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Spondylectomy
Spondylectomy is a spine surgical procedure that removes an entire affected vertebra, usually en bloc, to treat primary malignant or aggressive benign spinal tumors and selected metastases.
Spondylo-megaepiphyseal-metaphyseal dysplasia
Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD, OMIM 613330) is an ultra-rare autosomal recessive skeletal dysplasia caused by NKX3-2 loss-of-function mutations on 4p15.33, marked by delayed vertebral ossification, giant epiphyses, and pseudoepiphyses.
Spondylo-ocular syndrome
Spondylo-ocular syndrome (SOS, OMIM 605822), also called spondyloocular syndrome, is an autosomal recessive XYLT2-related skeletal and ocular disorder with osteoporosis, platyspondyly, cataract, retinal detachment, hearing loss, and cardiac defects.
Spondyloarthropathy
Spondyloarthropathy (spondyloarthritis, SpA) is a family of inflammatory rheumatic diseases affecting the spine and peripheral joints, including ankylosing spondylitis, psoriatic arthritis, and reactive arthritis, linked to HLA-B27, uveitis, psoriasis, and IBD.
Spondylocarpotarsal synostosis
Spondylocarpotarsal synostosis, also called congenital synspondylism, is a rare skeletal dysplasia in which fusion of spine, wrist, and ankle bones causes short stature and scoliosis; it is usually caused by FLNB gene mutations.
Spondylodysplastic Ehlers-Danlos syndrome
Spondylodysplastic Ehlers-Danlos syndrome (spEDS, spondylodysplastic EDS) is an ultra-rare autosomal recessive connective tissue disorder with B4GALT7, B3GALT6, or SLC39A13 subtypes, causing short stature, hypotonia, joint hypermobility, and skeletal anomalies.
Spondyloenchondrodysplasia
Spondyloenchondrodysplasia (SPENCD, SPENCDI) is a very rare autosomal recessive skeletal dysplasia caused by biallelic ACP5 mutations, causing platyspondyly, enchondromas, short stature, spasticity, cerebral calcifications, and autoimmunity.
Spondyloepimetaphyseal dysplasia with joint laxity, Beighton type
Spondyloepimetaphyseal dysplasia with joint laxity, Beighton type, also called SEMD-JL1, is a rare autosomal recessive skeletal disorder caused by B3GALT6 mutations, producing short stature, joint dislocations, and progressive kyphoscoliosis.
Spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type
Spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type (SEMDJL2) is a rare autosomal dominant skeletal dysplasia with short stature, multiple joint dislocations, and slender fingers and toes.
Spondyloepiphyseal dysplasia congenita
Spondyloepiphyseal dysplasia congenita (SEDC, SED congenita) is a rare COL2A1-related type II collagenopathy causing disproportionate short-trunk short stature, myopia, retinal detachment, hearing loss, and cervical instability, usually autosomal dominant and apparent at birth.
Spondyloepiphyseal dysplasia tarda
Spondyloepiphyseal dysplasia tarda (SEDT, SEDL, OMIM 313400) is a rare X-linked recessive skeletal dysplasia caused by TRAPPC2 mutations, causing late-onset short-trunk short stature, platyspondyly with vertebral humping, and precocious hip osteoarthritis in males.
Spondyloepiphyseal dysplasia, Kimberley type
Spondyloepiphyseal dysplasia, Kimberley type (SEDK, OMIM 608361) is a rare mild autosomal dominant skeletal dysplasia from ACAN (aggrecan) mutations, causing short stature, stocky build, and early-onset osteoarthritis of weight-bearing joints.
Spondylolisthesis
Spondylolisthesis: forward or other translation of one vertebra on another, graded I–V by the Meyerding system. Common forms are isthmic (pars defect, L5–S1) and degenerative (L4–L5, women over 65); nonoperative care is first-line.
Spondylolysis
Spondylolysis, a stress fracture defect of the pars interarticularis, usually at L5, is a leading cause of low back pain in adolescent athletes; treated first with bracing and physical therapy, surgery if refractory.
Spondylometaphyseal dysplasia-cone-rod dystrophy syndrome
Spondylometaphyseal dysplasia-cone-rod dystrophy syndrome (SMD-CRD, OMIM 608940) is a rare autosomal recessive disorder caused by PCYT1A mutations, combining platyspondyly, metaphyseal irregularity, severe short stature, and progressive cone-rod retinal dystrophy.
Spondylometaphyseal dysplasia, Kozlowski type
Spondylometaphyseal dysplasia, Kozlowski type (SMDK, OMIM 184252) is a rare autosomal dominant TRPV4-related skeletal dysplasia with short-trunk short stature, platyspondyly, kyphoscoliosis, and proximal femoral metaphyseal changes.
Spondylometaphyseal dysplasia, Sedaghatian type
Spondylometaphyseal dysplasia, Sedaghatian type (SSMD, OMIM 250220), also called lethal metaphyseal dysplasia, is a neonatal-lethal autosomal recessive GPX4-related skeletal dysplasia with platyspondyly, cardiac conduction defects, and CNS malformations.
Spondylosis
Spondylosis, or spinal osteoarthritis, is age-related degeneration of the spine's discs and facet joints, mainly cervical and lumbar; about 90% of adults over 60 have it, often without symptoms.
Spontaneous bacterial peritonitis
Spontaneous bacterial peritonitis (SBP), infection of ascitic fluid without an intra-abdominal source (PMN ≥250 cells/mm³), a complication of cirrhosis named by Harold Conn in 1964; treated with third-generation cephalosporins plus IV albumin, increasingly complicated by multidrug-resistant organisms.
Spontaneous breathing trial
A spontaneous breathing trial (SBT) is a bedside critical care test, usually lasting 30 to 120 minutes, that assesses whether a mechanically ventilated patient is ready for extubation.
Spontaneous heparin-induced thrombocytopenia
Spontaneous heparin-induced thrombocytopenia (SpHIT, spontaneous HIT syndrome) is a rare anti-PF4 disorder causing thrombocytopenia and thrombosis without heparin exposure, triggered by knee replacement surgery or infection, treated with non-heparin anticoagulation and IVIG.
Spontaneous human combustion
Spontaneous human combustion (SHC) is the alleged burning of a living human body without external ignition. Reported since the 17th century, it is explained forensically by the fat wick effect and was popularized by Dickens's Bleak House.
Spontaneous intestinal perforation
Spontaneous intestinal perforation (SIP), also called focal intestinal perforation, is an isolated bowel perforation in extremely low-birth-weight preterm newborns, usually within 10 days of birth, distinct from NEC and treated by peritoneal drain or laparotomy.
Spontaneous periodic hypothermia
Spontaneous periodic hypothermia, also called Shapiro syndrome or episodic spontaneous hypothermia, is a rare neurologic disorder of recurrent core-temperature drops below 35 °C with hyperhidrosis, without hypothalamic lesions; fewer than 1 per million prevalence, onset 6 months to 62 years.
Spontaneous remission
Spontaneous remission, or spontaneous regression of cancer, is the unexplained partial or complete disappearance of a malignant tumor without treatment. Documented since 1900 in about 1,000 cases; most frequent in melanoma, renal cell carcinoma, and neuroblastoma, often preceded by febrile infection.
Spontaneous rupture of oesophagus
Spontaneous rupture of oesophagus, or Boerhaave's syndrome, is a full-thickness oesophageal tear from vomiting or straining, first described by Boerhaave in 1724; treated by primary repair, endoscopy, or conservative care, with 16-18% mortality.
Spontaneous rupture of tendon
Spontaneous rupture of tendon, first named by Boyes in 1960, is the tearing of a weakened tendon under normal load without trauma, most often affecting the Achilles tendon.
Spontaneous tension pneumothorax
Spontaneous tension pneumothorax (ICD-11 CB21.0): air in the pleural space without trauma, with intrapleural pressure above atmospheric throughout respiration; rare in spontaneously breathing patients, treated by immediate decompression.
Spontaneous urticaria
Spontaneous urticaria (ordinary urticaria, ICD-11 EB00), including chronic spontaneous urticaria (CSU), is hives and angioedema arising without external triggers, unlike inducible urticaria; treated with second-generation H1-antihistamines, omalizumab, ciclosporin.
Spoon theory
Spoon theory, created by Christine Miserandino in 2003, is a chronic illness metaphor where spoons represent finite daily energy units; users called spoonies budget tasks, borrow against tomorrow, and risk crash days.