edgepedia

Human health and medicine

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Muscle fatigue

Muscle fatigue: exercise-induced reduction in a muscle's force or power capacity, split into central (reduced voluntary activation) and peripheral (impaired EC coupling, calcium, metabolites) mechanisms.

Muscle hypertrophy

Muscle hypertrophy, also called skeletal muscle growth, is the enlargement of muscle fibers via net protein accretion driven by resistance training; volume is the key dose-response variable, while load, frequency, and training to failure matter less than commonly assumed.

Muscle Relaxation

Muscle relaxation is the twitch phase in which muscle returns to rest, driven by SERCA pumping calcium back into the sarcoplasmic reticulum; fatigue, low temperature, aging, and spasticity slow it.

Muscle spindle

Muscle spindle (Muskelspindeln): encapsulated stretch receptor in skeletal muscle, built of intrafusal bag and chain fibers with Ia and II afferents and gamma motor innervation; signals muscle length and stretch velocity for proprioception and the stretch reflex.

Muscle strain or sprain

Muscle strain or sprain (ICD-11 FB32.5): a strain injures a muscle or tendon, a sprain a ligament; also called pulled muscle. Treated with PRICE; graded I-III; common in hamstrings, adductors, quadriceps, calf.

Muscle Strength

Muscle strength: the maximal force generated by muscle contraction, measured isometrically, isotonically, or isokinetically via manual muscle testing (MRC 0-5 scale) or dynamometers, from 1763 devices to modern hand-held and isokinetic dynamometry.

Muscle Strength Dynamometer

Muscle strength dynamometer: device measuring isometric force of muscles or muscle groups, from 1763 spring devices to hand-held (HHD) and isokinetic dynamometry, the gold standard; HHD offers portable, valid, lower-cost clinical strength testing.

Muscle tension dysphonia

Muscle tension dysphonia (MTD), primary or secondary, is a functional voice disorder from excessive paralaryngeal muscle tension causing hoarseness and vocal fatigue; treated mainly with voice therapy.

Muscle tone

Muscle tone is the resting tension in skeletal muscle, combining active neural (stretch reflex, gamma drive) and passive viscoelastic components; clinically assessed by resistance to passive movement, with hypertonia (spasticity, rigidity) or hypotonia as abnormalities.

MUSCLE trial

MUSCLE (Nordic Walking in MUltiple SCLErosis), NCT05385731, is a randomized multicentre trial by Peyré-Tartaruga comparing Nordic walking, free walking, and health education in 60 sedentary adults with multiple sclerosis, with gait-mechanics and quality-of-life outcomes.

Muscle weakness

Muscle weakness, or true loss of muscle strength (distinct from asthenia, fatigue), arises from lesions of upper or lower motor neurons, the neuromuscular junction, or muscle; graded on the MRC 0-5 scale, it affects about 5% of U.S. adults 60 and older.

Muscle-eye-brain disease

Muscle-eye-brain disease (MEB, Santavuori congenital muscular dystrophy) is a rare autosomal recessive dystroglycanopathy caused by POMGnT1 mutations, combining congenital muscular dystrophy, severe intellectual disability, and brain and eye malformations.

Muscle-up

Muscle-up: advanced gymnastics and calisthenics exercise combining a pull-up and dip on rings or a bar; strict and kipping forms; CrossFit standards and Walker et al. 2023 EMG comparison of bar versus ring versions.

Muscles of respiration

Muscles of respiration: the diaphragm, intercostal and accessory muscles, and abdominal muscles that drive breathing; diaphragm is the main inspiratory muscle, with scalenes and parasternal intercostals assisting.

Muscles of the hand

Muscles of the hand: extrinsic forearm-bellied muscles and 19 intrinsic muscles in four groups (thenar, hypothenar, interossei, lumbricals), ulnar/median innervation, and claw versus intrinsic-plus deformities.

Muscles of the hip

Muscles of the hip: 21 muscles crossing the hip joint, grouped as flexors, extensors, abductors, adductors, and the six deep external rotators (piriformis, obturator internus and externus, gemelli, quadratus femoris), with attachments, architecture, and surgical relevance.

Muscular dystrophy

Muscular dystrophy, including Duchenne (DMD) and Becker types, is a group of inherited, progressive skeletal muscle disorders caused by altered genes such as DMD on Xp21; diagnosis is now genetic-testing-first, with biopsy reserved for inconclusive cases.

Muscular Dystrophy Association

Muscular Dystrophy Association (MDA), founded 1950 by Paul Cohen in Rye, NY, is a Chicago-based 501(c)(3) voluntary health organization for muscular dystrophy, ALS, and 300+ neuromuscular diseases; distinct from the UK MND Association and the New Zealand MDA.

Muscular dystrophy diagnosis and screening

Muscular dystrophy diagnosis and screening is the set of tests used to diagnose muscular dystrophies, from creatine kinase blood testing and genetic analysis to muscle biopsy, MRI, and newborn screening.

Muscular hypertonia

Muscular hypertonia, also called muscle hypertonia or increased muscle tone, is abnormally stiff, resistant muscles from upper motor neuron lesions, classified as spasticity, rigidity, dystonia, or paratonia; ICD-11 code MB47.8.

Muscular pseudohypertrophy-hypothyroidism syndrome

Muscular pseudohypertrophy-hypothyroidism syndrome, or Kocher-Debré-Sémélaigne syndrome (ORPHA:2349, ICD-10 E03.1), is a rare childhood disorder causing muscle pseudohypertrophy from longstanding hypothyroidism, reversible with levothyroxine; Hoffmann syndrome is its adult counterpart.

Muscular system

Muscular system: the skeletal muscles and their connective tissues, over 600 muscles making up nearly half of body mass; also covers cardiac and smooth muscle, contraction, fatigue, and sarcopenia.

Musculocontractural Ehlers-Danlos syndrome

Musculocontractural Ehlers-Danlos syndrome (mcEDS), also called adducted thumb-clubfoot syndrome or Dundar syndrome, is an ultra-rare autosomal recessive connective tissue disorder caused by CHST14 or DSE variants, with congenital contractures, craniofacial features, and fragile skin.

Musculoskeletal and hematologic manifestations of systemic lupus erythematosus

The musculoskeletal and hematologic manifestations of systemic lupus erythematosus are joint, muscle, and blood abnormalities affecting 80–90% of SLE patients, including nonerosive arthritis, Jaccoud's arthropathy, anemia, and thrombocytopenia.

Musculoskeletal examination

The musculoskeletal examination is a clinical method in which a physician inspects, palpates, and moves the joints, muscles, and bones to detect abnormalities and diagnose musculoskeletal disorders.

MUSEUM trial

MUSEUM (NCT03159078) is a phase 3, double-blind randomized trial at the Puerto Rico Trauma Hospital ICU comparing polymyxin B monotherapy versus polymyxin B-carbapenem (imipenem) combination therapy in critically ill trauma patients with multidrug-resistant gram-negative infections; planned enrollment 40, no results posted.

Mushroom edible

Edible mushrooms: fungal fruiting bodies safe for food, wild or cultivated. About two dozen species commercially accepted; China leads production (43.34 million tons, 2023); rich in protein, B vitamins; wild types need expert identification.

MuSIFe study

MuSIFe (Multidisciplinary Surveillance and Investigation of Febrile Illness in Guinea), NCT06122259, is a prospective observational cohort study of 2,500 febrile patients in four sentinel districts, run by Guinea's CNFERSR with the Institute of Tropical Medicine, Antwerp.

Mustakaranjadi kvatha curna

Mustakaranjadi kvatha curna (Mustākaraṅjādi kvātha cūrṇa) is an eight-herb Ayurvedic coarse-powder decoction, AFI entry 4:26 from the Sahasrayoga, dosed at 48 g and indicated for atisara (diarrhea) and sula (colicky pain).

MUSTAKARISTA

Mustakarista (Mustakāriṣṭa, Mustakarishta) is a fermented Ayurvedic asava-arista liquid formulation based on Cyperus rotundus, jaggery and Woodfordia fruticosa, used for dyspepsia, anorexia, diarrhoea, and dysentery; AFI dose 12-24 ml.