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Secondary cytoreductive surgery
Secondary cytoreductive surgery (SCRS) is an operation to remove recurrent ovarian cancer tumors after a first course of treatment, benefiting platinum-sensitive, limited-volume disease when complete resection is achieved.
Secondary dystonia
Secondary dystonia (ICD-11 8A02.1) is dystonia caused by another condition or external factor such as drugs, stroke, trauma, hypoxia, toxins, or heredodegenerative disease, distinguished from primary dystonia by rest-onset movements, hemidystonia, and other neurological signs.
Secondary eczema
Secondary eczema (id reaction, autoeczematisation, autosensitisation dermatitis; ICD-11 EA88.2/EA88.3) is eczematous dermatitis arising secondary to another skin disease, typically a widespread itchy eruption following a neglected lower-leg rash, infection, or contact dermatitis.
Secondary effect of trauma
Secondary effect of trauma (ICD-11 code ND57) is a residual injury category covering deformity NOS, old amputation, and scarring from previous injury, excluding PTSD and post-traumatic wound infection.
Secondary erythromelalgia
Secondary erythromelalgia (secondary erythermalgia) is burning pain, redness, and heat of the extremities caused by an underlying disorder, most often myeloproliferative disease, autoimmune conditions, infections, or drugs, relieved by cooling and often responsive to aspirin in blood disorders.
Secondary female infertility
Secondary female infertility (ICD-11 GA31.1) is infertility in a woman with at least one prior confirmed clinical pregnancy. Causes include tubal damage, ovulation disorders, endometriosis, fibroids, and prior pregnancy or surgical complications; it affects about 11% of US couples.
Secondary gout
Secondary gout, also called secondary hyperuricemia-related gout, is gout arising during another disease or from drugs, via purine overproduction, nucleic acid turnover, or reduced renal urate clearance; ICD-11 codes FA25.1 include lead- and drug-induced forms.
Secondary haemophagocytic lymphohistiocytosis
Secondary haemophagocytic lymphohistiocytosis (sHLH, secondary HLH): a life-threatening hyperinflammatory syndrome triggered by infection, malignancy, autoimmune disease, or drugs, diagnosed with HLH-2004 criteria or HScore and treated with trigger-directed immunosuppression.
Secondary headache
Secondary headache (ICD-11 8A84) is headache attributed to another causative disorder, spanning ICHD-3 categories 5-12 (trauma, vascular, infection, substances, and others). Distinguished from primary headache by red flags such as thunderclap onset, papilledema, and fever.
Secondary hyperaldosteronism
Secondary hyperaldosteronism (secondary aldosteronism): excess adrenal aldosterone driven by extra-adrenal RAAS activation from reduced renal blood flow, with high renin and aldosterone; causes include renal artery stenosis, heart failure, cirrhosis, nephrotic syndrome; treated by correcting the cause.
Secondary hypercholesterolaemia
Secondary hypercholesterolaemia (acquired hypercholesterolemia, ICD-11 5C80.01) is elevated LDL cholesterol caused entirely by another condition or drug, chiefly hypothyroidism, nephrotic syndrome, cholestasis, pregnancy, ketogenic or high-saturated-fat diets, and agents like thiazides, cyclosporine, and corticosteroids.
Secondary hypereosinophilic syndrome
Secondary hypereosinophilic syndrome (HES-R, reactive HES, ORPHA:314962) is a rare HES variant with polyclonal, cytokine-driven eosinophilia from infections, allergy, drugs, autoimmunity, or non-myeloid malignancy, persisting six months with organ damage.
Secondary hyperparathyroidism
Secondary hyperparathyroidism: excessive but non-autonomous parathyroid hormone production, chiefly from chronic kidney disease and vitamin D deficiency, driven by hypocalcemia, hyperphosphatemia, low calcitriol, and FGF23, and treated with phosphate binders, vitamin D analogs, calcimimetics, or parathyroidectomy.
Secondary hypertension
Secondary hypertension: high blood pressure from an identifiable cause (primary aldosteronism, sleep apnea, renal artery stenosis, renal disease, Cushing, pheochromocytoma). About 5–10% of hypertension overall, up to 30% in young adults; screened with aldosterone-to-renin ratio, metanephrines, imaging.
Secondary hyperthyroidism
Secondary (central) hyperthyroidism: raised free T4/T3 with non-suppressed TSH, caused by TSH-secreting pituitary adenoma (TSHoma) or resistance to thyroid hormone beta; distinguished from assay interference, treated by surgery and somatostatin analogs.
Secondary Immunization
Secondary immunization, or booster dosing, gives vaccine doses after a completed primary series to restore waning immunity or convert first-dose non-responders; CDC and WHO schedule boosters for tetanus, diphtheria, Hib, MMR, and COVID-19.
Secondary intestinal lymphangiectasia
Secondary intestinal lymphangiectasia (ORPHA:90363, ICD-10 I89.0) is acquired intestinal lymphangiectasia causing protein-losing enteropathy from another disorder such as Crohn's disease, congestive heart failure, or the Fontan operation; treatment targets the underlying disease.
Secondary intracranial hypotension
Secondary intracranial hypotension (ICD-11 8D61.1) is low CSF pressure, usually below 60 mm H2O, caused by an identified dural injury such as lumbar puncture, spinal or cranial surgery, shunt placement, or trauma, causing orthostatic headache.
Secondary lactase deficiency
Secondary lactase deficiency, or secondary lactose intolerance: loss of intestinal lactase from small bowel injury by infection (rotavirus, Giardia), celiac disease, Crohn's disease, surgery, chemotherapy, or radiation; usually reversible when the underlying cause is treated.
Secondary lichenification
Secondary lichenification (ICD-11 EA83.1): thickened, leathery skin with increased markings caused by repeated rubbing and scratching of skin already affected by a primary pruritic dermatosis such as atopic eczema, psoriasis, or lichen sclerosus.
Secondary lymphedema
Secondary lymphedema is swelling from acquired lymphatic drainage failure, accounting for roughly 85% of lymphedema worldwide, most often after cancer surgery, radiation, or filarial infection.
Secondary lymphoedema
Secondary lymphoedema, or acquired lymphedema, is limb or body swelling from lymphatic damage by cancer treatment, filariasis, trauma, or obesity; managed with decongestive therapy, compression, and microsurgery.
Secondary mood syndrome
Secondary mood syndrome (ICD-11 6E62; organic affective disorder) is prominent mood symptoms caused directly by a medical condition, coded with depressive, manic, mixed, or unspecified subtypes alongside the causing condition.
Secondary myocardial involvement of systemic disease
Secondary myocardial involvement of systemic disease is heart muscle dysfunction caused by an identifiable systemic condition, including endocrine, nutritional, electrolyte, iron-overload, and storage disorders rather than primary heart disease.
Secondary open-angle glaucoma
Secondary open-angle glaucoma: optic neuropathy with an open drainage angle caused by identifiable conditions such as pseudoexfoliation, pigment dispersion, neovascularization, trauma, inflammation, drugs, or lens-induced mechanisms, treated by lowering IOP plus addressing the cause.
Secondary pancreatic insufficiency
Secondary pancreatic insufficiency is a form of exocrine pancreatic insufficiency in which enzymes are released but cannot work, as after pancreatic or upper gastrointestinal surgery.
Secondary parkinsonism
Secondary parkinsonism (ICD-11 8A00.2) is parkinsonism caused by drugs, vascular disease, toxins, infection, trauma, or hydrocephalus rather than Parkinson disease; drug-induced parkinsonism is the most common cause and is often reversible.
Secondary peritonitis
Secondary peritonitis: acute peritoneal infection from loss of gastrointestinal tract integrity (perforated ulcer, appendicitis, diverticulitis, anastomotic leak), distinct from primary and tertiary peritonitis; polymicrobial, treated by surgical source control plus antibiotics.
Secondary personality change
Secondary personality change (ICD-11 6E68; ICD-10-CM F07.0, organic personality disorder) is a persistent personality change caused directly by a medical condition such as brain injury, tumor, or epilepsy, coded alongside the underlying disease.
Secondary portal hypertension
Secondary portal hypertension (ICD-11 DB98.74) is elevated portal venous pressure from an identifiable non-cirrhotic cause, classified prehepatic, intrahepatic, or posthepatic; includes left-sided (sinistral) portal hypertension from pancreatic disease, cured by splenectomy.