72,234 articles
Cetacean stranding
Cetacean stranding: live or dead whales, dolphins, and porpoises beached or found dead in water; single or mass events caused by disease, biotoxins, sonar, vessel strikes, entanglement, and navigation errors.
Cetacean surfacing behaviour
Cetacean surfacing behaviour covers how whales and dolphins surface to breathe, exchange air through the blowhole, and rest between dives, shaping dive-breath trade-offs, noise responses, and survey availability bias.
Cetagliptin phosphate
Cetagliptin phosphate is a DPP-4 inhibitor for type 2 diabetes developed by CGeneTech in Suzhou, China, approved in December 2024 as a Class 1 innovative drug.
Cethromycin
Cethromycin (ABT-773, Restanza) is a second-generation ketolide antibiotic for community-acquired pneumonia; binds 23S rRNA at two sites, overcomes macrolide resistance, noninferior to clarithromycin, FDA approval denied in 2009.
Cetirizine
Cetirizine (Zyrtec, Reactine) is a second-generation H1 antihistamine, the active metabolite of hydroxyzine, used for allergic rhinitis and chronic urticaria; US prescription 1995, OTC 2007, half-life about 10.5 hours, renally excreted.
CETP
CETP (cholesteryl ester transfer protein), also called lipid transfer protein I, is a 476-amino-acid 74 kDa plasma glycoprotein exchanging cholesteryl esters and triglycerides between HDL and LDL/VLDL; its inhibitors raised HDL but mostly failed cardiovascular outcome trials except anacetrapib.
Cetrelimab
Cetrelimab (JNJ-63723283) is an investigational Janssen human IgG4 anti-PD-1 monoclonal antibody, studied intravenously and subcutaneously in LUC1001 and in SunRISe bladder cancer and erdafitinib combination trials.
Cetrorelix
Cetrorelix is a synthetic peptide antagonist of the GnRH receptor, marketed as Cetrotide, used to prevent premature ovulation during ovarian stimulation for in vitro fertilization; it was first approved in the European Union in 1999.
Cettia
Cettia (Bonaparte, 1834) is a genus of cettiid bush warblers, type species Cetti's Warbler Cettia cetti. Molecular phylogenies showed the genus non-monophyletic, with species moved to Horornis and Urosphena.
Cetuximab
Cetuximab (Erbitux), a chimeric human-murine IgG1 anti-EGFR monoclonal antibody from murine mAb 225, FDA-approved February 2004 for KRAS wild-type metastatic colorectal cancer and head and neck squamous cell carcinoma; resistance driven by RAS mutations.
Cetuximab and encorafenib regimen
The cetuximab and encorafenib regimen pairs the EGFR antibody cetuximab with the oral BRAF V600E inhibitor encorafenib to treat BRAF V600E-mutant metastatic colorectal cancer, first FDA-approved in 2020.
Cevimeline
Cevimeline (Evoxac) is an oral muscarinic M1/M3 agonist approved by the FDA in 2000 for dry mouth in Sjögren's syndrome, dosed 30 mg three times daily, with sweating and nausea as main side effects.
Cezmi A. Akdiş
Cezmi A. Akdis is a Turkish physician-scientist in immunology and allergy who directs the Swiss Institute of Allergy and Asthma Research in Davos and is a University of Zurich professor.
CF-O-E-PWV study
CF-O-E-PWV (NCT06836622) is a Brazilian cross-sectional study comparing carotid-femoral, Mobil-O-Graph oscillometric, and formula-estimated pulse wave velocity in 251 hypertensive adults, finding weak concordance (0.36 and 0.46) and non-interchangeability with the reference method.
CFAN study
CFAN study: the Chinese Familial Alzheimer's Disease Network, a nationwide longitudinal FAD cohort founded in 2002 by Jianping Jia at Xuanwu Hospital, Capital Medical University; 69 centers in 26 provinces, NCT03657732, 404 pedigrees with 1,330 patients, targeting 40,000 subjects.
CFG920 (LAE001)
CFG920 (LAE001, lapiteronel) is an oral non-steroidal dual CYP17A1/CYP11B2 inhibitor for prostate cancer, discovered by Novartis and licensed worldwide to Laekna in 2017.
CFHR1
CFHR1 (complement factor H-related 1, HGNC:4888) encodes FHR-1, a five-SCR serum complement regulator on chromosome 1q31.3. Its common deletion with CFHR3 protects against AMD but raises aHUS risk; CFHR1*A raises AMD risk.
CFL1
CFL1 (cofilin 1, alias CFL) is a human gene at 11q13.1 encoding cofilin-1 (UniProt P23528, 166 aa), a pH-dependent actin-severing protein regulated by Ser3 phosphorylation, essential in mice and implicated in cancer metastasis and neurodegeneration.
CFPAC-1
CFPAC-1 (CF PAC-1, CVCL_1119, ATCC CRL-1918) is a human pancreatic ductal adenocarcinoma cell line from a 26-year-old male with cystic fibrosis, homozygous for CFTR ΔF508, KRAS G12V, TP53 C242R, SMAD4-deleted, gemcitabine-sensitive.
CG-1 DNA-binding domain
CG-1 DNA-binding domain: ~130-aa eukaryotic DNA-binding module in CAMTA transcription factors, named after a 1994 parsley cDNA, recognizing CGCG-core motifs; no 3D structure known.
CGGC domain
CGGC domain (CDD cl02356) is a putative conserved protein domain containing a highly conserved central CGGC sequence and many conserved cysteines and histidines, suggestive of a zinc binding function, found across cellular organisms.
CGM&VLBWI trial
CGM&VLBWI (NCT02583776) was a randomized trial at University Hospital Padova testing unblinded Dexcom G4 continuous glucose monitoring with a PID algorithm in 50 very low birth weight preterm infants, raising time in euglycemia from 68% to 84%.
CH-like domain in sperm protein
CH-like domain in sperm protein (Spef domain, InterPro IPR010441, Pfam PF06294): a calponin-homology-like domain in sperm flagellar proteins Spef1/Spef2, not actin-binding, linked to immotile sperm when truncated.
CHA2DS2–VASc score
CHA2DS2-VASc score, also CHA2DS2-VA since 2024 ESC guidelines, a 0-9 point clinical score estimating stroke and thromboembolism risk in atrial fibrillation to guide oral anticoagulation decisions.
Chad A. Cowan
Chad A. Cowan, also known as Chad Cowan, is a stem cell biologist who derived 17 human embryonic stem cell lines and now leads Century Therapeutics as CSO.
Chad Nusbaum
Chad Nusbaum is a genomics technologist known for large-scale genome sequencing at the Broad Institute, co-author of the 2001 draft human genome, and lead author of the finished chromosome 18 sequence.
Chaenomeles
Chaenomeles (flowering quince, Japanese quince) is an Asian genus of four spiny Rosaceae shrubs, grown for early spring flowers and aromatic fruit used in jams and traditional Chinese medicine.
Chaerephon
Chaerephon (Dobson, 1874), lesser mastiff or free-tailed bats of Molossidae; about 20 species from Africa, Arabia, Asia, Australia, Oceania; often now treated as a subgenus of Mops; includes the little free-tailed bat C. pumilus.
Chaerophyllum
Chaerophyllum is a genus of annual, biennial, and perennial herbs in the carrot family, commonly known as chervils, named by Linnaeus in 1753 with about 70 accepted species.
Chaetetes
Chaetetes (Eichwald, 1829) is an extinct genus of calcareous, reef-building demosponge with honeycomb calicle skeletons, once classed as a tabulate coral; known from Ordovician to Late Jurassic, status doubtful in GBIF.