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Human health and medicine

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Squamous cell carcinoma of nasal cavity

Squamous cell carcinoma of the nasal cavity (NCSCC), also sinonasal SCC, is the most common sinonasal malignancy, linked to wood dust and other occupational carcinogens and partly to HPV; treated by surgery plus adjuvant radiotherapy, with about 50-55% five-year survival.

Squamous cell carcinoma of nasopharynx

Squamous cell carcinoma of nasopharynx (ICD-11 2B6B.0), also called nasopharyngeal carcinoma (NPC), is a malignant mucosal epithelial tumor of the nasopharynx with squamous differentiation; WHO subtypes keratinizing, non-keratinizing, basaloid; strongly EBV-linked, radiotherapy-treated.

Squamous cell carcinoma of palate

Squamous cell carcinoma of the palate (ICD-11 2B65.1) is SCC of the hard or soft palate. Hard palate SCC is about 2% of head and neck SCC; surgery is the mainstay; soft palate invasion worsens survival.

Squamous cell carcinoma of parotid gland

Squamous cell carcinoma of the parotid gland, primary parotid SCC, is a rare aggressive salivary malignancy; about 90% of parotid SCC is metastatic from cutaneous or mucosal head and neck primaries, making primary disease a diagnosis of exclusion.

Squamous cell carcinoma of scrotum

Squamous cell carcinoma of the scrotum (scrotal SCC, chimney sweep's cancer) is a rare male genital skin cancer, about 35% of scrotal malignancies, first linked to soot by Pott in 1775; 5-year relative survival is 77%.

Squamous cell carcinoma of skin

Squamous cell carcinoma of the skin (cutaneous squamous cell carcinoma, cSCC) is a cancer of epidermal squamous cells, usually sun-induced; second most common skin cancer after basal cell carcinoma, treated first with surgery and with anti-PD-1 immunotherapy when advanced.

Squamous cell carcinoma of the anal canal

Squamous cell carcinoma of the anal canal (SCCA), also called epidermoid anal cancer, is the most common anal cancer, 95% HPV-related (types 16, 18). Treated since the 1974 Nigro protocol with sphincter-preserving 5-FU/mitomycin chemoradiation; surgery is salvage.

Squamous cell carcinoma of the base of the tongue

Squamous cell carcinoma of the base of the tongue (ICD-11 2B6I.0) is an oropharyngeal cancer of the posterior tongue third, strongly linked to HPV16, often neck-node positive at diagnosis, treated with transoral surgery or chemoradiation, with better survival when HPV-positive.

Squamous cell carcinoma of the cervix uteri

Squamous cell carcinoma of the cervix uteri, also called cervical squamous cell carcinoma or epidermoid carcinoma (ICD-O 80703), is the most common cervical cancer type, arising from HPV-driven transformation of ectocervical squamous cells at the transformation zone.

Squamous cell carcinoma of the colon

Squamous cell carcinoma of the colon (colorectal SCC, ORPHA:423994) is an extremely rare colonic squamous-cell cancer, 0.1-0.25 per 1,000 colorectal carcinomas, diagnosed by excluding anal extension, fistulas, and metastasis, with worse survival than rectal SCC.

Squamous cell carcinoma of the corpus uteri

Squamous cell carcinoma of the corpus uteri (endometrial squamous cell carcinoma, ICD-O 8070/3) is a rare uterine cancer, under 0.5% of endometrial carcinomas, affecting postmenopausal women with discharge, bleeding, pain, often with cervical stenosis and pyometra.

Squamous cell carcinoma of the esophagus

Squamous cell carcinoma of the esophagus is a cancer of the flat cells lining the esophagus, causing about 85 to 90 percent of esophageal cancers worldwide.

Squamous cell carcinoma of the lip

Squamous cell carcinoma of the lip (lip SCC), a head and neck cancer usually arising at the lower-lip vermilion border; over 25% of oral cancers, mainly older white men, treated mostly by surgery, with 9% mean occult metastasis rate.

Squamous cell carcinoma of the oral cavity

Squamous cell carcinoma of the oral cavity (OSCC, oral cavity SCC), the most common oral malignancy; tobacco, alcohol, and betel quid are main risk factors; treated mainly by surgery with neck dissection and adjuvant radiotherapy.

Squamous cell carcinoma of the penis

Squamous cell carcinoma of the penis (PSCC) is the dominant penile malignancy, over 95% of cases, arising from glans or inner prepuce epithelium; about 40% are HPV-associated (mainly HPV 16), classified by the 2022 WHO as HPV-associated or HPV-independent, with survival strongly tied to nodal status.

Squamous cell carcinoma of the rectum

Squamous cell carcinoma of the rectum (rectal SCC, rSCC) is a rare squamous-differentiated rectal cancer, under 1% of rectal tumors, defined by the Williams criteria, treated mainly with definitive chemoradiation, with worse survival than anal SCC.

Squamous cell carcinoma of the small intestine

Squamous cell carcinoma of the small intestine (SCC-SI), an extremely rare malignant epithelial tumor, usually duodenal; roughly 27 primary cases reported, arising via metaplasia or ectopic epithelium, with median survival about six months.

Squamous cell carcinoma of the stomach

Squamous cell carcinoma of the stomach, also called primary gastric squamous cell carcinoma, is a very rare stomach cancer, accounting for under 0.5 percent of cases.

Squamous cell carcinoma of tonsil

Tonsillar squamous cell carcinoma (TSCC), tonsil cancer: oropharyngeal SCC, about half HPV-16 positive, 71-89% nodal spread, treated with radiotherapy, transoral surgery, or chemoradiation; HPV-positive disease has better survival.

Squamous cell carcinoma of trachea

Squamous cell carcinoma of trachea (ICD-11 2C24.1), the most common primary tracheal cancer; smoking-related, male-predominant, aggressive; 5-year overall survival about 25%, better with curative surgery or chemoradiation.

Squamous cell carcinoma of urinary bladder

Squamous cell carcinoma of urinary bladder (ICD-11 2C94.1), a keratin-forming bladder cancer from metaplastic epithelium; 2–5% of Western bladder tumors, schistosomiasis-linked in endemic regions, treated by radical cystectomy.

Squamous cell carcinoma of vagina

Squamous cell carcinoma of vagina (ICD-11 2C71.2; ICD-10 C52) is the most common vaginal cancer, about 80-90% of cases, usually HPV-driven, treated mainly with surgery or radiation.

Squamous-cell carcinoma

Squamous-cell carcinoma (SCC, epidermoid carcinoma) is cancer of squamous cells in skin and organ linings; cutaneous SCC is the second most common skin cancer, cured in over 90% of early cases, treated by excision or anti-PD-1 immunotherapy when advanced.

Squat (exercise)

Squat (exercise): compound lower-body resistance exercise flexing hips, knees, and ankles; works quadriceps, glutes, hamstrings. Variants include back, front, goblet, and chair squats; deep squats are safe with proper technique.

Squatting position

Squatting position: a resting, working, toileting, and exercise posture with deeply flexed knees and hips; used by at least a fourth of humanity, defined by knee flexion angles, and reviewed for knee safety.

Squid giant synapse

Squid giant synapse: large glutamatergic synapse in the squid stellate ganglion's giant fiber system (escape circuit), classical preparation that established calcium-triggered, quantal, nanodomain-coupled neurotransmitter release.

Squid-sucker adhesive patch

A squid-sucker adhesive patch is a bioinspired medical adhesive that borrows squid sucker ring teeth or cephalopod suction-cup architecture to bond to wet, soft tissue.

SRD5A3-CDG

SRD5A3-CDG (formerly CDG type Iq, OMIM 612379) is a rare autosomal recessive glycosylation disorder from SRD5A3 gene variants blocking polyprenol-to-dolichol conversion, causing early vision loss, intellectual disability, hypotonia, and ataxia.

Srihari S. Naidu

Srihari S. Naidu is an American interventional cardiologist known for hypertrophic cardiomyopathy and alcohol septal ablation, directing the HCM Program at Westchester Medical Center in Valhalla, New York.

Srnga bhasma

Srnga bhasma (Shringa Bhasma, Mrigashringa Bhasma, शृङ्ग भस्म) is an Ayurvedic calcined deer horn ash, a calcium-rich white powder used as an expectorant and bone tonic, prepared by shodhana and repeated puta incineration per Rasa Tarangini 12/105-107.