25,729 articles
Tariquidar
Tariquidar (XR9576) is a third-generation anthranilamide inhibitor of the P-glycoprotein (ABCB1) drug efflux pump, acting noncompetitively via ATPase inhibition; clinically tested in cancer trials that were halted, now used in P-gp research and PET imaging.
TARLATEM trial
TARLATEM (NCT07243470, ET23-040) is a Centre Léon Bérard phase I/II trial of tarlatamab (AMG 757), a DLL3×CD3 bispecific, plus metronomic temozolomide in DLL3-positive high-grade CNS tumors, distinct from the DeLLphi-301 SCLC trial.
Tarlov cyst
Tarlov cyst (perineural cyst): CSF-filled sac around sacral spinal nerve roots containing nerve fibers, first described by Isadore Tarlov in 1938; prevalence 1.5–13.2%, symptomatic in 10–20%, treated by surgery or fibrin-sealant aspiration.
TARP syndrome
TARP syndrome, an X-linked recessive disorder from RBM10 loss-of-function mutations, causes talipes equinovarus, atrial septal defect, Robin sequence, and persistent left superior vena cava; historically lethal in male infants, with rare long-term survivors. Distinct from TAR syndrome (RBM8A).
Tarrare
Tarrare (c. 1772–1798), French showman, soldier, and spy with extreme polyphagia; known only through Pierre-François Percy's 1804 memoir, swallowed documents as a courier, suspected in a toddler's disappearance, died of tuberculosis in Versailles.
Tarsal kink syndrome
Tarsal kink syndrome (ORPHA:99170), a rare congenital eyelid disorder: a horizontal kink in the upper tarsal plate causing upper lid entropion, blepharospasm, absent eyelid crease, and risk of corneal ulceration, treated surgically.
Tarsal tunnel syndrome
Tarsal tunnel syndrome, also called posterior tibial neuralgia or tibial nerve entrapment, is compression of the posterior tibial nerve in the tarsal tunnel at the ankle, defined by Keck and Lam in 1962, causing foot pain and numbness, treated conservatively or by flexor retinaculum release.
Tarsal-carpal coalition syndrome
Tarsal-carpal coalition syndrome (TCC, NOG-SSD) is a rare autosomal dominant NOG-gene bone disorder fusing carpals, tarsals, and phalanges, starting in the fifth digits, with neonatal onset, humeroradial fusion, and prevalence under 1 per million.
Tarsus (skeleton)
Tarsus (skeleton): the seven tarsal bones of the human foot (calcaneus, talus, cuboid, navicular, three cuneiforms), their joints, gait biomechanics, historical names, and accessory ossicles.
Taselisib
Taselisib (GDC-0032, RG7604) is a Genentech beta-sparing PI3K inhibitor (alpha, delta, gamma) tested in PIK3CA-mutated breast cancer; the phase III SANDPIPER trial met its endpoint but toxicity and modest benefit ended development, and it was never approved.
Tasimelteon
Tasimelteon (Hetlioz) is a dual melatonin MT1/MT2 receptor agonist approved by the FDA in 2014 for non-24-hour sleep-wake disorder in blind adults and later for Smith-Magenis syndrome sleep disturbances.
Tasisulam
Tasisulam (LY573636), an Eli Lilly acyl-sulfonamide anticancer agent, induces mitochondrial apoptosis, antiangiogenesis, and RBM39 degradation via DCAF15 molecular glue action; halted after phase 3 melanoma safety deaths.
Tasonermin
Tasonermin (Beromun) is recombinant human TNF alfa-1a from E. coli, EU-approved 1999, given with melphalan by isolated limb perfusion to treat limb soft-tissue sarcoma and avoid amputation.
Taspoglutide
Taspoglutide (BIM-51077, R-1583), a once-weekly GLP-1 receptor agonist from Ipsen licensed to Roche for type 2 diabetes; effective in T-emerge phase 3 trials but abandoned in 2010 over GI intolerance, antibodies, and anaphylaxis.
Tasquinimod
Tasquinimod (ABR-215050, TASQ) is an oral quinoline-3-carboxamide immunomodulator targeting S100A9 and HDAC4; phase III in prostate cancer improved PFS but not survival, and it is now in myelofibrosis trials.
Taste
Taste (gustation) is the chemical sense detecting sweet, sour, salty, bitter, and umami via taste bud receptor cells; also covers transduction, TAS2R38 genetics, PROP/PTC heritability, oleogustus, taste disorders, and penguin taste loss.
Taste bud
Taste bud: cluster of 50-100 neuroepithelial cells in tongue, palate, and throat papillae that transduces sweet, sour, salty, bitter, and umami stimuli; 2,000-5,000 per human oral cavity, continually renewed.
Taste receptor
Taste receptor: receptor proteins on taste receptor cells detecting bitter, sweet, umami, salty, and sour tastants. T1R and T2R GPCR families; TAS1R2+TAS1R3 sweet receptor; TAS2R14 structure solved 2024; also expressed in gut, lungs, heart, brain.
Tata Memorial Centre
Tata Memorial Centre (TMC), also called Tata Memorial Hospital, is India's national cancer centre, a Department of Atomic Energy grant-in-aid institute in Mumbai founded in 1941, now an eleven-hospital network spanning seven states.
Tatton-Brown-Rahman syndrome
Tatton-Brown-Rahman syndrome (DNMT3A overgrowth syndrome, TBRS) is a rare autosomal dominant disorder caused by DNMT3A variants, causing overgrowth, mild-to-severe intellectual disability, hypotonia, joint hypermobility, autism features, and possible leukemia risk.
Taurolidine
Taurolidine (taurolin) is a taurine-derived thiadiazinane antimicrobial used in catheter lock solutions to prevent catheter-related bloodstream infections; FDA approved as Defencath with heparin in 2023 for adult hemodialysis patients.
Tavaborole
Tavaborole (Kerydin, AN2690) is an oxaborole topical antifungal, 5% solution, FDA approved 2014 for toenail onychomycosis from T. rubrum or T. mentagrophytes; inhibits aminoacyl-tRNA synthetase, applied daily 48 weeks.
Tavapadon
Tavapadon (PF-06649751, CVL-751; brand Juvmo) is an oral once-daily selective D1/D5 partial dopamine agonist for Parkinson disease in adults, FDA approved 2026 after the TEMPO-1 to TEMPO-4 phase 3 trials.
Tavilermide
Tavilermide (MIM-D3) is an investigational cyclic peptidomimetic of NGF and partial TrkA agonist eye drop for dry eye disease, developed by Mimetogen and licensed to Allergan; not approved, with mixed phase 3 results.
Tax Equity and Fiscal Responsibility Act
Tax Equity and Fiscal Responsibility Act of 1982 (TEFRA), Public Law 97-248: US budget law whose Medicare title created HMO risk contracting at 95 percent of AAPCC, TEFRA hospital target amounts, and the PRO peer review program.
Taxis (medicine)
Taxis is the reduction of a displaced body part, such as an incarcerated hernia or dislocated joint, to its normal anatomical position by manual manipulation alone, without surgery.
Tay–Sachs disease
Tay–Sachs disease, a fatal autosomal recessive GM2-gangliosidosis caused by HEXA gene variants on chromosome 15 lacking hexosaminidase-A; infantile form kills by age five, carriers common in Ashkenazi Jews, no cure, gene therapy in trials.
Tazarotene
Tazarotene (Tazorac, Arazlo) is an acetylenic topical retinoid prodrug converted to tazarotenic acid, selective for RARβ/RARγ, approved since 1997 for plaque psoriasis and acne vulgaris, contraindicated in pregnancy.
Tazemetostat
Tazemetostat, sold as Tazverik, is a first-in-class, orally active inhibitor of the methyltransferase EZH2 approved in 2020 for epithelioid sarcoma and follicular lymphoma, withdrawn in 2026 over secondary blood cancers.
TB-500
TB-500, also called thymosin beta-4 fragment or Ac-LKKTETQ, is a synthetic seven-amino-acid peptide (residues 17-23 of thymosin beta-4) sold as a research chemical, untested in human trials, and WADA-prohibited under S2.3.