72,234 articles
MRE11
MRE11 (MRE11A, HNGS1) is a human 11q21 gene encoding a 3'→5' exonuclease/endonuclease that, with RAD50 and NBS1, forms the MRN complex sensing and repairing DNA double-strand breaks; mutations cause ataxia-telangiectasia-like disorder.
MRGAMADASAVA
Mṛgamadāsava (Mrigamadasava) is a classical Ayurvedic asava, a fermented liquid medicine in the Ayurvedic Formulary of India, made from spices, deer musk, and wine, dosed at 5 to 10 drops.
Mrganga Rasa
Mrganga Rasa (Mṛgāṅkarasa, मृगाङ्करस) is a classical Ayurvedic herbo-mineral Rasa Shastra formulation, mainly indicated for Rajayakshma (tuberculosis); several distinct recipes exist, including a mercury-free kupipakva version with Navasara, Saindhava, Vanga, and Gandhaka.
Mrganka Rasa
Mrganka Rasa (Mṛgāṅka Rasa, Mrigankarasa) is a family of classical Ayurvedic herbo-mineral Rasa Shastra formulations, mostly mercury- and gold-based, used for Rajayakshma (tuberculosis), fevers, and debilitation; variants include Raja Mriganka Rasa, Mahamriganka Rasa, Navaratna Raja Mriganka Rasa, and a mercury-free Kupipakwa recipe.
MRGPRX2
MRGPRX2 (MAS-related GPR family member X2, MRGX2) is a human mast cell GPCR mediating IgE-independent pseudo-allergic degranulation, activated by cationic peptides and basic drugs such as neuromuscular blockers, opioids, and fluoroquinolones.
MRI texture analysis
MRI texture analysis is a quantitative image-analysis method that converts spatial gray-level patterns in MRI scans into numerical features used for tissue characterization, tumor grading, and prognosis.
MRI-ultrasound fusion biopsy
MRI-ultrasound fusion biopsy, also known as ultrasound fusion biopsy, is a prostate biopsy technique that co-registers a pre-biopsy MRI scan onto real-time ultrasound, letting urologists target MRI-visible lesions directly.
MRIA study
MRIA (NCT05746819), An MRI Ancillary Study of a Malaria Fever RCT, is a completed observational study led by Gretchen Birbeck using brain MRI at 1 and 12 months post recovery to test neuroprotection from aggressive antipyretics in pediatric CNS malaria, enrolling 181 children in Malawi and Zambia.
Mriganka Sur
Mriganka Sur is an Indian-born American neuroscientist at MIT, known for experiments that rewired visual input into the auditory cortex and for work on autism and Rett syndrome.
MRIMLD study
MRIMLD (NCT07155135) is a completed retrospective single-center study by Ryka Tashakkor of Socal Heart evaluating 1.5 Tesla MRI safety in 16 patients with non-MRI-conditional, mixed-manufacturer cardiac implantable electronic devices, reporting 23 scans with no adverse events or device parameter changes.
Mrinal M. Gounder
Mrinal M. Gounder is an American medical oncologist at Memorial Sloan Kettering Cancer Center specializing in sarcomas and desmoid tumors, and led the nirogacestat trials.
MRL/MpJ
MRL/MpJ (Murphy Roths Large) is an inbred laboratory mouse strain from The Jackson Laboratory, famous for scar-free regeneration of 2-mm ear punch wounds via a blastema, while healing skin wounds with scar; parent of the lupus-model MRL/MpJ-Faslpr/J strain.
Mrmakantamani Pisti
Mrmakantamani pisti (Trinakantamani pishti, kaharuba pisti) is an Ayurvedic mineral formulation from fossil resin, adopted from Unani medicine in the 19th century; dose 250-500 mg for bleeding disorders such as menorrhagia and Raktapitta.
mRNA 3'-end processing
mRNA 3'-end processing (cleavage and polyadenylation) generates eukaryotic mRNA 3' ends: CPSF73 cleaves pre-mRNA downstream of AAUAAA, poly(A) polymerase adds a ~250-residue tail; histone mRNAs are the exception.
mRNA decapping protein 2, Box A domain
Box A domain of mRNA decapping protein 2 (Dcp2; InterPro IPR007722, Pfam PF05026, SMART SM001125), an N-terminal regulatory domain specific to Dcp2 that aids cap recognition, Dcp1 binding, and catalytic fidelity in mRNA decapping.
mRNA decay factor PAT1 domain
mRNA decay factor PAT1 domain (InterPro IPR019167, Pfam PF09770), a conserved domain in Pat1 scaffold proteins with N-terminal, middle, and ARM-fold PatC regions that bind Dhh1, Lsm1-7, and Dcp2 to activate 5'-3' mRNA decapping.
MRNA display
MRNA display (in vitro virus display) is a cell-free directed-evolution method covalently linking puromycin-captured proteins to their encoding mRNA, enabling 10^12–10^15-variant libraries for macrocyclic peptide drug discovery.
mRNA Editing
mRNA editing, also called RNA editing, is the co- or post-transcriptional alteration of messenger RNA sequence beyond the genome-encoded sequence, via base conversion (A-to-I by ADAR, C-to-U by APOBEC1) or insertion/deletion, altering protein coding and enabling reversible therapeutics.
mRNA interferase PemK-like
mRNA interferase PemK-like (InterPro IPR003477) is a bacterial endoribonuclease toxin family of type II toxin-antitoxin systems, including PemK, Kid, MazF, ChpA, and ChpB, that cleaves single-stranded mRNA to block protein synthesis and is neutralized by PemI antitoxins.
mRNA lipid nanoparticle
An mRNA lipid nanoparticle (mRNA-LNP) is a drug-delivery particle that carries messenger RNA into cells, the delivery system behind the Pfizer/BioNTech and Moderna COVID-19 vaccines.
mRNA lipid nanoparticle delivery
mRNA lipid nanoparticle (mRNA-LNP) delivery encapsulates messenger RNA in lipid nanoparticles so it survives in blood, enters cells, and is translated into protein, the platform behind the approved COVID-19 vaccines.
mRNA nuclear export
mRNA nuclear export is the transport of mature messenger RNA from the nucleus to the cytoplasm through nuclear pore complexes, mainly via the NXF1–NXT1 receptor.
mRNA Polyadenylation
mRNA polyadenylation is the addition of a poly(A) tail to a messenger RNA's 3′ end after cleavage, stabilizing the mRNA, stimulating translation, and occurring in nearly all eukaryotic mRNAs.
mRNA Splicing
mRNA splicing: intron removal from pre-mRNA and exon ligation by the spliceosome (five snRNAs, about 150 human proteins). Discovered 1977; alternative splicing lets over 90% of human intron-containing genes yield multiple proteins; targeted by ASO and exon-editing drugs.
mRNA transfection
mRNA transfection is the delivery of synthetic messenger RNA into cultured cells so their ribosomes translate it into protein, giving fast, tunable, transient expression without genomic integration.
MRNA vaccine
mRNA vaccine: synthetic messenger RNA in lipid nanoparticles (Comirnaty, Spikevax) instructing host cells to make antigen. Nucleoside-modified RNA (pseudouridine) avoids innate immune sensing; 95%/94.1% COVID-19 trial efficacy.
Mrtasanjivani Gutika
Mrtasanjivani Gutika (Mṛtasañjīvanī guṭīkā) is a classical Ayurvedic pill formulation from The Ayurvedic Formulary of India, AFI Part 1 chapter 12, dose 1 g, containing calcined horns, gall stone, and aromatic herbs.
MRTFA
MRTFA, also known as MKL1 or MAL, is a transcriptional coactivator that links the actin cytoskeleton to gene expression, fused to RBM15 in some pediatric leukemia.
Mrtyunjaya Rasa
Mrtyunjaya Rasa (Mṛtyuñjaya rasa, मृत्युञ्जय रस) is a Kharaliya herbo-mineral Ayurvedic antipyretic formulation of purified cinnabar, mercury, sulphur, borax, aconite, and Piper fruits, dosed 125 mg per AFI; distinct from Mahamrutyunjaya rasa.
MS-R trial
MS-R (Right Ventricular Apical Versus True Mid-septal Pacing, NCT02412176) is a randomized pacemaker trial comparing apical with CT-verified true mid-septal lead placement, using LV volume, dyssynchrony, and extracellular matrix endpoints.