25,729 articles
TAACS trial
TAACS (Thiamine Administration After Cardiac Surgery Trial, NCT04641104) is a completed Belgian phase 4, double-blind trial of 500 mg post-operative thiamine versus placebo for lactate clearance after cardiac surgery; no results posted.
TAAG trial
TAAG (Trial of Activity in Adolescent Girls), NHLBI-sponsored group-randomized trial of 36 US middle schools, 2000-2006, testing a school-community intervention to halve the decline in girls' moderate-to-vigorous physical activity; modest effect (10.9 MET-min/day) after the Program Champion year.
Tabalumab
Tabalumab (LY2127399) is Eli Lilly's human IgG4 monoclonal antibody neutralizing soluble and membrane-bound BAFF. Its Phase 3 rheumatoid arthritis and lupus (ILLUMINATE) programs failed on efficacy, and development stopped in October 2014.
Tabes dorsalis
Tabes dorsalis (locomotor ataxia) is a rare late form of neurosyphilis from Treponema pallidum, causing demyelination of spinal posterior columns, lightning pains, ataxia, and Argyll Robertson pupils decades after infection.
Tablet (pharmacy)
Tablet (pharmacy): compressed solid oral dosage form of an API plus excipients; two-thirds of the global drug market; first made by William Brockeden in 1844; types include immediate-release, modified-release, and orally disintegrating tablets.
Tacabrutideg
Tacabrutideg (BGB-16673) is BeOne Medicines' oral BTK-targeted chimeric degradation activating compound (CDAC/PROTAC) degrading wild-type and mutant BTK via cereblon, in Phase 3 trials for R/R CLL/SLL with FDA Fast Track and EMA PRIME designations.
Tacalcitol
Tacalcitol (Bonalfa, TV-02), 1alpha,24-dihydroxyvitamin D3, is a topical vitamin D3 analog ointment (4 microg/g once daily) for psoriasis vulgaris, first approved in Japan in 1993; less effective than calcipotriol but less irritant, also used on the scalp and with NBUVB phototherapy.
Tacedinaline
Tacedinaline (CI-994, acetyldinaline, GOE5549, PD 123654) is an orally bioavailable benzamide histone deacetylase inhibitor developed by Pfizer for lung and pancreatic cancer and myeloma; it reached phase III trials but was discontinued and never approved.
Tachyarrhythmias in pregnancy
Tachyarrhythmias in pregnancy are abnormally rapid heart rhythms, including supraventricular tachycardia, atrial fibrillation or flutter, and ventricular tachycardia, that occur during pregnancy or early postpartum, affecting 0.03% to 0.5% of pregnancies.
Tachycardia
Tachycardia, or tachyarrhythmia, is a resting heart rate above 100 beats per minute. Supraventricular types start in the atria, ventricular types in the ventricles; causes, diagnosis, and treatments including ablation and ICDs are covered.
Tachycardia-induced cardiomyopathy
Tachycardia-induced cardiomyopathy (tachycardiomyopathy, TIC) is reversible heart failure caused by chronic or recurrent rapid heart rhythms such as atrial fibrillation; systolic function recovers after rate or rhythm control, but recurrence risks rapid decline and sudden death.
Tachykinin family
Tachykinin family, or neurokinins: peptide neurotransmitters sharing the C-terminal Phe-X-Gly-Leu-Met-NH2 motif, including substance P, neurokinin A, and neurokinin B, acting through NK1, NK2, and NK3 GPCRs across vertebrates and invertebrates.
Tachypnea
Tachypnea is rapid breathing above the age-normal respiratory rate (adults over 20 breaths per minute, newborns over 60). It occurs physiologically in exercise, fever, and pregnancy, and signals conditions like sepsis, pneumonia, and diabetic ketoacidosis.
Tacrolimus
Tacrolimus (FK506, Prograf) is a macrolide calcineurin-inhibitor immunosuppressant from Streptomyces tsukubaensis, first used in humans in 1989; it outperforms cyclosporine for graft survival but causes more post-transplant diabetes.
Tactical Combat Casualty Care
Tactical Combat Casualty Care (TCCC) is a set of prehospital trauma care guidelines for combat and hostile environments, dividing care into three phases and prioritizing hemorrhage control.
Tactile hallucinations
Tactile hallucinations, also called haptic hallucinations, are perceptions of touch without a stimulus; formication (insect crawling, from Latin formica) is the best-known form, occurring in schizophrenia, Parkinson's disease, substance use, and medical conditions.
Tadalafil
Tadalafil (Cialis, Adcirca) is a long-acting PDE5 inhibitor approved in 2003 for erectile dysfunction, later for BPH and PAH, with a 17.5-hour half-life and a 48-hour nitrate interaction window.
Tadekinig alfa
Tadekinig alfa (IL-18BP, tadekinig-alfa) is a recombinant human interleukin-18 binding protein by AB2 Bio that neutralizes IL-18, tested in phase II AOSD and completed phase III NLRC4 mutation and XIAP deficiency trials, with FDA orphan drug designation.
TADPOL trial
TADPOL (TArgeting Type 1 Diabetes Using POLyamines, NCT05594563) is a phase 2 US trial of oral DFMO 1000 mg/m2/day vs placebo in ages 4-40 within 100 days of T1D diagnosis; 74 enrolled, results due June 2027.
Tae Bo
Tae Bo, created by Billy Blanks, is a cardio workout blending taekwondo and boxing with aerobics. Its 1998 video sold over 5 million copies, sparked the cardio kickboxing boom, and burns 350-450 calories per hour.
TAES trial
TAES trial (NCT06718231, TAES Alleviate Post-VATS Depression) is a not-yet-recruiting randomized trial testing transcutaneous electrical acupoint stimulation versus sham for depression after video-assisted thoracoscopic surgery.
Tafamidis
Tafamidis (Vyndaqel, Vyndamax, Pfizer) is an oral TTR kinetic stabilizer for transthyretin amyloidosis; approved in the EU in 2011 for polyneuropathy and by the FDA in 2019 as first therapy for ATTR-CM, proven in ATTR-ACT.
Tafasitamab
Tafasitamab (Monjuvi, Minjuvi) is an Fc-engineered humanized anti-CD19 monoclonal antibody approved with lenalidomide for relapsed/refractory DLBCL (US 2020, EU 2021) and with lenalidomide plus rituximab for follicular lymphoma (2025).
Tafenoquine
Tafenoquine (Krintafel, Kozenis, Arakoda, Kodatef; WR 238605) is a long-acting 8-aminoquinoline antimalarial, a primaquine analogue discovered by the U.S. Army in 1978, FDA-approved in 2018 for weekly malaria prophylaxis and single-dose radical cure of Plasmodium vivax malaria, contraindicated in G6PD deficiency.
Tafluprost
Tafluprost (AFP-168; brand ZIOPTAN) is a preservative-free fluorinated prostaglandin F2α analogue eye drop, 0.0015%, approved in 2012 to lower intraocular pressure in open-angle glaucoma and ocular hypertension via FP receptor agonism.
Tafolecimab
Tafolecimab (IBI 306, SINTBILO) is Innovent Biologics' fully human IgG2 anti-PCSK9 monoclonal antibody for hypercholesterolemia; NMPA approved it in August 2023 as China's first domestic PCSK9 antibody, with CREDIT trials showing 57-65% LDL-C reductions.
Tagitanlimab (KL-A167)
Tagitanlimab (KL-A167, A167, HBM-9167; brand Cotelet, 塔戈利单抗) is Kelun-Biotech's humanized IgG1κ anti-PD-L1 antibody, NMPA-approved in China (Dec 2024, Jan 2025) for recurrent/metastatic nasopharyngeal carcinoma, monotherapy and first-line with cisplatin-gemcitabine.
Tagraxofusp
Tagraxofusp (Elzonris, SL-401, DT388IL3) is a CD123-directed cytotoxin fusing interleukin-3 to truncated diphtheria toxin; first FDA-approved (2018) treatment for blastic plasmacytoid dendritic cell neoplasm, with capillary leak syndrome as its key toxicity.
Taipei Veterans General Hospital
Taipei Veterans General Hospital (臺北榮民總醫院, 北榮) is a public veterans medical center in Beitou, Taipei, founded 1958, with 3,136 beds, 7,116 staff, branches across Taiwan, and sister hospitals in Taichung and Kaohsiung.
Taiping Shenghui Fang
太平圣惠方 (Taiping shenghui fang), the first large official Song formulary, compiled 978–992 under Emperor Taizong by Wang Huaiyin and others; 100 juan, 1,670 sections, 16,834 prescriptions, widely circulated in China, Korea, and Japan.