25,729 articles
Triclosan
Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) is a chlorinated diphenyl ether antimicrobial inhibiting bacterial FabI, used in toothpastes and formerly consumer antibacterial soaps, banned by FDA in 2016.
TRICS-9 trial
TRICS-9 (NCT04400981) is an Italian phase II randomized trial of remote ischemic conditioning, four 5-minute blood pressure cuff inflation cycles on the non-paretic arm, for acute ischemic stroke within 9 hours in patients ineligible for thrombolysis or thrombectomy.
Tricuspid atresia
Tricuspid atresia is a critical congenital heart defect in which the tricuspid valve never forms, blocking right atrial to right ventricular flow. Treated with staged palliation ending in the Fontan procedure; about 1 in 12,500 US births.
Tricuspid regurgitation
Tricuspid regurgitation, also known as tricuspid insufficiency, is a right-sided heart valve disease in which the tricuspid valve fails to close fully, letting blood leak backward.
Tricuspid valve
Tricuspid valve (right atrioventricular valve): heart valve between right atrium and right ventricle with three leaflets, chordae tendineae, and the largest cardiac orifice (7-9 cm2); main disease is tricuspid regurgitation, treated by diuretics, surgery, or transcatheter repair/replacement.
Tricuspid valve replacement
Tricuspid valve replacement is a cardiac surgery procedure in which a diseased tricuspid valve is replaced with a prosthetic valve, used only when repair is not feasible or has failed.
Tricuspid valve rupture
Tricuspid valve rupture: traumatic tearing of the right heart valve's chordae, papillary muscles, or leaflets after blunt chest trauma, usually motor vehicle accidents; often diagnosed years later, treated by valve repair or replacement.
Tricuspid valve stenosis
Tricuspid valve stenosis (tricuspid stenosis, ICD-11 BB80) is rare narrowing of the right atrioventricular valve, usually rheumatic, causing right atrial enlargement, venous congestion, and a mean gradient over 5 mmHg in severe cases.
Tricyclic antidepressant
Tricyclic antidepressants (TCAs), including imipramine, amitriptyline, and nortriptyline, are three-ringed drugs that inhibit serotonin and norepinephrine reuptake; discovered by Roland Kuhn in 1957, FDA-approved from 1959, now mainly used for pain and migraine.
Trifarotene
Trifarotene (Aklief) is a fourth-generation topical retinoid, a selective RAR-γ agonist approved by the FDA in October 2019 as a 0.005% once-daily cream for facial and truncal acne vulgaris in patients 9 years and older.
Trifluoperazine
Trifluoperazine is a typical antipsychotic of the piperazine phenothiazine class, first launched as Stelazine by Smith Kline & French in 1958, used mainly for schizophrenia and psychoses and at low doses for anxiety and nausea.
Trifluperidol
Trifluperidol (R-2498, Triperidol) is a butyrophenone antipsychotic and dopamine antagonist similar to haloperidol, synthesized 1959 by Janssen, used for psychoses including schizophrenia and mania; not FDA-approved, mainly available in India.
Triflupromazine
Triflupromazine (Vesprin, Siquil, fluopromazine) is a phenothiazine dopamine D1/D2 antagonist antipsychotic and antiemetic, FDA-approved 1957, discontinued for humans but still a veterinary tranquilizer for dogs, cats, and horses.
Triflusal
Triflusal, marketed as Disgren, is an oral antiplatelet drug related to the salicylates, used to prevent recurrent stroke and myocardial infarction in Europe and South Korea.
Trigeminal nerve
Trigeminal nerve (CN V), the largest cranial nerve, a mixed sensory and motor nerve with ophthalmic (V1), maxillary (V2), and mandibular (V3) branches; V3 alone carries motor fibers to the muscles of mastication; best-known disorder is trigeminal neuralgia.
Trigeminal nerve stimulation
Trigeminal nerve stimulation (TNS) is a neuromodulation treatment that delivers electrical pulses to forehead branches of the trigeminal nerve to treat epilepsy, migraine, depression, and ADHD.
Trigeminal neuralgia
Trigeminal neuralgia: sudden severe electric-shock-like unilateral facial pain from trigeminal nerve compression, usually by the superior cerebellar artery; treated first with carbamazepine, then microvascular decompression, radiosurgery, or rhizotomy.
Trigeminal trophic syndrome
Trigeminal trophic syndrome (TTS), or trigeminal neurotrophic ulceration, is a rare self-induced facial ulceration, typically of the nasal ala, after trigeminal nerve injury from neuralgia treatment, stroke, or herpes zoster.
Trigger finger
Trigger finger (stenosing tenosynovitis, doigt à ressort): a finger or thumb that catches or locks from flexor tendon entrapment at the A1 pulley; first described by Notta in 1850, treated with steroid injection or surgical release.
Trigger point injection
Trigger point injection is a pain medicine procedure in which a needle, usually with local anesthetic, is inserted into a muscle trigger point to relieve pain.
Triglyceride deposit cardiomyovasculopathy
Triglyceride deposit cardiomyovasculopathy (TGCV, 中性脂肪蓄積心筋血管症) is a rare Japanese-described disorder of impaired triglyceride lipolysis causing heart failure, diffuse coronary narrowing, and arrhythmia; diagnosed by BMIPP washout under 10% and treated investigationally with tricaprin (CNT-01).
Trigonitis
Trigonitis: inflammation or benign squamous metaplasia (pseudomembranous trigonitis) of the bladder trigone, affecting up to 40% of adult women, estrogen-linked, diagnosed by cystoscopy, causing UTI-like symptoms with negative cultures.
Triheptanoin
Triheptanoin, sold as Dojolvi and developed by Ultragenyx as UX007, is a synthetic odd-chain triglyceride approved in 2020 to supply calories and fatty acids in long-chain fatty acid oxidation disorders.
Trihexyphenidyl
Trihexyphenidyl (Artane) is a synthetic antimuscarinic anticholinergic drug marketed in 1949 for Parkinson's disease, used for parkinsonism, drug-induced extrapyramidal symptoms, and off-label dystonia, with euphoric effects and misuse potential.
Triiodothyronine
Triiodothyronine (T3, liothyronine as drug), the biologically most active thyroid hormone, discovered 1952 by Gross and Pitt-Rivers, mainly generated from T4 by deiodinases, and used in hypothyroidism treatment.
Trikatu curna (trikatu cirma)
Trikatu curna (Trikatu Cūrṇa), also called trikatu churna, is an Ayurvedic powder of equal parts long pepper, black pepper, and ginger, used for digestion and studied as a piperine-based bioavailability enhancer.
Trilaciclib
Trilaciclib (Cosela) is a CDK4/6 inhibitor infused before chemotherapy to protect bone marrow in extensive-stage small-cell lung cancer; FDA approved February 2021, first myelopreservation drug.
TRILOGY ACS trial
TRILOGY ACS (Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes), NCT00699998: phase 3 trial of 9,326 medically managed UA/NSTEMI patients in which prasugrel did not significantly reduce cardiovascular death, MI, or stroke versus clopidogrel, with similar severe bleeding.
TRIM32-related limb-girdle muscular dystrophy R8
TRIM32-related limb-girdle muscular dystrophy R8 (LGMD R8, formerly LGMD2H, sarcotubular myopathy) is a rare autosomal recessive dystrophy from biallelic TRIM32 mutations, mostly NHL-domain, first seen in Hutterites, with proximal weakness from the second or third decade.
Trimebutine
Trimebutine (trimebutine maleate; brands Modulon, Debridat) is a non-FDA-approved spasmolytic for IBS and postoperative paralytic ileus, acting via opioid receptors, peptide release, and calcium channels; ATC A03AA05, up to 600 mg/day.