25,729 articles
Trimegestone
Trimegestone (RU-27987, 21-hydroxypromegestone) is a synthetic 19-norpregnane progestin used with estradiol in menopausal hormone therapy; potent, progesterone-receptor selective, dosed 0.0625-0.5 mg, also studied in a contraceptive vaginal ring.
Trimetazidine
Trimetazidine (Vastarel) is a piperazine metabolic antianginal drug for stable angina as add-on therapy; it inhibits fatty acid β-oxidation, can cause reversible Parkinsonism, is not FDA approved, and is WADA-prohibited since 2015.
Trimethadione
Trimethadione (Tridione, troxidone) is an oxazolidinedione anticonvulsant approved in the US in 1946 for refractory absence seizures; it blocks thalamic T-type calcium channels and was withdrawn in the mid-1990s.
Trimethaphan
Trimethaphan, marketed as the camsylate salt Arfonad, is a short-acting intravenous ganglionic-blocking antihypertensive used for controlled hypotension in surgery and hypertensive emergencies; a monograph reports its withdrawal from the market in 1996.
Trimethobenzamide
Trimethobenzamide, sold in the United States under the brand name Tigan, is a prescription antiemetic approved in 1974 that treats postoperative nausea and vomiting and nausea from gastroenteritis in adults.
Trimethoprim
Trimethoprim (TMP) is an antibiotic that reversibly inhibits bacterial dihydrofolate reductase; developed by Hitchings and Elion, it is used for urinary tract infections and as co-trimoxazole with sulfamethoxazole.
Trimethoprim/sulfamethoxazole
Trimethoprim/sulfamethoxazole, abbreviated TMP-SMX and sold as Bactrim, is a fixed-dose combination antibiotic introduced in 1968 that blocks bacterial folate synthesis and is the treatment of choice for Pneumocystis pneumonia.
Trimetrexate
Trimetrexate (Neutrexin, trimetrexate glucuronate) is a lipophilic non-classical folate antagonist and DHFR inhibitor used with leucovorin as alternative therapy for Pneumocystis pneumonia and tested as an anticancer agent.
Trimipramine
Trimipramine (Surmontil) is a sedating tricyclic antidepressant for depression, atypical in that its effect is not explained by monoamine reuptake inhibition; dosed 50-300 mg/day orally.
Trimodal therapy (bladder cancer)
Trimodal therapy (TMT) is a bladder-sparing treatment for muscle-invasive bladder cancer combining maximal transurethral resection, radiosensitizing chemotherapy, and radiation, the main alternative to radical cystectomy.
Triose phosphate-isomerase deficiency
Triosephosphate isomerase deficiency (TPI deficiency, TPID) is an ultra-rare autosomal recessive glycolytic enzymopathy caused by TPI1 mutations, mostly E105D, causing hemolytic anemia, progressive neuromuscular degeneration, and childhood death.
Trioxsalen
Trioxsalen (trioxysalen, trimethylpsoralen, TMP, Trisoralen) is a synthetic psoralen (C14H12O3, CAS 3902-71-4) used with UVA in PUVA photochemotherapy, mainly for vitiligo and in Scandinavian bath PUVA for psoriasis; US oral product discontinued in 2002.
Trip killer
Trip killers are drugs, usually benzodiazepines or antipsychotics like alprazolam or quetiapine, taken to blunt or end a bad psychedelic trip; Reddit studies show benzos dominate recommendations, though they calm anxiety without blocking 5-HT2A effects.
Trip sitter
Trip sitter: a sober person present or remotely available during a psychedelic experience to reduce harm and provide reassurance; also called peer support; related to clinical session facilitators, whose effects reached 13.6% of outcome variance in patient trials.
Triparanol
Triparanol (MER/29, metasqualene), a withdrawn Merrell hypolipidemic drug approved by FDA in 1960; first cholesterol-synthesis inhibitor, blocking desmosterol-to-cholesterol conversion, withdrawn 1962 for cataracts and falsified data.
Tripelennamine
Tripelennamine (Pyribenzamine) is a first-generation ethylenediamine H1-antihistamine approved by the FDA in 1948 for itching, hay fever, rhinitis, asthma, and urticaria; systemic forms are discontinued, with a 1% topical cream marketed since 2025.
Triphala curna
Triphala curna (त्रिफला चूर्ण), Ayurvedic Formulary of India entry 7:15, is an equal-parts powder of haritaki, bibhitaka, and amalaki fruit pericarps, used as a laxative and tonic with cardiometabolic trial evidence.
Triphala ghrta
Triphala Ghrita (Triphalā Ghṛta), an official Ayurvedic medicated ghee of amla, haritaki, bibhitaki plus 17 herbs in cow ghee and milk; dose 12 g daily; classical uses include cataract and jaundice; clinical evidence limited.
Triphala guggulu
Triphala Guggulu (triphala guggul), an official Ayurvedic vati of purified Commiphora wightii resin with Triphala fruits and Pippali, used for inflammatory conditions, piles, and fistula; clinical evidence limited and mixed.
Triphaladi taila
Triphaladi taila (Triphalādi taila), a classical Ayurvedic medicated sesame oil cooked with Triphala fruits and about 30 other herbs, used externally as Abhyanga; AFI000065; studied in obesity, dandruff, and hair loss.
Triphalangeal thumb
Triphalangeal thumb (TPT), a congenital anomaly with three phalanges in the thumb, first described 1559; prevalence about 1 in 25,000; autosomal dominant 7q36/ZRS-SHH forms, Holt-Oram association, surgical excision or reduction osteotomy.
Triple A syndrome
Triple A syndrome (Allgrove syndrome, 3A syndrome), an autosomal recessive disorder from AAAS gene mutations on 12q13 encoding the nucleoporin ALADIN, combining achalasia, ACTH-resistant adrenal insufficiency, and alacrima, often with progressive neurological and autonomic dysfunction.
Triple antithrombotic therapy
Triple antithrombotic therapy, or triple therapy, combines an oral anticoagulant with aspirin and a P2Y12 inhibitor like clopidogrel after coronary stenting, most often for atrial fibrillation.
Triple IN trial
Triple IN (NCT01297959) was a Phase 3 randomized double-blind trial of topical E-101 Solution, a glucose oxidase and porcine myeloperoxidase antiseptic, versus saline to prevent incisional surgical site infections after elective colorectal surgery; 503 participants, completed 2015, results posted 2021.
Triple test
The triple test is a second-trimester maternal blood screen measuring AFP, hCG, and estriol to estimate the risk of Down syndrome and neural tube defects.
Triple-blind study
A triple-blind study is a randomized clinical trial in which participants, researchers, and a third party such as data analysts are all unaware of treatment assignment.
Triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a breast cancer whose cells lack estrogen receptors, progesterone receptors, and HER2 protein, leaving chemotherapy and newer drugs as main treatments.
Triplet pregnancy
Triplet pregnancy, a pregnancy with three fetuses, natural or assisted conception; chorionicity drives risk; high prematurity risk; managed by specialist teams; US triplet births fell 62% from 1998 to 2023.
Triplet therapy
Triplet therapy is a cancer treatment using three drugs together, shown to extend survival in metastatic colorectal and pancreatic cancer at the cost of higher toxicity.
Triploidy syndrome
Triploidy syndrome (69,XXX/XXY/XYY) is a usually prenatally lethal chromosomal condition with 69 chromosomes from an extra haploid set; diandric forms cause partial molar pregnancy, digynic forms do not.