72,234 articles
Curry-Jones syndrome
Curry-Jones syndrome (corpus callosum agenesis-polysyndactyly syndrome, OMIM 601707) is a rare mosaic disorder caused by SMO c.1234C>T, with craniosynostosis, polysyndactyly, skin, eye, gut anomalies, and medulloblastoma risk.
Curt D. Furberg
Curt D. Furberg, born 1936 in Sweden, is a Swedish-born American clinical-trial researcher and professor emeritus at Wake Forest University, known for questioning calcium channel blockers and leading ALLHAT.
Curt D. Sigmund
Curt D. Sigmund is an American cardiovascular physiologist who studies how the renin-angiotensin system and PPARγ regulate blood pressure, chairing Physiology at the Medical College of Wisconsin.
Curt R. Freed
Curt R. Freed, born 1943, is an American physician and professor emeritus at the University of Colorado known for transplanting fetal dopamine cells into Parkinson's patients' brains.
Curt Stern
Curt Stern (1902–1981) was a German-American geneticist who proved in 1931 that crossing over involves physical exchange of chromosome segments and wrote the leading human genetics textbook.
Curt Wittenberg
Curt Wittenberg is a molecular biologist at Scripps Research in La Jolla, California, known for work on the genes and protein machines that launch the cell division cycle in budding yeast.
Curtis B. Wilson
Curtis B. Wilson (1936–2013) was an American physician-scientist and professor emeritus at The Scripps Research Institute, known for the first comprehensive clinical description of anti-GBM antibody-induced glomerulonephritis.
Curtis C. Harris
Curtis C. Harris is an American cancer researcher who led the National Cancer Institute's Laboratory of Human Carcinogenesis and is known for p53 and microRNA lung cancer research.
Curtis Gates Lloyd
Curtis Gates Lloyd (1859–1926) was an American mycologist and pharmacist from Florence, Kentucky, who funded his fungal research through the family firm Lloyd Brothers and left a herbarium of about 59,000 specimens.
Curtis Huttenhower
Curtis Huttenhower is a computational biologist at Harvard and the Broad Institute known for his work on the human microbiome and the NIH Human Microbiome Project.
Curtis Lester Mendelson
Curtis Lester Mendelson (1913–2002) was an American obstetrician and cardiologist whose 1946 study of aspiration during obstetric anesthesia defined Mendelson's syndrome; he later served as the sole doctor on a Bahamian island.
Curtis P. Van Tassell
Curtis P. Van Tassell is an American research geneticist at the USDA Agricultural Research Service in Beltsville, Maryland, who helped transform dairy cattle breeding through genomic prediction.
Curtis Prout
Curtis Prout (1915–2011) was a Harvard-trained American physician and leading figure in prison medicine who founded the National Commission on Correctional Health Care and wrote Care and Punishment (1988).
Curvularia
Curvularia (Boedijn 1933) is a genus of Pleosporaceae fungi, grass pathogens and rare human pathogens, redefined by molecular phylogeny from the Bipolaris-Cochliobolus complex, and used industrially for steroid biotransformation.
Cuscuta
Cuscuta (dodder), genus of about 200-210 parasitic herbs in Convolvulaceae; obligate stem holoparasites lacking chlorophyll and roots, attaching via haustoria to host xylem and phloem; major agricultural weeds with broad, habitat-dependent host ranges.
Cushing reflex
Cushing reflex (vasopressor response, Cushing reaction): physiological response to acute intracranial pressure elevation, producing Cushing's triad of widened pulse pressure, bradycardia, and irregular respirations; proposed by Harvey Cushing in 1901.
Cushing syndrome due to bilateral macronodular adrenocortical disease
Cushing syndrome due to bilateral macronodular adrenocortical disease (BMAD, also PBMAH), a rare ACTH-independent adrenal Cushing syndrome from bilateral >1 cm benign adrenal macronodules; ARMC5 and KDM1A genes, prevalence under 1 per million.
Cushing syndrome due to ectopic ACTH secretion
Ectopic ACTH syndrome (ectopic Cushing's syndrome): Cushing's syndrome caused by non-pituitary tumors, usually SCLC or bronchial carcinoids, secreting ACTH; diagnosed via IPSS and PET/CT, treated by resection or adrenalectomy.
Cushing's disease
Cushing's disease, also known as Itsenko-Cushing's disease, is a disorder in which a benign ACTH-secreting pituitary tumor drives cortisol overproduction, and the most common cause of endogenous Cushing's syndrome.
Cushing's syndrome
Cushing's syndrome, also called hypercortisolism, results from prolonged excess cortisol, most often from glucocorticoid drugs; endogenous cases are usually ACTH-dependent pituitary Cushing's disease, with diagnosis by urinary, salivary, and dexamethasone suppression tests and elevated mortality.
Custirsen
Custirsen (OGX-011, ISIS 112989, custirsen sodium) is a second-generation antisense oligonucleotide inhibiting clusterin; phase 3 SYNERGY and AFFINITY trials showed no survival benefit in prostate cancer.
Custodial Care
Custodial care: long-term, non-medical help with activities of daily living (bathing, dressing, eating), also called long-term care. Distinct from skilled care; excluded from Medicare coverage, mainly paid privately or by Medicaid in nursing homes.
CUT&RUN
CUT&RUN (Cleavage Under Targets and Release Using Nuclease) is a molecular biology assay that maps where a protein contacts DNA genome-wide, reported by Skene and Henikoff in 2017.
CUT&Tag
CUT&Tag (Cleavage Under Targets and Tagmentation) is an antibody-based sequencing method mapping histone modifications and chromatin proteins, working from as few as 100 cells in one day.
Cutaneous Administration
Cutaneous administration delivers drugs through the skin, spanning topical local action and transdermal systemic delivery via patches. Key facts: stratum corneum barrier, sub-500 Da drug criteria, 1979 scopolamine first patch, enhancement methods.
Cutaneous amoebiasis
Cutaneous amoebiasis (amebiasis cutis), rare skin and soft-tissue infection by Entamoeba histolytica trophozoites, usually secondary to intestinal or hepatic amoebiasis; painful necrotic anogenital ulcers, erythrophagocytosis on histology, metronidazole treatment.
Cutaneous collagenous vasculopathy
Cutaneous collagenous vasculopathy (CCV), a rare idiopathic skin microangiopathy first described in 2000, causing widespread telangiectasias from type IV collagen vessel wall thickening; distinguished from generalized essential telangiectasia by biopsy.
Cutaneous cysts
Cutaneous cysts (skin cysts, ICD-11 EK70) are epithelium-lined sacs in the skin filled with keratin, sebum, or fluid. Main types: epidermoid cyst, milium, pilar (trichilemmal) cyst; mostly benign, rarely malignant.
Cutaneous diphtheria
Cutaneous diphtheria, skin diphtheria caused by toxin-producing Corynebacterium diphtheriae or C. ulcerans, presents as slow-healing ulcers or scaling rash; now the majority form of diphtheria in outbreaks, treated with antibiotics and vaccination.
Cutaneous epithelioid angiomatous nodule
Cutaneous epithelioid angiomatous nodule (CEAN) is a rare benign vascular skin tumor first described by Brenn and Fletcher in 2004, with about 65 reported cases, solid epithelioid endothelial cells, CD31/CD34/ERG positivity, and no recurrences after excision.