured resection
Measured resection is a total knee replacement technique in which fixed bone cuts are sized to the patient's anatomy and implant, then ligaments are balanced by release.
Mebanazine
Mebanazine (Actomol) is a withdrawn hydrazine-class monoamine oxidase inhibitor antidepressant used in the 1960s for depression; formula C8H12N2, classified most-DILI-concern and excreted largely unchanged in rats.
Mebeverine
Mebeverine (Colofac, Duspatalin) is an antispasmodic direct smooth muscle relaxant for IBS cramps and pain, given as 135 mg tablets three times daily or 200 mg modified-release capsules twice daily; it has negligible oral bioavailability and meta-analyses show no significant benefit over placebo.
MEBP-OSA trial
MEBP-OSA (NCT06380491) is a Phase 4 open-label randomized trial at Mexico's Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán testing 3 mg daily melatonin for 30 days to treat insomnia and restore nocturnal blood pressure dipping in adults with OSA.
Mebutamate
Mebutamate (Capla, Dormate, W-583), CAS 64-55-1, is a discontinued meprobamate-derived biscarbamate sedative, anxiolytic, and antihypertensive; DEA Schedule IV (code 2800), ATC N05BC04, about one third secobarbital's sedative potency.
MEC-1
MEC-1 (MEC1) is a human B-cell leukemia cell line established in 1993 from a 61-year-old man with chronic lymphocytic leukemia, and one of the most widely used laboratory models for CLL.
Mecasermin rinfabate
Mecasermin rinfabate (iPlex, SomatoKine) is a recombinant 1:1 IGF-I/IGFBP-3 protein complex for severe primary IGF-1 deficiency; FDA approved December 2005, withdrawn 2007 after a patent settlement.
Mechanical debridement
Mechanical debridement is the nonselective removal of dead and viable tissue from wounds by physical force, using wet-to-dry gauze, irrigation, or pulsatile lavage; it is the most commonly used debridement technique in the USA.
Mechanical hemolytic anemia
Mechanical hemolytic anemia: red blood cells destroyed by shear stress and turbulence in thrombotic microangiopathy, malignant hypertension, prosthetic heart valves, and cardiac devices, producing schistocytes and intravascular hemolysis.
Mechanical lagophthalmos
Mechanical lagophthalmos is incomplete eyelid closure caused by physical obstruction such as proptosis, scarring, ectropion, or symblepharon, distinct from paralytic lagophthalmos; ICD-10 code H02.22, treated with lubricants, taping, tarsorrhaphy, and scar release.
Mechanical strabismus
Mechanical (restrictive) strabismus: eye misalignment from physical limitation of extraocular muscle movement, not nerve palsy. Causes include thyroid eye disease, orbital fractures, scarring, and congenital fibrosis; diagnosed with forced duction testing.
Mechanical thrombectomy for stroke
Mechanical thrombectomy for stroke is a catheter-based endovascular procedure that removes a clot from a large cerebral artery, the standard of care for large-vessel occlusion stroke.
Mechanical Thrombolysis
Mechanical thrombolysis, also called mechanical thrombectomy, removes blood clots physically via catheter devices rather than drugs. Key devices: Merci Retriever, Penumbra System, stent retrievers, aspiration catheters; standard of care for large vessel occlusion stroke.
Mechanical ventilation
Mechanical ventilation, also called artificial respiration or ventilator support, is life support that breathes for a patient via invasive tubes or masks. Defined by positive- and negative-pressure machines, the iron lung era, the 1952 Copenhagen polio epidemic, and lung-protective ARDS ventilation.