Human health and medicine

SRSD107

SRSD107: investigational long-acting GalNAc siRNA by Sirius Therapeutics (靖因药业) targeting factor XI mRNA for anticoagulation; Phase 2 VTE and CAD/PAD trials, co-developed with CRISPR Therapeutics.

SRSD216

SRSD216 is an investigational Lp(a)-lowering siRNA from Sirius Therapeutics targeting LPA mRNA; Phase 1 single doses cut Lp(a) up to 94.7% with effects lasting over seven months.

SS-HCC (NCT00495846), a completed 2007-2008 Federico II University of Naples pilot phase 2/3 trial testing depot octreotide-LAR and lanreotide Autogel in 25 patients with advanced somatostatin receptor-expressing hepatocellular carcinoma; no results posted.

SSGJ-707 (PF-08634404), PD-1/VEGF bispecific antibody

SSGJ-707, renamed PF-08634404, is 3SBio's tetravalent IgG4 PD-1/VEGF bispecific antibody built on the CLF2 platform; licensed to Pfizer ex-China in 2025 for $1.25 billion upfront, with phase 2 NSCLC ORR 67.6% and phase 3 trials ongoing.

Oct 22, 2026

ssPalm

ssPalm is a gemini ionizable lipid for intracellular delivery of nucleic acids, developed by Hidetaka Akita's group in Japan, whose particles escape endosomes and release cargo on disulfide cleavage.

SSR4-CDG

SSR4-CDG (CDG1Y, congenital disorder of glycosylation type Iy) is an ultra-rare X-linked recessive disorder caused by SSR4 gene variants at Xq28 disrupting the TRAP complex and N-linked glycosylation, causing developmental delay, hypotonia, microcephaly, and distinctive facial features.

ST depression

ST depression: an ECG finding where the ST segment sits below baseline, measured at the J point. Mainly a marker of myocardial ischemia (NSTE-ACS, posterior STEMI), but also caused by LBBB, LVH, digoxin, hypokalemia, and tachycardia.

ST elevation

ST elevation: ECG finding of an elevated ST segment measured at the J point; defines STEMI at ≥1 mm in 2 contiguous leads (higher V2-V3 cut-points) but also occurs in pericarditis, early repolarization, LBBB, LVH, and other mimics.

St James's University Hospital

St James's University Hospital ("Jimmy's") is a large NHS teaching hospital on Beckett Street, Leeds, run by Leeds Teaching Hospitals NHS Trust; it grew from an 1840s workhouse, expanded in the 1970s, and houses the Leeds Cancer Centre in the Bexley Wing.

St Mark's Hospital

St Mark's Hospital is a London hospital specializing entirely in intestinal and colorectal medicine. Founded in 1835 by Frederick Salmon, it is now based at Central Middlesex Hospital, Park Royal.

St Mary's Hospital, London

St Mary's Hospital, Paddington, London: NHS acute hospital founded 1845, opened 1851, run by Imperial College Healthcare NHS Trust; home of London's busiest major trauma centre, Fleming's penicillin discovery, and a planned £2.2bn 800-bed rebuild.

St Thomas' Hospital

St Thomas' Hospital is a large NHS teaching hospital in Lambeth, London, opposite the Palace of Westminster, with 840 beds and a history dating back to 1173.

ST-elevation myocardial infarction

ST-elevation myocardial infarction (STEMI) is a heart attack producing ST-segment elevation on the ECG, making up 25% to 40% of US heart attacks and requiring reperfusion within 12 hours.

St. Elizabeth's Medical Center

St. Elizabeth's Medical Center, Boston (Brighton), founded 1868/69 as St. Elizabeth's Hospital for Women; teaching hospital under Steward Health Care, seized by eminent domain in 2024, now Boston Medical Center – Brighton.

St. Joseph's Hospital

St. Joseph's Hospital, St. Paul, Minnesota, founded 1853 by the Sisters of St. Joseph of Carondelet, was Minnesota's first hospital; it closed as a general hospital in 2020 and became Fairview's Community Health and Wellness Hub. Other hospitals share the name.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital, founded by Danny Thomas in Memphis in 1962, is a nonprofit pediatric cancer research hospital where families never receive bills; ALSAC raised over $2.5 billion in 2024.

St. Louis encephalitis

St. Louis encephalitis: mosquito-borne flavivirus disease (SLEV) spread by Culex mosquitoes from birds; identified in the 1933 St. Louis epidemic; no vaccine or specific treatment; mostly U.S. cases.

St. Luke's Hospital

St. Luke's Hospital, Bradford: NHS hospital on Little Horton Lane (BD5 0NA) run by Bradford Teaching Hospitals NHS Foundation Trust, providing outpatient and rehabilitation services; a former 1852 workhouse and England's first municipal general hospital (1920).

ST2-IPF trial

ST2-IPF: sit-to-stand exercise testing in idiopathic pulmonary fibrosis, anchored by trial NCT03268915 (3-minute test reproducibility, Grenoble/Lyon) and validation studies comparing 1-min, 3-min, and 5-repetition protocols with the 6-minute walk test.

STA trial

STA trial (SPTSS, NCT01837433): a phase 4 randomized trial at Xinqiao Hospital, Chongqing, testing 1 week of prednisone plus NSAIDs versus 6-week prednisone for moderate-to-severe subacute thyroiditis, finding similar efficacy with fewer side effects.

STABILITY trial (NCT00799903)

STABILITY (NCT00799903), Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy: phase 3 GlaxoSmithKline trial of darapladib 160 mg daily in 15,828 stable coronary heart disease patients; Lp-PLA2 lowered ~65% but primary endpoint (cardiovascular death, MI, stroke) not reduced (HR 0.94).

Stabilometry

Stabilometry is a clinical assessment method that quantifies postural sway in standing subjects with a force platform, used in evaluating vestibular deficit and fall risk.

Stable angina

Stable angina (angina pectoris) is predictable chest pain from heart-muscle oxygen shortage, usually coronary artery disease, triggered by exertion or stress, relieved by rest or nitroglycerin, and treated with beta blockers, calcium channel blockers, and prevention drugs.

Stacey Yuxin Ma

Stacey Yuxin Ma is a chemical engineer who leads pharmaceutical development and manufacturing at Gilead Sciences and was elected to the National Academy of Engineering in 2026.

Stage fright

Stage fright: performance-context anxiety driven by sympathetic-adrenal activation (adrenaline, noradrenaline, cortisol). Affects 16.5-60% of professional musicians; treated with CBT, exposure, and beta-blockers; distinct from glossophobia and generalized social anxiety.

Staged excision

Staged excision is a surgical technique that removes a skin tumor layer by layer, with each specimen examined microscopically, used mainly for melanoma in situ such as lentigo maligna.

Staging laparoscopy

Staging laparoscopy is a minimally invasive surgical procedure that inspects the abdomen with a laparoscope and takes biopsies to detect hidden cancer spread before planned curative surgery.

Staging laparotomy

A staging laparotomy is an operation opening the abdomen to inspect and biopsy cancer directly, converting clinical stage into pathologic stage based on tissue findings.

Stair Climbing

Stair climbing, ascending or descending stairs, is a vigorous daily physical activity and MeSH-indexed exercise mode. Climbing burns about 20 times more calories than flat walking, and meta-analyses link regular stair use to roughly 35% lower cardiovascular mortality.