25,729 articles
Mepolizumab
Mepolizumab (Nucala) is GlaxoSmithKline's humanized anti-IL-5 IgG1 kappa monoclonal antibody, first FDA-approved November 2015 for severe eosinophilic asthma; 100 mg subcutaneously every 4 weeks, halving exacerbations, with later indications in CRSwNP, COPD, EGPA, and HES.
Meprednisone
Meprednisone (16-methylprednisone), also known by the brand name Betapar, is a synthetic glucocorticoid and methylated prednisone derivative, glucocorticoid receptor agonist, 4 mg oral tablet, discontinued.
Meprobamate
Meprobamate (Miltown, Equanil) is a carbamate anxiolytic synthesized in 1950 by Berger and Ludwig, approved 1955, Schedule IV in the US, suspended EU-wide in 2012, and the active metabolite of carisoprodol.
Meptazinol
Meptazinol, sold as Meptid, is an opioid analgesic of the hexahydroazepine class used for short-term relief of moderate-to-severe pain such as postoperative and renal colic pain.
Mequinol
Mequinol (4-hydroxyanisole, hydroquinone monomethyl ether) is a topical depigmenting agent, prescribed as 2% solution with 0.01% tretinoin (Solagé, US approval 1999) to treat solar lentigines; a tyrosinase substrate less irritating than hydroquinone.
MER6 trial
MER6 (Meropenem6, NCT05578586) is an Oslo University Hospital pilot trial comparing meropenem 1 g six times daily in 15-minute infusions against 2 g three times daily in 3-hour infusions, testing serum levels above 2 mg/L for over 50% of the day in 50 ICU patients.
Meralgia paraesthetica
Meralgia paraesthetica (Bernhardt-Roth syndrome), lateral femoral cutaneous nerve entrapment causing burning, tingling anterolateral thigh pain without motor loss; risk factors obesity, pregnancy, diabetes, tight clothing; treated conservatively first.
Merbromin
Merbromin, sold as Mercurochrome and Mercromina, is an organomercurial disodium salt (C20H8Br2HgNa2O6) red topical antiseptic for minor wounds; banned OTC in the US since 1998, still approved in Spain.
Mercaptopurine
Mercaptopurine (6-MP, Purinethol, Purixan) is a thiopurine antimetabolite discovered by Gertrude Elion and George Hitchings around 1950, FDA approved in 1953, used as maintenance therapy for acute lymphoblastic leukemia and as an immunosuppressant.
Merck & Co.
Merck & Co., also known as MSD outside the United States and Canada, is an American pharmaceutical company headquartered in Rahway, New Jersey, founded in 1891.
Merck Group
Merck Group (Merck KGaA, Darmstadt, Germany) is a family-controlled, Frankfurt-listed science and technology company founded in 1668, operating Life Science, Healthcare, and Electronics sectors; in North America it uses the EMD and MilliporeSigma brands, distinct from Merck & Co.
Mercury poisoning
Mercury poisoning, also called mercurialism or Minamata disease in its outbreak form, is toxicity from elemental, inorganic, or organic mercury, chiefly methylmercury in fish and mercury vapor at work, damaging the nervous system and kidneys.
MERIDIAN trial
MERIDIAN trial (NCT05265988), a completed phase II single-arm Italian study of cabozantinib bone response in heavily pretreated mCRPC; distinct from MERIDIAN HNSCC, MERIDIAN ALS, and MERLIN trials.
Merkel cell
Merkel cell (Tastzelle), an epidermal mechanosensory cell in the basal skin layer, forming the Merkel cell-neurite complex with Aβ SA1 fibers for light touch; PIEZO2-dependent, ATOH1-specified, epidermal origin; linked to Merkel cell carcinoma.
Merkel-cell carcinoma
Merkel-cell carcinoma (MCC), also called trabecular cancer, is a rare aggressive neuroendocrine skin cancer linked to Merkel cell polyomavirus in about 80% of cases; incidence is rising, and anti-PD-1/PD-L1 immunotherapy is first-line for advanced disease.
Merlin K. DuVal
Merlin K. DuVal, known as Monte DuVal, was an American surgeon who founded the University of Arizona College of Medicine and served as U.S. Assistant Secretary for Health from 1971 to 1973.
Meropenem
Meropenem (MERREM IV), a broad-spectrum intravenous carbapenem antibiotic approved in the US in 1996, treats complicated skin, intra-abdominal, and meningeal infections; stable to dehydropeptidase I and most beta-lactamases, with valproic acid interaction.
Mersalyl
Mersalyl (Salyrgan), sodium salt of mersalyl acid, an organomercury diuretic introduced in 1924 for edema; acts by binding protein sulfhydryl groups, toxic, discontinued by FDA, replaced by thiazides and loop diuretics.
MESA-Eye study
MESA-Eye (MESA Eye ancillary study) is the eye component of the Multi-Ethnic Study of Atherosclerosis, collecting retinal fundus photographs and refraction data from MESA participants to link retinal microvascular signs with cardiovascular risk, stroke, and eye disease.
Mesalazine
Mesalazine (mesalamine, 5-ASA) is a topical anti-inflammatory drug, the active moiety of sulfasalazine, used first-line for mild-to-moderate ulcerative colitis and colonic Crohn's disease; delivered via pH-dependent, time-dependent, azo-bonded, and rectal formulations.
Mesenchymal stem cell transplantation
Mesenchymal stem cell transplantation is a cell therapy that infuses culture-expanded stromal cells from bone marrow, fat, or umbilical cord to treat inflammatory and degenerative conditions.
Mesenchymal stromal cell therapy
Mesenchymal stromal cell (MSC) therapy is a cell-based treatment that uses stromal cells from bone marrow, adipose tissue, or umbilical cord to dampen inflammation and support tissue repair.
Mesenteric peritonitis
Mesenteric peritonitis (ICD-11 DC50.11) is a specified secondary peritonitis defined as peritonitis due to mesenterial fat necrosis or saponification; ICD-10-CM equivalent K65.8, ICD-10-AM K65.22.
Mesentery
Mesentery: continuous double fold of peritoneum attaching the intestines to the posterior abdominal wall, carrying vessels, lymphatics, and nerves; redesignated a single organ in 2016, spanning duodenojejunal flexure to anorectal junction.
Mesh hernioplasty
Mesh hernioplasty is the repair of an abdominal wall hernia by reinforcing the defect with synthetic or biologic mesh, so the closure is tension-free rather than sewn tissue alone.
Mesh rectopexy
Mesh rectopexy is a surgical operation that uses a strip of synthetic or biological mesh to fix the rectum to the sacral promontory, treating rectal prolapse.
Mesial temporal lobe epilepsy with hippocampal sclerosis
Epilepsy with mesial temporal sclerosis (ICD-11 8A60.7), also called epilepsy with hippocampal or Ammon's horn sclerosis: focal epilepsy from hippocampal scarring, often after childhood febrile seizures, frequently drug-resistant but highly surgically treatable.
Mesna
Mesna is a cytoprotective drug, sold as Mesnex and Uromitexan, that binds toxic ifosfamide metabolites in urine to prevent hemorrhagic cystitis during chemotherapy; it was approved in the United States in 1988.
Mesoaxial synostotic syndactyly with phalangeal reduction
Mesoaxial synostotic syndactyly with phalangeal reduction (MSSD, syndactyly type 9, Malik-Percin type, OMIM 609432) is an extremely rare autosomal recessive limb malformation with fused 3rd-4th fingers, metacarpal synostosis, and BHLHA9 mutations.
Mesocardia
Mesocardia, or midline heart, is a rare congenital malposition in which the heart sits centrally in the thorax with a midline apex; usually normal atrial situs, possibly inverted ventricles, about 0.2% of congenital anomalies.