25,729 articles
Senior-Boichis syndrome
Senior-Boichis syndrome (Boichis disease, nephronophthisis-hepatic fibrosis syndrome, ORPHA:84081, OMIM 613550/616217) is a rare autosomal recessive ciliopathy combining nephronophthisis with liver fibrosis, sometimes retinal degeneration; TMEM67 and DCDC2 are associated genes.
SENIOR-RITA trial
SENIOR-RITA (Older Patients with NSTEMI Randomized Interventional Treatment), a UK randomized trial of 1,518 patients aged 75+ comparing invasive versus conservative NSTEMI management; invasive care did not reduce cardiovascular death or MI (25.6% vs 26.3%) over 4.1 years.
Senior–Løken syndrome
Senior–Løken syndrome (SLSN) is a rare autosomal recessive ciliopathy combining nephronophthisis with retinal dystrophy (Leber congenital amaurosis or retinitis pigmentosa), prevalence about 1 in 1,000,000, genes including NPHP1 and CEP290.
Senna glycoside
Senna glycosides (sennosides A, B, C, D), anthraquinone dianthrones from Senna alexandrina leaves and pods, are stimulant laxatives used short-term for constipation and bowel cleansing, acting via gut-bacterial conversion to rhein anthrone.
Sensation disturbance
Sensation disturbance (感覚障害), ICD-11 code MB40, is a symptom category covering lost, reduced, exaggerated, or abnormally perceived sensation, from anesthesia and analgesia to allodynia and dysesthesia, most often caused by sensory neuropathy.
Sense
A sense, also known as the five senses, is a biological system that detects stimuli through receptors and sends signals to the brain; humans have an estimated 22 to 33 senses.
SENSE trial
SENSE trial (NCT03316547): a randomized trial of 70 preterm infants at St. Louis Children's Hospital testing the Supporting and Enhancing NICU Sensory Experiences program, a parent-delivered daily sensory intervention, versus standard NICU care.
Sensitivity encoding (MRI)
Sensitivity encoding (SENSE) is a parallel MRI technique, introduced in 1999 by Pruessmann and colleagues, that uses receiver coil sensitivities to shorten scan times and remains widely used clinically.
Sensitization
Sensitization is a form of non-associative learning in which behavioral responses are amplified after an aversive or noxious stimulus, classically studied in the Aplysia gill- and siphon-withdrawal reflex.
Sensor-augmented insulin pump therapy
Sensor-augmented insulin pump (SAP) therapy combines an insulin pump with continuous glucose monitoring, dosing manually; it is a precursor of automated insulin delivery.
Sensorineural hearing loss
Sensorineural hearing loss (SNHL): inner ear hearing loss from damaged cochlear hair cells or auditory nerve fibers, caused by aging, noise, ototoxic drugs, Ménière's disease, or genetics; permanent, managed with hearing aids, cochlear implants, and now OTOF gene therapy.
Sensory Aids
Sensory aids are devices and materials that extend the senses, chiefly for visual or hearing impairment, including hearing aids, cochlear implants, low-vision aids, and cross-sensory substitution devices; MeSH D012682.
Sensory Art Therapies
Sensory Art Therapies (MeSH D026421, 2002): therapies using arts or directed at the senses, covering art, music, dance, play, color, aroma, and acoustic stimulation; evidence strongest for dementia dyads and state anxiety, weak for chronic pain.
Sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndrome
SANDO (sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndrome, ORPHA:70595) is a rare adult-onset autosomal recessive mitochondrial disease caused by POLG mutations, featuring ataxic neuropathy, dysarthria, and ophthalmoparesis; valproic acid is contraindicated.
Sensory Feedback
Sensory feedback: a organism's own sensory-system information about a task, movement, or skill (MeSH Feedback, Sensory). Covers proprioceptive and cutaneous sources, spinal sensorimotor circuits, intrinsic versus augmented feedback in motor learning, and wearable haptic feedback devices.
Sensory integration
Sensory integration is a framework and therapy approach describing how the brain organizes sensory input into adaptive responses, developed by A. Jean Ayres and used in occupational therapy.
Sensory nervous system
The sensory nervous system detects external and internal stimuli through receptors and relays them to the brain, generating touch, pain, vision, hearing, and other senses.
Sensory processing disorder
Sensory processing disorder (SPD), also called sensory integration dysfunction, is a proposed condition of atypical sensory modulation not recognized in DSM-5 or ICD-11; the AAP advises against diagnosing it, and sensory symptoms are instead features of autism and ADHD.
Sensory substitution
Sensory substitution delivers information from a lost sense (vision, hearing, balance) through another modality such as touch or sound; pioneered by Bach-y-Rita's 1969 TVSS, now including devices like BrainPort.
Sentinel lymph node
Sentinel lymph node: first node receiving drainage from a tumor, key to cancer staging. Examined via dye or radiotracer biopsy in breast cancer and melanoma; trials show lower morbidity than axillary dissection with equivalent survival.
Sentinel lymph node biopsy
Sentinel lymph node biopsy (SLNB), or sentinel node biopsy, is a surgical staging procedure that removes the first lymph node draining a tumor to check for cancer spread.
Seocalcitol
Seocalcitol (EB1089, CB-1089) is a synthetic vitamin D3 analogue and vitamin D receptor agonist developed by Leo Pharma as an anticancer drug, 50-200 times more potent than calcitriol in vitro with reduced calcemic toxicity; development was discontinued after phase II/III trials in hepatocellular, pancreatic, breast, and colorectal cancer.
Separation anxiety disorder
Separation anxiety disorder (SepAD): anxiety disorder with excessive fear of separation from attachment figures; DSM-5 (2013) removed the childhood-onset limit; lifetime prevalence 4.8%, 43.1% of onsets after age 18; treated with CBT and SSRIs.
Separation of retinal layers
Separation of retinal layers (ICD-10 H35.7; ICD-11 9B78.6) covers retinal detachment, retinoschisis, bacillary layer detachment, foveoschisis, and pigment epithelial detachment, distinguished by OCT layer-level findings.
Sepetaprost
Sepetaprost (ONO-9054, DE-126) is a dual FP/EP3 receptor agonist prodrug eye drop for glaucoma and ocular hypertension; phase 3 ANGEL-J1 showed IOP lowering non-inferior to latanoprost.
Sepiapterin
Sepiapterin (Sephience, PTC923) is an oral BH4-precursor drug for phenylketonuria, approved in the EU (June 2025) and US (July 2025); it lowers blood phenylalanine more than sapropterin in head-to-head trials.
Sepsis
Sepsis is life-threatening organ dysfunction from a dysregulated host response to infection, also called septicemia historically. GBD 2017 estimated 48.9 million cases and 11 million deaths, 19.7% of global deaths; treated with rapid antibiotics and fluids.
Sepsis in premature infants
Sepsis in premature infants (ORPHA:90051): life-threatening organ dysfunction from dysregulated infection response in babies born under 37 weeks; early-onset within 72 hours, late-onset to three months; Gram-negative pathogens now dominate.
Sepsis screening
Sepsis screening is the systematic use of vital-sign checks, early warning scores, or electronic alerts to identify possible sepsis early, so antibiotics and resuscitation begin promptly.
Sepsis without septic shock
Sepsis without septic shock (ICD-11 1G40) is life-threatening organ dysfunction from a dysregulated host response to infection, without the circulatory dysfunction defining septic shock (1G41).