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Cox's Orange Pippin
Cox's Orange Pippin, also called Cox Orange, is an English dessert apple cultivar raised about 1825 by Richard Cox at Colnbrook, Buckinghamshire, from Ribston Pippin seed; rich aromatic flavor, pollination group 3, parent of many cultivars.
Coxiella burnetii
Coxiella burnetii, the Q fever bacterium (also Rickettsia burneti, Nine Mile agent), is a Gram-negative obligate intracellular gammaproteobacterium of Legionellales that replicates in lysosome-derived vacuoles of macrophages via a Dot/Icm type IVB secretion system.
Coxopodopatellar syndrome
Coxopodopatellar syndrome, also called small patella syndrome or Scott-Taor syndrome (OMIM 147891), is a rare autosomal dominant TBX4-related skeletal dysplasia with absent or small kneecaps, pelvic and foot anomalies, and sometimes pulmonary arterial hypertension.
Coxsackie A virus
Coxsackie A virus (CA), coxsackievirus group A, human enteroviruses of Picornaviridae first isolated in 1948 at Coxsackie, New York; 23 serotypes causing hand, foot, and mouth disease, herpangina, and hemorrhagic conjunctivitis, with CVA6 now predominant.
Coxsackie carditis
Coxsackie carditis: heart inflammation (myocarditis, pericarditis) caused by coxsackievirus B, chiefly CVB3, the most common cause of infectious myocarditis; injury is viral then autoimmune; treatment supportive.
Coxsackievirus
Coxsackievirus, an Enterovirus genus picornavirus discovered in Coxsackie, New York, in 1947-1948, comprises group A (23 serotypes) and group B (6 serotypes) viruses causing HFMD, herpangina, myocarditis, and meningitis.
Coydog
A coydog, or dog-coyote hybrid, is the hybrid offspring of a coyote and a domestic dog, rare in the wild because the two breeding seasons rarely align.
Coyote
Coyote (Canis latrans), a medium-sized North American canid, also called song dog; historically a western grassland species that expanded 40% in range since 1900 across the continent, hybridizing with wolves and living in cities.
Coywolf
Coywolf, also called eastern coyote (Canis latrans × C. lycaon), a hybrid canid of northeastern North America with 60–84% coyote, 8–25% wolf, and 8–11% dog DNA, larger than western coyotes; naming remains debated.
CP fascia trial
CP fascia trial (NCT06837025), a Finnish pilot RCT comparing Stecco fascial manipulation with traditional stretching in 20 children aged 7-14 with spastic cerebral palsy, GMFCS II-III, one weekly session for 8 weeks; feasibility-focused, results expected 2027.
CPB2
CPB2 (TAFI, carboxypeptidase U), gene on chromosome 13q14.13, encodes a liver-derived plasma carboxypeptidase activated by thrombin-thrombomodulin that removes C-terminal lysines from fibrin, slowing clot lysis; polymorphisms affect thrombosis risk and drug development.
CPC-N
CPC-N (CVCL_1146, RRID:CVCL_1146; synonyms CPC.N, CPCN, CPN) is a human small cell lung carcinoma cell line established in 1987 from a pleural effusion metastasis, distributed by DSMZ as ACC-306, TP53-mutant and microsatellite stable.
CPEB
CPEB (cytoplasmic polyadenylation element binding protein) family: CPEB1–4 in vertebrates, Orb/Orb2 in Drosophila; sequence-specific mRNA binding proteins controlling poly(A) tail length, translation, oocyte maturation, senescence, cancer, and memory.
CpG Islands
CpG islands are CpG-rich, typically unmethylated DNA stretches, several hundred to a few thousand base pairs long, found mostly at gene promoters; promoter hypermethylation silences tumor suppressor genes in cancer.
CpG site
CpG site: a cytosine-guanine dinucleotide in DNA, the main target of vertebrate DNA methylation. Also called CpG dinucleotide. Established by DNMT3A/B, maintained by DNMT1 with UHRF1; CpG islands stay unmethylated; methylated CpGs are mutation hotspots.
CPH domain
CPH domain: conserved protein-protein interaction module in CUL7, PARC/CUL9, and HERC2 E3 ubiquitin ligases that binds the tetramerization domain of p53; five-stranded beta-barrel fold, distinct from pleckstrin's C-terminal PH domain.
Cpi 613
CPI-613 (devimistat) is a lipoate-analog anticancer drug inhibiting mitochondrial PDH and alpha-ketoglutarate dehydrogenase; its phase III trials AVENGER 500 (pancreatic cancer) and ARMADA 2000 (AML) both failed their primary endpoints.
CPI-17
CPI-17 (PPP1R14A), a 17-kDa smooth muscle protein, inhibits myosin phosphatase when phosphorylated at Thr38 by PKC or ROCK, mediating calcium sensitization of contraction.
CPIC trial
CPIC trial (Community Partners in Care, NCT01699789): cluster-randomized Los Angeles trial of 95 programs and 1,246 depressed adults comparing community coalition engagement (CEP) versus technical assistance (RS) for depression care.
CPT1A
CPT1A encodes carnitine palmitoyltransferase 1A, a liver enzyme importing long-chain fatty acids into mitochondria. Its Arctic variant p.Pro479Leu swept to 68–85% frequency in circum-Arctic peoples despite causing hypoketotic hypoglycemia.
Crab
Crab (Brachyura): true crabs, about 7,000 species in 98 families, sister to Anomura false crabs; Jurassic origin about 180 Ma, Cretaceous radiation, freshwater crabs with two independent origins, carcinization, and major fisheries.
Crab anatomy
Crab anatomy covers the structure of true crabs: a broad carapace over the cephalothorax, a reduced abdomen folded underneath, five walking leg pairs, and claws used for feeding and defense.
Crab life cycle
The crab life cycle runs from an egg mass carried on the mother's abdomen through planktonic zoea and megalopa larvae to a juvenile that grows by molting.
Crab louse
Crab louse (Pthirus pubis, pubic louse), a human ectoparasitic insect infesting coarse pubic and body hair, spread mainly by sexual contact, causing itching, treated with permethrin or pyrethrins.
Crab-eating macaque
Crab-eating macaque (Macaca fascicularis), also long-tailed or cynomolgus macaque, a Southeast Asian primate; IUCN Endangered since 2022, the world's most heavily traded primate, widely used in biomedical research.
Crabronidae
Crabronidae (Latreille, 1802), crabronid wasps including sand wasps, cicadakillers, and mud daubers, is a family of solitary predatory apoid wasps with over 9,100 species; bees arise from within it, making it polyphyletic.
Cracidae
Cracidae, the chachalacas, guans, and curassows, is a Neotropical family of 11 genera and about 50 arboreal galliform birds from south Texas to Argentina, frugivorous seed dispersers, with about half the species threatened by hunting and deforestation.
Crack cocaine
Crack cocaine is the smokable free base of cocaine, sold as rocks, named for the crackling sound when heated. Emerged in New York City in 1985, drove the 1980s US crack epidemic and the 100-to-1 federal sentencing disparity, later reduced by the Fair Sentencing Act of 2010.
Crack epidemic in the United States
Crack epidemic in the United States: 1980s surge of smokable crack cocaine, hitting full force in 1985 and reaching 28 states by 1986, driving addiction, violence, the 100:1 sentencing disparity, and lasting harm to young Black males.
Crackles
Crackles: brief, discontinuous adventitious lung sounds heard on auscultation, typical of fibrotic ILD, pneumonia, and heart failure; also called crepitations, with moderate interobserver reliability and automated detection via computerized lung sound analysis.