72,234 articles
MTX-13 (DAY301)
MTX-13, also called DAY301 or CB-002, is a PTK7-targeting antibody-drug conjugate (Ab13 plus T1000 linker carrying eight exatecan molecules) developed by Multitude Therapeutics and licensed to Day One Biopharmaceuticals in 2024; it is in Phase 1 testing for solid tumors.
Mu opioid receptor
The mu opioid receptor, encoded by the OPRM1 gene, is a G protein-coupled receptor that mediates both the pain relief and the adverse effects of opioids.
Mu-ming Poo
Mu-ming Poo (蒲慕明), born 1948 in Nanjing, is a neuroscientist known for discovering spike-timing-dependent plasticity and for building the Institute of Neuroscience of the Chinese Academy of Sciences in Shanghai.
MUC1
MUC1 (mucin 1, CD227, CA15-3/CA27.29 antigen) is a transmembrane epithelial mucin, overexpressed and hypoglycosylated in many cancers, used as a serum biomarker and targeted-therapy target.
MUC16
MUC16 (mucin 16, CA125 antigen) is a giant chromosome 19 transmembrane mucin whose shed ectodomain carries the CA125 ovarian cancer biomarker; used for monitoring, not screening, and targeted by antibody and CAR-T therapies.
MUC4
MUC4 (mucin 4, cell surface associated) is a heterodimeric transmembrane mucin glycoprotein with 16-residue tandem repeats, NIDO/AMOP/vWD and three EGF-like domains, protecting epithelia and aberrantly expressed in lung, pancreatic, and gallbladder cancers.
MUC5B
MUC5B (mucin 5B) is a large gel-forming, oligomeric airway mucin that polymerizes via VWF-like domains and calcium-mediated cross-links; its promoter variant rs35705950 is the dominant genetic risk factor for idiopathic pulmonary fibrosis.
MUC6
MUC6 (mucin 6, oligomeric mucus/gel-forming; HGNC:7517, Gene ID 4588) is a human gene at 11p15.5 encoding Mucin-6, a secreted gel-forming gastric mucin in the MUC2/MUC5AC/MUC5B cluster, polymorphic in tandem repeats and altered in several cancers.
Mucilage
Mucilage: gel-like plant polysaccharide secreted by seed coats, pericarps, and roots; swells into a hydrogel on hydration. Found in over 80 angiosperm families; aids dispersal, germination, and stress protection, and is used in films, coatings, and drug delivery.
Mucin
Mucins are heavily O-glycosylated glycoproteins (over 50% glycan by mass) forming mucus and the glycocalyx; types include gel-forming MUC2, soluble, and transmembrane mucins protecting epithelia.
Mucin-like domain
Mucin-like domain (PTS domain, O-glycodomain): a proline, serine, threonine-rich protein region, often tandem repeats, densely modified with O-GalNAc glycans by GALNT enzymes in the Golgi, giving mucins their extended bottle-brush shape.
Mucinous adenocarcinoma of ovary
Mucinous adenocarcinoma of ovary (ovarian mucinous adenocarcinoma, MOC), a rare 3–5% subtype of epithelial ovarian cancer; unilateral mucin-producing tumor, good early-stage prognosis, poor advanced-stage survival, expansile versus infiltrative WHO subtypes.
Mucinous cystadenocarcinoma of the pancreas
Mucinous cystadenocarcinoma of the pancreas (MCAC), also called pancreatic mucinous cystic neoplasm with associated invasive carcinoma, is the malignant grade of mucinous cystic neoplasm, arising almost exclusively in middle-aged women in the pancreatic body or tail, with about 60% five-year survival after resection.
Muckle-Wells syndrome
Muckle-Wells syndrome (MWS), an intermediate cryopyrinopathy within CAPS, is an autosomal dominant NLRP3-related autoinflammatory disease causing urticarial rash, recurrent fever, sensorineural hearing loss, and AA amyloidosis, treatable with IL-1 inhibitors.
Mucocele of appendix
Mucocele of appendix (appendiceal mucocele): mucin-filled cystic dilatation of the appendix, a descriptive term covering retention cysts through LAMN, HAMN, and mucinous adenocarcinoma; rupture risks pseudomyxoma peritonei; treated by appendectomy guided by pathology.
Mucociliary Clearance
Mucociliary clearance, also called mucociliary transport, is the lung's primary innate defense: cilia beating in metachronal waves propel a mucus layer trapping inhaled particles and pathogens out of the airways.
Mucocutaneous leishmaniasis
Mucocutaneous leishmaniasis (espundia, mucosal leishmaniasis), a Leishmania sandfly-borne disease destroying nose, mouth, and throat mucosa; mainly L. braziliensis in Bolivia, Brazil, Ethiopia, Peru; treated with pentavalent antimonials.
Mucocutaneous venous malformations
Mucocutaneous venous malformations, formally VMCM, are a rare hereditary vascular malformation causing small venous lesions of the skin and mucosa, inherited in an autosomal dominant pattern.
Mucolipidosis type II
Mucolipidosis type II, or I-cell disease (MLII alpha/beta), a severe autosomal recessive lysosomal storage disorder from GNPTAB mutations causing mannose-6-phosphate tagging failure, presenting at birth with dysostosis multiplex, cardiac and respiratory disease, and death in early childhood.
Mucolipidosis type III
Mucolipidosis type III (pseudo-Hurler polydystrophy), MLIII alpha/beta (GNPTAB) or gamma (GNPTG), is a rare autosomal recessive lysosomal storage disorder from partial GlcNAc-1-phosphotransferase deficiency, causing progressive joint stiffness, short stature, and dysostosis multiplex with median survival of 62 years.
Mucolipidosis type IV
Mucolipidosis type IV (MLIV, OMIM 252650) is an ultra-rare autosomal recessive lysosomal storage disorder caused by MCOLN1 mutations, marked by psychomotor delay, progressive vision loss, achlorhydria, and a 2026 FDA-authorized gene therapy trial.
Mucolipin
Mucolipin (TRPML/MCOLN), a TRP ion channel subfamily of three endolysosomal Ca2+-permeable cation channels (TRPML1-3); TRPML1 mutations cause mucolipidosis type IV, TRPML2 is immune-cell specific.
Mucopenetrating nanoparticles
Mucopenetrating nanoparticles (MPPs), also called mucus-penetrating particles, are drug carriers whose dense PEG coating makes them muco-inert, allowing them to diffuse through mucus instead of being trapped by it.
Mucopolysaccharidosis
Mucopolysaccharidosis (MPS), also called mucopolysaccharidoses, is a group of rare inherited lysosomal storage diseases in which enzyme deficiency causes glycosaminoglycan buildup; types include Hurler, Hunter, Sanfilippo, and Morquio syndromes, treated with ERT, HSCT, and gene therapy.
Mucopolysaccharidosis type 1
Mucopolysaccharidosis type 1 (MPS I, Hurler syndrome, alpha-L-iduronidase deficiency) is a rare autosomal recessive lysosomal storage disorder causing dermatan and heparan sulfate accumulation, treated with HSCT and laronidase enzyme replacement therapy.
Mucopolysaccharidosis type 10
Mucopolysaccharidosis type 10 (MPS10, MPS type X, ARSK deficiency) is an autosomal recessive lysosomal storage disorder from biallelic ARSK variants on 5q15, causing childhood short-trunk short stature with skeletal, cardiac, and ophthalmologic findings but normal cognition.
Mucopolysaccharidosis type 6
Mucopolysaccharidosis type 6 (MPS VI, Maroteaux-Lamy syndrome) is a rare autosomal recessive lysosomal storage disease caused by arylsulfatase B (ARSB) deficiency, treated with galsulfase enzyme replacement therapy since 2005.
Mucopolysaccharidosis type 7
Mucopolysaccharidosis type 7 (MPS VII, Sly syndrome, beta-glucuronidase deficiency) is an ultra-rare autosomal recessive lysosomal storage disease caused by GUSB mutations, treated with vestronidase alfa enzyme replacement therapy.
Mucopurulent chronic bronchitis
Mucopurulent chronic bronchitis, also called chronic suppurative or purulent bronchitis, is chronic bronchitis with thick purulent sputum; ICD-11 CA20.11, ICD-10-CM J41.1, ICD-9 491.1, SNOMED CT 74417001.
Mucopurulent conjunctivitis
Mucopurulent conjunctivitis (ICD-11 9A60.3, ICD-10 H10.0), bacterial conjunctival infection with mucus-and-pus discharge and matted eyelids; usually self-limited, antibiotics modestly speed cure.