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Paul Grant Rogers
Paul Grant Rogers (1921–2008) was an American lawyer and Democratic U.S. Representative from Florida who shaped most major American health legislation over 24 years in Congress, earning the nickname "Mr. Health".
Paul Kalanithi
Paul Kalanithi (1977-2015), American neurosurgeon at Stanford, author of the posthumous memoir When Breath Becomes Air, written after his stage IV EGFR-positive lung cancer diagnosis; Pulitzer finalist and No. 1 NYT bestseller.
Paul Karason
Paul Karason, the American "Blue Man," developed permanent argyria from drinking homemade colloidal silver daily and died in 2013 at 62; his case publicized FDA warnings about colloidal silver.
Paul Nassif
Paul S. Nassif (born 1962) is a Lebanese-American, double board-certified facial plastic surgeon in Beverly Hills, a revision rhinoplasty specialist, co-star of E!'s Botched with Terry Dubrow, and founder of NassifMD Skincare.
Paul P. Lee
Paul P. Lee, full name Paul Pue-Jung Lee, is an American ophthalmologist and health-services researcher at the University of Michigan, elected to the National Academy of Medicine.
Paul S. Frame
Paul S. Frame is an American family medicine physician and clinical prevention researcher at the University of Rochester, elected to the Institute of Medicine in 1988.
Paul Saladino
Paul Saladino, "Carnivore MD," is an American psychiatrist-turned-influencer, author of The Carnivore Code, promoter of the animal-based diet (meat, organs, fruit, honey, raw dairy), and co-founder of Heart & Soil and Lineage Provisions.
PAUSE 2 RCT trial
PAUSE-2 pilot randomized trial (NCT04192552): open-label RCT by Douketis et al. comparing PAUSE-based versus ASRA-based perioperative DOAC management in 159 atrial fibrillation patients needing high-bleed-risk surgery or neuraxial anesthesia; similar residual DOAC levels in both arms.
Pazufloxacin
Pazufloxacin (T-3761), a synthetic fluoroquinolone antibiotic from Toyama Chemical, oral and injectable mesylate (T-3762) forms, launched in Japan in 2002, used for respiratory, urinary, and enteric bacterial infections.
PC-3
PC-3 (CVCL_0035, ATCC CRL-1435) is a human prostate cancer cell line established in 1979 from a bone metastasis in a 62-year-old man; androgen-insensitive, AR- and PSA-negative, highly metastatic, with neuroendocrine features.
PCA3
PCA3 (prostate cancer antigen 3, DD3) is a long non-coding RNA overexpressed in prostate cancer and measured in post-DRE first-catch urine; the FDA-approved PROGENSA assay (P100033, 2012, withdrawn 2023) computes a PCA3/PSA RNA ratio score, cutoff 25, for repeat-biopsy decisions.
PCA3 test
The PCA3 test is a urine-based molecular diagnostic measuring prostate cancer antigen 3 RNA after a digital rectal exam; FDA-approved in 2012, it was withdrawn in 2023.
PCDH19 clustering epilepsy
PCDH19 clustering epilepsy (PCDH19-CE, formerly EFMR or girls clustering epilepsy) is a rare X-linked epilepsy caused by PCDH19 variants, affecting heterozygous females via cellular interference, with fever-triggered seizure clusters beginning in infancy.
PCLS study
Pennington Center Longitudinal Study (PCLS, NCT00959270): prospective cohort at Pennington Biomedical Research Center, Baton Rouge, studying obesity, activity, and diet against chronic disease and mortality; ~30,000 enrollees; found visceral fat predicts death in whites.
PCM-EVW-ES study
PCM-EVW-ES (Perfil Clínico y Molecular de la Enfermedad de von Willebrand en España) is a Spanish multicenter VWD registry begun in 2010 that used NGS of VWF in 556 individuals, diagnosing 480 patients and identifying 704 variants, 155 novel.
PD-1 and PD-L1 inhibitors
PD-1 and PD-L1 inhibitors are immune checkpoint blocker antibodies (nivolumab, pembrolizumab; atezolizumab, durvalumab, avelumab) that restore T-cell killing of PD-L1-expressing tumors; first FDA-approved 2014, 2018 Nobel recognized.
PDE4D7
PDE4D7 is a splice variant of the PDE4D gene that degrades cAMP and acts as a tumor suppressor in prostate cancer, where its loss predicts poor survival.
PDE5 inhibitor
PDE5 inhibitors (sildenafil/Viagra, tadalafil/Cialis, vardenafil, avanafil) block phosphodiesterase type 5, prolonging NO-cGMP signalling. Developed for angina, approved for erectile dysfunction from 1998 and pulmonary arterial hypertension; nitrates are contraindicated.
PDNONG trial
PDNONG (NCT07321470) is a randomized trial at National Taiwan University Hospital testing complete nasogastric tube omission (CONGT, thick needle suction) versus postoperative-only omission (PONGT) after pancreaticoduodenectomy in 240 patients, primary endpoint Clavien-Dindo grade II or higher complications within 90 days.
Peak expiratory flow
Peak expiratory flow (PEF, PEFR) is the maximum airflow speed during a forced expiration, measured in L/min with a peak flow meter; used to diagnose and monitor asthma via personal best scores and action plans.
Peanut allergy
Peanut allergy: IgE-mediated food allergy to peanut proteins (Ara h 1–11, chiefly Ara h 2), affecting 0.2–4.5% of populations, usually lifelong, a leading cause of anaphylaxis; managed by avoidance, epinephrine, OIT (Palforzia), and omalizumab (2024).
PEARL study
PEARL study (Prospective Evaluation of Atrial fibrillation-Related Stroke patients in rehabilitation programme), a TARGET-project observational cohort at Hospital del Mar, Barcelona, comparing 6-month Barthel Index outcomes of AFRS vs non-AFRS stroke patients in high- vs moderate-intensity rehabilitation; distinct from the migraine and exercise-assistant PEARL studies.
Pearly penile papules
Pearly penile papules (PPP), also called hirsutoid papillomas or papillomatosis corona penis, are benign 1-2 mm pink, white, or yellow bumps in rows around the corona of the glans penis; not an STI, common in uncircumcised men, needing no treatment.
PECS block
The PECS (pectoral nerve) block is an ultrasound-guided fascial plane block that numbs the anterior chest wall, used mainly for breast surgery and pacemaker insertion.
Pectoral nerve block II
The pectoral nerve block II (PECS II) is an ultrasound-guided nerve block of the chest wall, introduced in 2012 and used mainly as an opioid-sparing adjunct for breast surgery.
Pectus carinatum
Pectus carinatum (pigeon chest) is a congenital chest wall deformity with outward sternal protrusion, second most common after pectus excavatum, male-predominant 3-4:1, treated first with orthotic bracing and secondarily by Ravitch or Abramson surgery.
Pectus excavatum
Pectus excavatum (funnel chest, sunken chest) is the most common congenital chest wall deformity, a concave sternum from abnormal costal cartilage growth, treated by Ravitch or Nuss surgery or vacuum bell therapy.
PED_HUIL0124 trial
PED_HUIL0124 (NCT06222229) is a Spanish multicenter randomized trial at Hospital Universitario Infanta Leonor comparing functional bandaging versus no immobilization in children aged 5-16 with mild ankle sprain, using OXAFQ-C and pain outcomes.
Pediarix
Pediarix (DTaP-HepB-IPV), GlaxoSmithKline's pentavalent infant vaccine licensed December 13, 2002 (BLA 103907), given as a 3-dose series at 2, 4, 6 months to HBsAg-negative mothers' infants aged 6 weeks to 6 years; not for birth dose or boosters.
Pediatric acute myeloid leukemia
Pediatric acute myeloid leukemia (AML) is a rare cancer of myeloid blood-forming cells in children and young adults, genetically distinct from adult AML and treated with intensive multi-cycle chemotherapy.