25,729 articles
Serdexmethylphenidate
Serdexmethylphenidate (SDX), a prodrug of dexmethylphenidate, is the main component of Azstarys, a once-daily Schedule II capsule approved by FDA on March 2, 2021 for ADHD in patients 6 and older.
Serelaxin
Serelaxin (recombinant human relaxin-2) is an intravenous vasodilatory peptide drug trialed for acute heart failure in the RELAX-AHF and RELAX-AHF-2 trials, with conflicting mortality evidence.
SEREX
SEREX (serological analysis of recombinant cDNA expression libraries) is a tumor immunology method that screens tumor cDNA expression libraries with patient serum to identify tumor antigens like NY-ESO-1.
Serge Voronoff (Сергей Абрамович Воронов)
Serge Voronoff (Сергей Абрамович Воронов, 1866–1951), Russian-born French surgeon famous for the 1920s "monkey gland" operation grafting chimpanzee testis slices into aging men; claims of rejuvenation were unsubstantiated and the practice collapsed with the arrival of synthetic androgens.
Sergio Canavero
Sergio Canavero, Italian neurosurgeon of the Turin Advanced Neuromodulation Group, proposed HEAVEN head transplantation with GEMINI spinal cord fusion, announced a 2017 human operation in China with Xiaoping Ren, and faced broad scientific and ethical rejection.
Serial casting
Serial casting is a rehabilitation treatment in which successive casts progressively stretch a joint to increase range of motion, used mainly for contractures in cerebral palsy and spasticity.
Serial Extraction
Serial extraction (guidance of eruption) is an interceptive orthodontic procedure: planned sequential extraction of deciduous then first premolar teeth in mixed dentition to relieve severe arch crowding, requiring about 5 years of supervision and later fixed appliances.
Serial-position effect
Serial-position effect: memory depends on an item's position in a sequence, with primacy (early items) and recency (late items) advantages over middle items, producing the U-shaped free-recall curve first quantified by Murdock in 1962.
Serinflu
Serinflu: WHO-prequalified trivalent seasonal influenza vaccine (inactivated surface antigen) by Abbott Biologicals BV, Netherlands; 15 µg HA per strain per 0.5 ml dose, prequalified 25 May 2018, essentially similar to Influvac; distinct from quadrivalent Serinflu Tetra.
Serlopitant
Serlopitant (VPD-737, MK-0594) is an investigational oral NK1 receptor antagonist developed by Merck and Menlo Therapeutics for chronic itch; positive phase 2 pruritus and psoriasis trials but failed phase 3 prurigo and atopic dermatitis studies.
Sermorelin acetate
Sermorelin acetate (Geref), a 29-amino-acid GHRH analogue stimulating pituitary growth hormone release; FDA-approved 1990 and 1997, withdrawn 2009 for commercial reasons, now compounded only.
Seroconversion
Seroconversion, also called the appearance of detectable antibodies, is the change from antibody-negative to antibody-positive blood after infection or vaccination; its preceding window period (HIV 10–90 days by test type) governs HIV diagnosis and blood donor screening safety.
Serologic tests
Serologic tests, also called serological tests, are blood-based laboratory tests that detect antibodies or antigens in serum to diagnose infections, check immune status after vaccination, and identify autoimmune disease.
Serological testing
Serological testing detects antibodies or antigens in blood serum to diagnose infection, establish immune status, or document exposure, using methods such as ELISA, agglutination, and complement fixation.
Serology
Serology: laboratory study of blood serum antibodies to diagnose past infection, guide vaccination, and screen blood; includes IgM/IgG tests, immunoassays, and prevalence-dependent predictive values.
Seroma
Seroma: a pocket of serous fluid (plasma and lymph) collecting in a dead space, usually after surgery such as mastectomy, abdominoplasty, or hernia repair; often resolves spontaneously, otherwise aspirated, drained, or sclerosed.
Seronegative rheumatoid arthritis
Seronegative rheumatoid arthritis (SNRA): RA negative for rheumatoid factor and ACPA, 20-30% of cases; distinct genetics, diagnostic delays, erosive potential, and attenuated response to rituximab.
Seropositive rheumatoid arthritis
Seropositive rheumatoid arthritis: RA subset defined by rheumatoid factor and/or ACPA autoantibodies, about two-thirds of cases, more severe course, MHC class II-linked, lung-triggered, with distinct biologic treatment responses.
Seroprevalence survey
A seroprevalence survey is an epidemiological study measuring the proportion of a population with antibodies against a pathogen, capturing infections missed by case reporting; influenza antibody surveys date to the 1930s.
Serotonergic neuron
Serotonergic neurons synthesize and release serotonin (5-HT) from hindbrain raphe nuclei (B1–B9 groups), about 0.015% of rat brain neurons, with TPH2/SERT/VMAT2 phenotype, rostrocaudal subtypes, and forebrain-to-spinal cord projections.
Serotonin 5-HT2A receptor agonist
Serotonin 5-HT2A receptor agonists (5-HT2AR agonists; psychedelics such as LSD, psilocin, DMT, DOI, mescaline) activate the Gq-coupled 5-HT2A receptor in cortical layer V, producing psychedelic effects above a Gq efficacy threshold of about 70%.
Serotonin syndrome
Serotonin syndrome, or serotonin toxicity, is a potentially life-threatening drug-induced toxidrome from excess CNS serotonin, marked by neuromuscular excitation, autonomic hyperactivity, and altered mental status; severe cases usually involve MAOI plus SSRI combinations, diagnosed clinically via Hunter criteria and treated with supportive care and cyproheptadine.
Serotonin-producing neuroendocrine tumor of pancreas
Serotonin-producing neuroendocrine tumor of pancreas (pancreatic carcinoid, serotoninoma, ORPHA:506090): a rare functioning pancreatic NET secreting serotonin, causing atypical carcinoid syndrome, usually metastatic to liver, diagnosed by serum 5-HT or urinary 5-HIAA.
Serotonin–norepinephrine reuptake inhibitor
Serotonin–norepinephrine reuptake inhibitors (SNRIs), including venlafaxine, duloxetine, desvenlafaxine, milnacipran, and levomilnacipran, are antidepressants blocking serotonin and norepinephrine reuptake; used for depression, anxiety, and nerve pain.
Serous carcinoma of the corpus uteri
Serous carcinoma of the corpus uteri (uterine serous carcinoma, USC) is a rare, aggressive type II endometrial cancer, under 10% of cases but a large share of deaths, marked by TP53 mutation and treated with surgery plus chemotherapy.
Serous conjunctivitis, except viral
Serous conjunctivitis, except viral (ICD-10-CM H10.23; ICD-11 9A60.6) is a diagnostic classification for acute conjunctivitis with clear, watery discharge not attributed to a virus, coded by laterality subcodes H10.231-H10.239.
Serous cystadenocarcinoma of pancreas
Serous cystadenocarcinoma (SCAc) of the pancreas, also called serous cystic neoplasm with malignant transformation, is the rare malignant counterpart of serous cystadenoma, with fewer than 40 reported cases; it shows glycogen-rich clear cells, frequent liver metastasis, and relatively good survival after resection.
Serous detachment of retinal pigment epithelium
Serous detachment of retinal pigment epithelium (serous PED; ICD-10 H35.729, ICD-11 9B78.60) is serous fluid separating the RPE from Bruch membrane, seen mainly in neovascular AMD and central serous chorioretinopathy, diagnosed by OCT, with no proven treatment and RPE tear as the key complication.
Serous fluid
Serous fluid, or serosal fluid, is the clear, serum-like fluid secreted by serous membranes to lubricate the pleural, pericardial, and peritoneal cavities; its pathological buildup is called an effusion.
Serous retinal detachment
Serous retinal detachment (exudative retinal detachment, ICD-11 9B73.3): subretinal fluid separates the retina from the RPE without a break, caused by CSC, inflammation, tumors, or hypertension; treated medically.