25,729 articles
Methenamine
Methenamine (hexamethylenetetramine, hexamine, urotropine) is a urinary antiseptic, discovered 1859, used as hippurate salt since 1895; hydrolyzed to formaldehyde in acid urine to prevent recurrent UTIs without bacterial resistance.
Methimazole embryofetopathy
Methimazole embryofetopathy is a pattern of birth defects from first-trimester maternal exposure to methimazole or carbimazole, including choanal and esophageal atresia, omphalocele, and aplasia cutis.
Methiodal
Methiodal (iodomethanesulfonic acid, Abrodil) is an iodinated organosulfonic acid whose sodium salt served as a water-soluble, high-osmolar X-ray contrast medium for urography, introduced around 1930-1931 and later withdrawn.
Methionine adenosyltransferase I/III deficiency
Methionine adenosyltransferase I/III deficiency, also called Mudd's disease, is a rare inherited metabolic disorder in which MAT1A gene mutations raise blood methionine; most people are unaffected, but some develop neurological problems including brain demyelination.
Methixene
Methixene (metixene, Tremaril, Trest) is a discontinued tertiary antimuscarinic anticholinergic, ATC N04AA03, C20H23NS, used for parkinsonism and GI spasm via muscarinic antagonism in the corpus striatum.
Methocarbamol
Methocarbamol, sold as Robaxin, is a prescription skeletal muscle relaxant and CNS depressant, first approved in the United States in 1957, used for acute painful musculoskeletal conditions.
Methodius Gamuo Tuuli
Methodius Gamuo Tuuli is a maternal-fetal medicine physician and clinical trials researcher who chairs Obstetrics and Gynecology at Brown University and was elected to the National Academy of Medicine in 2023.
METHODO trial
METHODO (NCT02887053) is a monocentric interventional MRI methods study at Central Hospital, Nancy, France, led by Valérie Laurent and Jacques Felblinger, evaluating image quality and quantitative MRI sub-studies in cardiac, breast, brain, and speech imaging.
Methohexital
Methohexital, also known as methohexitone or Brevital, is an ultrashort-acting intravenous barbiturate used to induce anesthesia, most prominently as the standard anesthetic for electroconvulsive therapy.
Methopholine
Methopholine (metofoline, Versidyne, Ro 4-1778/1) is a synthetic tetrahydroisoquinoline opioid analgesic introduced in the USA in the early 1960s for mild to moderate pain and withdrawn by FDA in March 1965 over corneal opacities in dog toxicity studies.
Methotrexate
Methotrexate (MTX, amethopterin) is an antifolate antimetabolite inhibiting dihydrofolate reductase, used for ALL and other cancers, rheumatoid arthritis, psoriasis, and ectopic pregnancy; approved in the US for cancer in 1955.
Methotrexate and prednisone combination therapy
Methotrexate and prednisone combination therapy pairs methotrexate with prednisone so prednisone controls inflammatory symptoms while methotrexate builds its effect, used mainly in early rheumatoid arthritis and giant-cell arteritis.
Methotrexate and vinblastine regimen
The methotrexate and vinblastine regimen is a two-drug intravenous chemotherapy combination used mainly for advanced urothelial carcinoma and desmoid-type fibromatosis, and forms the backbone of MVAC.
Methotrexate regimen
A methotrexate regimen is a dosing protocol for the antifolate drug methotrexate, given alone or with other agents to treat cancers, rheumatoid arthritis, and psoriasis, with doses spanning several thousand-fold.
Methotrexate toxicity
Methotrexate toxicity (ORPHA:565782) is a rare intoxication from the antifolate methotrexate: renal tubular crystal injury causing acute kidney injury, plus myelosuppression, mucositis, and hepatotoxicity, managed with leucovorin and glucarpidase.
Methotrexate-associated lymphoproliferative disorders
Methotrexate-associated lymphoproliferative disorders (MTX-LPD, OIIA-LPD) are EBV-related lymphoid proliferations or lymphomas arising in autoimmune disease patients on methotrexate, often regressing after drug withdrawal.
Methoxyflurane
Methoxyflurane (Penthrane, Penthrox, green whistle) is a volatile fluorinated hydrocarbon anesthetic introduced in 1960, withdrawn for anesthesia by the late 1970s over fluoride-mediated nephrotoxicity, and now used as a self-administered 3 mL inhaled analgesic in Australasia and Europe.
Methsuximide
Methsuximide (Celontin), an anticonvulsant succinimide chemically known as N,2-dimethyl-2-phenylsuccinimide, treats absence seizures refractory to other drugs; FDA-approved 1957 by Parke-Davis, active via N-desmethylmethsuximide metabolite.
Methyclothiazide
Methyclothiazide (Enduron, Aquatensen) is a thiazide diuretic and sodium chloride symporter inhibitor for hypertension and edema, about 100 times more potent per mg than chlorothiazide, excreted unchanged in urine; US products are discontinued.
Methyldopa
Methyldopa (alpha-methyldopa, Aldomet) is a centrally acting antihypertensive prodrug converted to alpha-methylnorepinephrine, an alpha-2 agonist. Developed in the 1950s, now used mainly for hypertension in pregnancy; causes sedation and depression.
Methylene blue
Methylene blue, a phenothiazine dye synthesized by Caro in 1876, is the standard antidote for methemoglobinemia (1 mg/kg IV), a stain, and an investigational NO-cGMP inhibitor in vasodilatory shock with unproven mortality benefit.
Methylenedioxypyrovalerone
Methylenedioxypyrovalerone (MDPV) is a pyrrolidinophenone synthetic cathinone stimulant from bath salts; a potent DAT/NET uptake blocker, more reinforcing than cocaine in animals, Schedule II internationally.
Methylhomatropine
Methylhomatropine, sold as homatropine methylbromide (CAS 80-49-9), is a quaternary ammonium muscarinic antagonist derived from homatropine, used in antacid antispasmodic combinations and formerly with hydrocodone in Hycodan.
Methylisothiazolinone
Methylisothiazolinone (MI, MIT, 2-methyl-4-isothiazolin-3-one), a preservative used with MCI as Kathon and alone in cosmetics since 2005, caused an epidemic of allergic contact dermatitis and was 2013 Allergen of the Year.
Methylmalonic acidemia due to methylmalonyl-CoA epimerase deficiency
MCEE deficiency (OMIM 251120, ORPHA 308425), an ultra-rare autosomal recessive inborn error of metabolism causing mild-to-moderate persistent methylmalonic acid elevation, B12-nonresponsive, with a clinical spectrum from asymptomatic to acute decompensation.
Methylmalonic acidemia with homocystinuria
Methylmalonic acidemia with homocystinuria, also called cobalamin C (cblC) disease, is an inherited vitamin B12 metabolism defect causing methylmalonic acid and homocysteine buildup; genes include MMACHC, MMADHC, LMBRD1, ABCD4, HCFC1.
Methylnaltrexone
Methylnaltrexone (Relistor) is a quaternary naltrexone derivative, the first peripherally acting mu-opioid receptor antagonist, given subcutaneously or orally for opioid-induced constipation without reducing analgesia.
Methylphenidate
Methylphenidate (Ritalin, Concerta) is a racemic CNS stimulant and dopamine/noradrenaline reuptake inhibitor approved for ADHD ages 6+ and narcolepsy; SMD −0.78 efficacy, ~24M US prescriptions, Schedule II, WHO essential medicine 2023.
Methylprednisolone
Methylprednisolone (Medrol, Solu-Medrol, Depo-Medrol) is a synthetic prednisolone-derivative glucocorticoid used orally and by injection for inflammatory and immunosuppressive therapy, with greater anti-inflammatory potency than prednisolone.
Methylpromazine
Methylpromazine, also called alimemazine or trimeprazine (Vallergan), is a phenothiazine-derivative sedating antihistamine and neuroleptic synthesized in France in 1958, with H1-antagonist and dopamine-blocking effects, used for sedation, pruritus, and nausea.