Human health and medicine

Sacituzumab drozuntecan

DB-1305/BNT325 (sacituzumab drozuntecan) is DualityBio's third-generation TROP2-targeting ADC using topoisomerase-I inhibitor P1021 on the DITAC platform; partnered with BioNTech ex-Greater China, in Phase I/IIa trials (NCT05438329) with FDA Fast Track designation.

Sacituzumab govitecan

Sacituzumab govitecan (Trodelvy, sacituzumab govitecan-hziy) is a Trop-2-directed antibody-drug conjugate linking a humanized anti-Trop-2 antibody to SN-38, a topoisomerase I inhibitor; FDA-approved since 2020 for metastatic triple-negative and HR+/HER2- breast cancer.

Oct 20, 2026

Sacituzumab tirumotecan

Sacituzumab tirumotecan, also known as sac-TMT or SKB264, is an antibody-drug conjugate targeting TROP2 that was developed by Sichuan Kelun-Biotech and approved in China in 2025.

Sackler family

Sackler family, American dynasty of Arthur, Mortimer, and Raymond Sackler, owners of Purdue Pharma; their 1996 OxyContin marketing fueled the US opioid epidemic, leading to a $7.4 billion settlement and widespread denaming.

Sacral and coccygeal spinal nerves

The sacral and coccygeal spinal nerves are five pairs of sacral nerves (S1–S5) and one coccygeal nerve, the lowest spinal nerves, supplying the pelvis and lower limb.

Sacral dimple

A sacral dimple, also called a pilonidal dimple, is a small indentation in the skin over the sacrum present at birth in about 2 to 5 percent of newborns.

Sacral nerve stimulation

Sacral nerve stimulation, also called sacral neuromodulation, is a treatment in which an implanted device stimulates the S3 nerve to relieve urinary urgency, retention, and fecal incontinence.

Sacral plexus

Sacral plexus (plexus sacralis): pelvic nerve network formed by the lumbosacral trunk (L4, L5) and S1–S4, anterior to piriformis; gives the sciatic, gluteal, posterior femoral cutaneous, perforating cutaneous, and pudendal nerves and the S2–S3 parasympathetic outflow.

Sacrectomy

Sacrectomy is the surgical removal of all or part of the sacrum, performed in orthopedic oncology mainly for sacral chordoma and recurrent rectal cancer, ranging from partial to total resection.

Sacrococcygeal pilonidal abscess

Sacrococcygeal pilonidal abscess (ICD-11 EG63.2), the acute infected form of pilonidal disease at the natal cleft; treated by lateral incision and drainage, then definitive surgery; recurrence up to 42% after drainage alone.

Oct 20, 2026

Sacrococcygeal pilonidal sinus

A sacrococcygeal pilonidal sinus is a chronic, hair-containing tract in the skin at the top of the natal cleft, above the sacrum, mainly affecting young adults.

Sacrocolpopexy

Sacrocolpopexy, performed open or laparoscopically, repairs apical pelvic organ prolapse by anchoring the vaginal apex to the sacrum with mesh, and is considered the gold standard repair.

Sacrohysteropexy

Sacrohysteropexy is a uterus-sparing surgical procedure for uterine prolapse in which a strip of synthetic mesh anchors the uterus to the sacrum, done open, laparoscopically, or robotically.

Sacroiliac joint

Sacroiliac joint (SIJ): bilateral sacrum-ilium articulation, the body's largest axial joint, transferring spinal load to the legs; moves under 3 degrees and 2 mm, and contributes to 15-30% of low back pain.

Sacroiliac joint dysfunction

Sacroiliac joint dysfunction, also called SIJ pain or sacroiliac joint syndrome, is pain from the sacroiliac joint causing 10-33% of chronic low back pain, diagnosed by clustered provocation tests and anesthetic blocks, treated with physical therapy, injections, radiofrequency ablation, or fusion.

Sacroiliitis

Sacroiliitis is inflammation of one or both sacroiliac joints, causing buttock and lower back pain; a hallmark of axial spondyloarthritis, diagnosed by X-ray or MRI, treated with NSAIDs, biologics, and injections.

Sacrosidase

Sacrosidase (Sucraid) is a baker's yeast-derived sucrase enzyme oral solution, 8,500 IU/mL, FDA-approved April 9, 1998 as the only enzyme replacement therapy for sucrase deficiency in congenital sucrase-isomaltase deficiency, patients 5 months and older; it does not digest starch.

Sacrospinous ligament fixation

Sacrospinous ligament fixation is a vaginal operation for pelvic organ prolapse that anchors the vaginal apex or uterus to the sacrospinous ligament, restoring apical support.

Sacrum

Sacrum (os sacrum): triangular bone of five fused vertebrae at the base of the spine, transferring trunk weight to the pelvis via the auricular surfaces; 58-60 ossification centers, four foramina pairs, common sacralization and coccygeal fusion variations.

Sacubitril

Sacubitril is a prodrug converted to sacubitrilat (LBQ657), a neprilysin inhibitor; combined with valsartan as Entresto (LCZ696), an ARNI approved by FDA in 2015 for HFrEF after PARADIGM-HF showed 20% lower cardiovascular death versus enalapril.

Sacubitril allisartan calcium tablets

Sacubitril allisartan calcium tablets (沙库巴曲阿利沙坦钙片, 信超妥) are Salubris's ARNI co-crystal of sacubitril and allisartan for primary hypertension; first Chinese-developed ARNI, second globally, approved May 2025, dosed 240 mg once daily.

Sacubitril/valsartan

Sacubitril/valsartan (Entresto, LCZ696) is an angiotensin receptor-neprilysin inhibitor for heart failure, approved in the US in 2015; PARADIGM-HF showed 20% lower cardiovascular death than enalapril in HFrEF.

Sadabindu Taila

Sadabindu Taila is a classical Ayurvedic medicated sesame oil instilled into the nostrils as Nasya, traditionally used for head diseases, loose teeth, weak eyesight, and hair loss.

Sadanga kvatha curna

Sadanga kvatha curna (Ṣaḍaṅga kvātha cūrṇa) is a six-ingredient Ayurvedic decoction powder, AFI entry 4:32 from the Astangahrdaya, used for nausea, thirst, and fever with bitterness; AFI dose 48 g.

Sadbindu Taila

Sadbindu (Shadbindu, Ṣaḍbindu) Taila, a classical Ayurvedic nasya oil from Bhaishajya Ratnavali 49–51, made of processed sesame oil, Eclipta alba juice, goat milk, and nine herbs; used for head and nasal disorders, standardized by HPTLC kaempferol assay.

Sadhana Jackson

Sadhana Jackson is an American pediatric neuro-oncologist at NIH's NINDS who studies drug delivery across the blood-brain barrier and received a 2025 Presidential Early Career Award.

Sadistic personality disorder

Sadistic personality disorder, a proposed DSM-III-R appendix diagnosis (1987) of pervasive cruelty and lack of empathy, dropped from DSM-IV as insufficiently distinct from antisocial and narcissistic personality disorders; succeeded by trait sadism research in the Dark Tetrad.

Saethre-Chotzen syndrome

Saethre-Chotzen syndrome (SCS, acrocephalosyndactyly III, Chotzen syndrome) is an autosomal dominant craniosynostosis disorder caused by TWIST1 loss-of-function variants on chromosome 7p21, featuring coronal suture fusion, ptosis, small ears, and 2-3 syndactyly.